Results 61 to 70 of about 5,887,441 (327)

Endothelial Cell Proteins as Biomarkers in Susac Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Susac syndrome (SS) is a rare CD8+ T cell–mediated microangiopathy affecting the brain, retina, and auditory labyrinth. Endothelial injury is thought to be a central mechanism; however, no circulating disease biomarkers are known. We performed targeted proteomic profiling to identify circulating endothelial‐associated proteins as ...
Rohit Benjamin, Yue Andy Qi, Ying Hao, Catherine DeMarino, Samuel Darko, Irene Cortese, Daniel S. Reich, María I. Gaitán, Steven Jacobson, Bridgett J. Billioux, Bryan Smith, Avindra Nath   +11 more
wiley   +1 more source

Global Perspective of Novel Therapeutic Strategies for the Management of NeuroAIDS

Biomolecular Concepts, 2018
Among Human immunodeficiency virus (HIV) infected individuals, around two-thirds of patients present with neuroAIDS, where HIV-associated neurocognitive disorders (HAND), and HIV-associated dementia (HAD) are the most prevailing neurological ...
Kumar Swatantra, Maurya Vimal K, Dandu Himanshu R, Bhatt Madan LB, Saxena Shailendra K   +4 more
doaj   +1 more source

NEUROTOXIC EFFECTS OF AZT ON DEVELOPING AND ADULT NEUROGENESIS

Frontiers in Neuroscience, 2015
Azidothymidine (AZT) is a synthetic, chain-terminating nucleoside analog used to treat HIV-1 infection. While AZT is not actively transported across the blood brain barrier, it does accumulate at high levels in cerebrospinal fluid, and subsequently ...
Meryem eDemir, Eric D Laywell
doaj   +1 more source

Data‐Driven SuStaIn Model of Disability Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether ordinal Subtype and Stage Inference (SuStaIn) applied to routine ALSFRS‐R item scores can identify reproducible disability progression patterns in amyotrophic lateral sclerosis (ALS) and provide clinically meaningful staging.
Giammarco Milella, Veria Vacchiano, Vittorio Velucci, Stefano Zoccolella, Rocco Liguori, Giovanni Defazio   +5 more
wiley   +1 more source

Economic Analysis of Hospital Palliative Care: Investigating Heterogeneity by Noncancer Diagnoses

MDM Policy & Practice, 2019
Background. Single-disease-focused treatment and hospital-centric care are poorly suited to meet complex needs in an era of multimorbidity. Understanding variation in palliative care’s association with treatment choices is essential to optimizing ...
Peter May, Charles Normand, Egidio Del Fabbro, Robert L. Fine, R. Sean Morrison, Isabel Ottewill, Chessie Robinson, J. Brian Cassel   +7 more
doaj   +1 more source

Beyond Frequency Bands: Complementary-Ensemble-Empirical-Mode-Decomposition-Enhanced Microstate Sequence Non-Randomness Analysis for Aiding Diagnosis and Cognitive Prediction of Dementia

Brain Sciences
Exploring the spatiotemporal dynamic patterns of multi-channel electroencephalography (EEG) is crucial for interpreting dementia and related cognitive decline.
Wang Wan, Zhongze Gu, Chung-Kang Peng, Xingran Cui   +3 more
doaj   +1 more source

Variation in HIV-1 R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors

Retrovirology, 2008
Background HIV-1 R5 viruses cause most of the AIDS cases worldwide and are preferentially transmitted compared to CXCR4-using viruses. Furthermore, R5 viruses vary extensively in capacity to infect macrophages and highly macrophage-tropic variants are ...
Simmonds Peter, Bell Jeanne, Burton Dennis R, Robinson James, Luzuriaga Katherine, Ankghuambom Chiambah, Brown Richard, Sullivan W Matthew, Duenas-Decamp Maria J, Peters Paul J, Ball Jonathan, Clapham Paul R   +11 more
doaj   +1 more source

The Lupus Damage Index Revision Program: Results From the Item Generation and Reduction Phases

Arthritis Care &Research, EarlyView.
Objective A data‐driven and expert/patient consensus‐based project to develop a revised Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology (ACR) Damage Index (SDI) is under way supported by SLICC, ACR, and the Lupus Foundation of America. Our objective is to report the item generation and reduction phase results
Burak Kundakci, Megan R. W. Barber, Ann E. Clarke, Sindhu R. Johnson, Anselm Mak, Hermine I. Brunner, Murat Inanc, Rosalind Ramsey‐Goldman, Guillermo Ruiz‐Irastorza, Ellen M. Ginzler, John G. Hanly, Alexandra Legge, Cynthia Aranow, Laurent Arnaud, Nathalie Costedoat‐Chalumeau, Dafna D. Gladman, Søren Jacobsen, Michelle Petri, Clovis A. Silva, Évelyne Vinet, Alexandre E. Voskuyl, SDI Revision Literature Review Groups, SDI Revision Delphi Panel, SDI Revision Item Reduction Committee, SDI Revision Clinical Domain Groups, Ian N. Bruce   +25 more
wiley   +1 more source

Neuropsychiatric symptoms in patients with Alzheimer’s disease with a vascular component

Annals of Agricultural and Environmental Medicine, 2014
objective. Vascular changes are observed in most cases of Alzheimer’s disease (AD). Observations of AD and vascular disease (VD) allow us to surmise that vascular changes may not only affect cognitive impairment in AD but may also have a negative ...
Mariola Bidzan, Leszek Bidzan, Maria Pachalska   +2 more
doaj  

Amyloid and tau cerebrospinal fluid biomarkers in HIV infection

BMC Neurology, 2009
Background Because of the emerging intersections of HIV infection and Alzheimer's disease, we examined cerebrospinal fluid (CSF) biomarkers related of amyloid and tau metabolism in HIV-infected patients.
Rosengren Lars, Hagberg Lars, Spudich Serena, Brew Bruce J, Cinque Paola, Blennow Kaj, Andreasson Ulf, Krut Jan, Gisslén Magnus, Price Richard W, Zetterberg Henrik   +10 more
doaj   +1 more source