Results 121 to 130 of about 2,296,940 (310)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Diagnóstico diferencial das manifestações da sífilis e da Aids com líquen plano na boca
DST, 2012 A sífilis segue um curso semiológico em que aparece, desaparece e ressurge com variados sinais e sintomas, exigindo dos examinadores conhecimentos clínicos e laboratoriais que os conduzam ao seu diagnóstico.
Andrea B. Moleri +5 more
doaj
HIV/AIDS: Research and Palliative Care, 2020 Geofrey Ssekalembe, 1 Muhammad Atoillah Isfandiari, 1 Hendick Suprianto 2 1Faculty of Public Health, Universitas Airlangga, Surabaya, Indonesia; 2Dinas Kesehatan Kota Kediri, Kediri, IndonesiaCorrespondence: Geofrey SsekalembeFaculty of Public Health ...
Ssekalembe G, Isfandiari MA, Suprianto H
doaj
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
, 2019 HIV-AIDS adalah penyakit infeksi yang disebabkan oleh infeksi Human Immunodeficiency Virus. HIV dapat ditularkan melalui seks, transfusi darah, berbagi jarum suntik dan penularan ibu-ke-bayi (perinatal). Faktor risiko heteroseksual adalah yang tertinggi, yaitu 82,8%, diikuti oleh homoseksual sebesar 7,4% dan perinatal sebesar 4,0%.
openaire +3 more sources
Knowledge level and attitude of midwifery and nursing students regarding AIDS, Babol, 2000
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2003 Background and Objective: HIV attacks immune cells and causes impairment of immune system and disorder the defense of body against diseases. Since, 90% of infections occur in developing countries.
Sh Omidvar
doaj
HIV Research & Clinical PracticePerson-centered care (PCC) aims to improve client’s experiences in HIV care while advancing outcomes. This study team developed the PCC assessment tool (PCC-AT) to assess PCC service performance in HIV treatment settings in Ghana.
Jessica E. Posner +6 more
doaj +1 more source