Results 131 to 140 of about 8,978 (173)

Targeted proteomics analysis in type 1 diabetes identifies lower agouti-related protein levels in individuals with impaired hypoglycaemia awareness. [PDF]

Sci Rep
Varkevisser RDM, Petrera A, Hauck SM, Mul D, Aanstoot HJ, Paterson A, Wolffenbuttel BHR, van der Klauw MM, Dutch Type 1 Diabetes Biomarker Group.   +8 more
europepmc   +1 more source

Incretin receptor agonism rapidly inhibits AgRP neurons to suppress food intake in mice. [PDF]

J Clin Invest
McMorrow HE, Cohen AB, Lorch CM, Hayes NW, Fleps SW, Frydman JA, Xia JL, Samms RJ, Beutler LR.   +8 more
europepmc   +1 more source

Hunger modulates exploration through suppression of dopamine signaling in the tail of the striatum. [PDF]

Neuron
Kamath T, Lodder B, Bilsel E, Green I, Dalangin R, Raghubardayal M, Wang W, Capelli P, Legister J, Timmins J, Hulshof L, Wallace JB, Tian L, Uchida N, Watabe-Uchida M, Sabatini BL.   +15 more
europepmc   +1 more source

Emerging role of AgRP neurons as integrators of metabolic, sensory and environmental cues in the control of energy homeostasis. [PDF]

Rev Endocr Metab Disord
Faour M, Mesto N, Martin C, Luquet S.
europepmc   +1 more source

AgRP neuronal activity across feeding‐related behaviours [PDF]

European Journal of Neuroscience, 2021
Abstract AgRP neurons trigger one of the most potent orexigenic responses and are both necessary and sufficient for feeding. Recent technical advances for monitoring in vivo neuronal activity have revisited a previously well‐established model of AgRP neurons' feeding regulatory effects.
Sophie M Steculorum
exaly   +4 more sources

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Opioidergic Regulation of AgRP Neurons

Physiology, 2023
Opioids are generally known to promote hedonic consumption. Although much of the existing evidence is primarily based on studies in mesolimbic pathway, endogenous opioids and their receptors are widely expressed in hypothalamic appetite circuits; however, their role in homeostatic feeding remains unclear.
Deniz Atasoy, Nilufer Sayar Atasoy, Yavuz Yavuz, Connor Laule, Chunyang Dong, Hyojin Kim, Iltan Aklan, Lin Tian   +7 more
openaire   +1 more source

mTORC1 signaling in Agrp neurons mediates circadian expression of Agrp and NPY but is dispensable for regulation of feeding behavior

Biochemical and Biophysical Research Communications, 2015
Orexigenic agouti-related protein/neuropeptide Y (Agrp/NPY) neurons and an orexigenic pro-opiomelanocortin (POMC) neurons of the hypothalamus regulate feeding behavior and energy homeostasis. An understanding of the molecular signaling pathways that regulate Agrp/NPY and POMC function could lead to novel treatments for metabolic disorders.
Michael N Hall
exaly   +5 more sources

AgRP neurons encode circadian feeding time

Nature Neuroscience, 2023
Food intake follows a predictable daily pattern and synchronizes metabolic rhythms. Neurons expressing agouti-related protein (AgRP) read out physiological energetic state and elicit feeding, but the regulation of these neurons across daily timescales is poorly understood.
Nilufer Sayar-Atasoy, Iltan Aklan, Yavuz Yavuz, Connor Laule, Hyojin Kim, Jacob Rysted, Muhammed Ikbal Alp, Debbie Davis, Bayram Yilmaz, Deniz Atasoy   +9 more
openaire   +2 more sources

The NPY/AgRP neuron and energy homeostasis

International Journal of Obesity, 2001
Kennedy hypothesized nearly 50 y ago that negative feedback regulation of body fat stores involves hormones that circulate in proportion to adiposity and enter the brain, where they exert inhibitory effects on food intake and energy balance. Recent studies implicate leptin and insulin as 'adiposity signals' to the brain that promote negative energy ...
G J, Morton, M W, Schwartz
openaire   +2 more sources

AgRP signalling negatively regulates bone mass

Journal of Neuroendocrinology, 2021
AbstractThe central nervous system is an active and major regulator of bone structure and remodelling. Specifically, signalling within the hypothalamus has been shown to be critical to ensuring that skeletal functions align with whole body metabolic supply and demand. Here, we identify agouti‐related peptide (AgRP), an orexigenic peptide exclusively co‐
Ronaldo F. Enriquez, Nicola J. Lee, Herbert Herzog   +2 more
openaire   +2 more sources