Results 61 to 70 of about 7,162 (211)

Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab

Annals of Clinical and Translational Neurology, Volume 13, Issue 4, Page 688-699, April 2026.
ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer, Frauke Stascheit, Maximilian Mönch, Paolo Doksani, Carla Dusemund, Meret Herdick, Philipp Mergenthaler, Maike Stein, Amani Suboh, Jutta Schröder‐Braunstein, Guido Wabnitz, Jan D. Lünemann, Sophie Lehnerer, Sarah Hoffmann, Andreas Meisel   +14 more
wiley   +1 more source

Limitations of Complement Activity Assays as Biomarkers for Ravulizumab Therapeutic Monitoring

Annals of Clinical and Translational Neurology, Volume 13, Issue 6, Page 1301-1302, June 2026.
Francesco Saccà, Ryan Pelto
wiley   +1 more source

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

Advanced Science, Volume 13, Issue 24, 27 April 2026.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang   +36 more
wiley   +1 more source

Living with Atypical Hemolytic Uremic Syndrome in the Netherlands: Patient and Family Perspective

Kidney International Reports
Introduction: Atypical hemolytic uremic syndrome (aHUS) poses a significant health challenge due to its rarity and severity within the spectrum of thrombotic microangiopathy. Despite efforts to optimize and personalize health care for patients with aHUS,
Romy N. Bouwmeester, Leonie J. Engel, Wim Altena, Caroline Renette, Clim van Daelen, Evy van Kempen, Renée de Wildt, Nicole C.A.J. van de Kar   +7 more
doaj   +1 more source

Optimization of Phenolic and Flavonoid Extraction From Bee Bread Using Response Surface Methodology and Central Composite Design, and Evaluation of Antimicrobial Activity

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
This study successfully optimized the extraction parameters for Turkish bee bread using Response Surface Methodology (RSM) with a Central Composite Design (CCD). Under optimized conditions (30°C, 40 mL/g ratio, 66.7% ethanol, 20 h), the recovery of total phenolics (26.86 mg GAE/g) and flavonoids was maximized.
Nilay Keyvan, Muhammet Mükerrem Kaya, Melike Sultan Demirağ, Murat Bayezit, Hidayet Tutun, Hatice Ahu Kahraman, Erhan Keyvan   +6 more
wiley   +1 more source

Real-world use of complement inhibitors for haemolytic uraemic syndrome: an analysis of the European Rare Kidney Disease Registry cohortResearch in context

EClinicalMedicine
Summary: Background: Although terminal complement inhibitors transformed the prognosis of atypical haemolytic uraemic syndrome (aHUS) from dismal to favourable, treatment approaches vary due to the intermittent disease nature and high costs ...
Aleksandra Vujović, Anne-Laure Sellier-Leclerc, Maria Cristina Mancuso, Olivia Boyer, Atif Awan, Antonio Gargiulo, Sebastian Loos, Marc Fila, Augustina Jankauskiene, Gema Ariceta, Nele Kanzelmeyer, Enrico Vidal, Maria Van Dyck, Tanja Kersnik Levart, Naděžda Šimánková, Stephane Decramer, Jonas Hofstetter, Marina Vivarelli, Savino Sciascia, Nicole C.A.J. van de Kar, Franz Schaefer, Nicole C.A.J. van de Kar, Marina Vivarelli, Savino Sciascia, David Kavanagh, René Andersen, Mia Faerch, Soren Rittig, Miquel Blasco, Pedro Arango Sancho, Alvaro Madrid, Gema Ariceta, Loreto Gesualdo, Camillo Carrara, Piero Ruggenenti, Kai-Uwe Eckardt, Jan Halbritter, Dominik Müller, Adrian Schreiber, Evelyn Seelow, Yahsou Delmas, Jerome Harambat, Brigitte Llanas, Nathalie Godefroid, Eric Goffin, Johann Morelle, Adrian Catalin Lungu, George Reusz, Péter Sallay, Attila Szabo, Kalman Tory, Jan Ulrich Becker, Kathrin Burgmaier, Volker Burst, Sandra Habbig, Max Liebau, Roman-Ulrich Mueller, Lutz Weber, Mette Damholt, Anne-Lise Kamper, Karl Emil Nelveg-Kristensen, Hanne Nørgaard, Ida Maria Schmidt, Soeren Soerensen, Wladimir Szpirt, Agnieszka Jaskólska, Monika Miklaszewska, Anna Moczulska, Elżbieta Szczęsny-Choruz, Katarzyna Zachwieja, Peter Conlon, Atif Awan, Michael Wiesener, Anja Büscher, Rainer Büscher, Lars Pape, Francesca Becherucci, Paola Romagnani, Ann Raes, Thomas Renson, Evelien Snauwaert, Johan Vande Walle, Jill Vanmassenhove, Mark Eijgelsheim, Casper Franssen, Coen Stegeman, Florian Grahammer, Thomas Henne, Tobias Huber, Christian Krebs, Sebastian Loos, Anne Mühlig, Jun Oh, Ulf Panzer, Raphael Schild, Jessica Kaufeld, Stefanie Haeberle, Franz Schaefer, Tanja Wlodkowski, Juuso Tainio, Elisa Ylinen, Obbo Bredewold, Wieneke Michels, Dorien Peters, Antonius Rabelink, Arghya Ray, Joris Rotmans, Siebe Spijker, Y.K. Onno Teng, Kathleen Claes, Noel Knops, Tanja Kersnik Levart, Anamarija Meglič, Gregor Novljan, Agnieszka Gach, Monika Pawlak-Bratkowska, Małgorzata Stańczyk, Marcin Tkaczyk, Pierre Cochat, Anne-Laure Sellier-Leclerc, Teresa Cavero, Eduardo Guiterrez, Joaquin Martinez, Enrique Morales, Hernando Trujillo, Gianluigi Ardissino, Valentina Capone, Sara Testa, Denis Morin, Martin Konrad, Ilaria Luongo, Gabriele Malgieri, Luigi Annicchiarico Petruzzelli, Wilbert van der Meijden, Jack Wetzels, Mattia Parolin, Enrico Vidal, Thérésa Kwon, Olivia Boyer, Aude Servais, Laurent Mesnard, Alena Parikova, Silvie Rajnochova-Bloudickova, Janka Slatinska, Ondrej Viklicky, Martin Bezdicka, Nadezda Simankova, Dana Thomasova, Jakub Zieg, Francesco Emma, Rocco Baccaro, Giuseppe Grandaliano, Alessandro Naticchia, Francesco Pesce, Margherita Baldassarri, Andrea Guarnieri, Anna Maria Pinto, Alessandra Renieri, Stephane Decramer, Stanislas Faguer, David Ribes, Thomas Simon, Stephanie Tellier, Daniel Gale, Christoph Licht, Michal Malina, Candice Roufosse, Neil Sheerin, Susana Carvajal Arjona, Renée de Wildt, Uwe Korst, Christiane Mockenhaupt, Francisco Monfort, Mireya Vicenta Rios Carratala   +173 more
doaj   +1 more source

Atypical Hemolytic Uremic Syndrome post Kidney Transplantation: Two Case Reports and Review of the Literature

Frontiers in Medicine, 2014
Atypical hemolytic uremic syndrome (aHUS) is a rare disorder characterized by over-activation and dysregulation of the alternative complement pathway. Its estimated prevalence is 1-2 per million. The disease is characterized by thrombotic microangiopathy,
Sami eAlasfar, Nada eAlachkar
doaj   +1 more source

Antimicrobial‐Resistance Genetic Markers Among Multidrug‐Resistant Enterobacteriaceae and Acinetobacter spp. From Vegetable Market Chains in Ethiopia

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Schematic overview of the study workflow explaining isolation of lactose‐fermenting Gram‐negative bacteria from farms and supermarkets, antimicrobial susceptibility testing, detection of resistance genes by PCR, and ERIC‐PCR to evaluate genetic diversity and relatedness among isolates.
Hemen Tesfaye, Adey Feleke Desta, Ahu Reis, Mine Egin, Osman Birol Ozgumus, Neslihan Akarsu, Mujib Abdulkadir, Haile Alemayehu, Tadesse Eguale, Ali Osman Kilic   +9 more
wiley   +1 more source

atypisches hämolytisch urämisches Sydrom (aHUS)

, 2020
ZusammenfassungDas Kapitel 10 beinhaltet eine Zusammenstellung der am Universitätsklinikum Freiburg verwendeten Tumortherapie- und ggf. Studien-Protokolle der Entität Atypisches hämolytisch-urämisches Syndrom (aHUS). Der Kapitelinhalt orientiert sich an aktuellen Leitlinien und Therapieempfehlungen und spiegelt detailliert die Therapieabläufe inkl ...
Monika Engelhardt, Roland Mertelsmann, Justus Duyster   +2 more
openaire   +1 more source

The Eco-Design Directive ErP for AHUs

, 2017
The European ErP-Directive 2009/125/EG (Energy-related-Products-Directive), also called the Eco-Design Directive, defines the minimal requirements for energy-related products.
Cătălin George Popovici
core   +1 more source