Results 111 to 120 of about 2,279,840 (310)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Towards Modeling HIV Long Term Behavior

, 2011
The precise mechanism that causes HIV infection to progress to AIDS is still unknown. This paper presents a mathematical model which is able to predict the entire trajectory of the HIV/AIDS dynamics, then a possible explanation for this progression is ...
Hernandez-Vargas, Esteban A., Mehta, Dhagash, Middleton, Richard H.   +2 more
core   +1 more source

Comparação da coleta das amostras de sangue na triagem pré-natal, utilizando o papel de filtro e punção venosa na técnica de ELISA para detecção de HIV 1+2

DST, 2010
Introdução: apesar de o papel de filtro (PF) ter sido introduzido desde o século passado, (1963) por Guthrie e Susi, nas triagens neonatais, como alternativa para a coleta da amostra do sangue, seus benefícios na aplicação da prática médica laboratorial
Juan Fidel Bencomo Gómez, Marco A.O. Appolinário, Dolores M.F. Abreu, Antonio J.W. Castro, Jordi Martí, Sidney Prates, Cristimar dos Santos   +6 more
doaj  

Toksoplasmosis Serebral Pada Pasien dengan HIV/AIDS: Laporan Kasus

Scripta Score Scientific Medical Journal
Background: Toxoplasma encephalitis (ET) is the most common opportunistic infection that causes encephalitis or focal cerebral lesions in HIV/AIDS sufferers which occurs in approximately 3% to 40% of patients.
Gede Ari Mahendra Mardaningrat, Dwiputra Yogi Pramartha, Ni Komang Darmiastini   +2 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Vulnerability of adolescents to sexually transmitted infections

DST, 2018
Introduction: Adolescents are especially susceptible to sexually transmitted infections, with approximately 1/7 of all new cases of human immunodeficiency virus infection in this group. Objective: To investigate the vulnerability to sexually transmitted
Raisa Evaly Alves de Rezende, Rosane Silvia Davoglio, Caroline Ferreira de Oliveira, Acássio dos Santos Amorim Viana, Artur Alves da Silva, Ananda Ariane Januário do Nascimento, Tárcia Rita Davoglio   +6 more
doaj  

AIDS [PDF]

Eye, 1988
openaire   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Diagnóstico diferencial das manifestações da sífilis e da Aids com líquen plano na boca

DST, 2012
A sífilis segue um curso semiológico em que aparece, desaparece e ressurge com variados sinais e sintomas, exigindo dos examinadores conhecimentos clínicos e laboratoriais que os conduzam ao seu diagnóstico.
Andrea B. Moleri, Camila B. Lobo, Felipe R Santos, Ednaldo José da Silva, Cresus Vinícius D. Gouvêa, Luiz Carlos Moreira   +5 more
doaj  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source