Results 71 to 80 of about 5,887,441 (327)

Learning about design for dementia: lessons from a Japan–UK network [PDF]

A multidisciplinary Japan–UK Network identified cross-cultural and cross-national lessons for research aimed at improving the design of homes for people living with dementia.
Mitsuhiro Sado, Copland, Fiona, Ishikawa, Shogo, Dawson, Alison, Fiona Copland, Mio Ito, Lesley Palmer, Akihiro Koreki, Atsushi Omata, Alasdair Rutherford, Grant Gibson, Melanie Lovatt, Ito, Mio, Vikki McCall, Gibson, Grant, Martin Quirke, Rutherford, Alasdair, Phillips, Judith, Judith Phillips, Alison Dawson, McCall, Vikki, Satoko Hotta, Ryoji Noritake, Shogo Ishikawa, Daisuke Kiuchi, Koreki, Akihiro, Palmer, Lesley, Quirke, Martin, Kiuchi, Daisuke, Lovatt, Melanie, Alison Bowes, Hotta, Satoko, Bowes, Alison   +32 more
core   +1 more source

Individuals With Multijoint Osteoarthritis Demonstrate Larger Longitudinal Declines in Frailty: Data From the Canadian Longitudinal Study on Aging

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to test the hypothesis that multijoint osteoarthritis would modify the relation between time and frailty progression, in which more affected joints would lead to larger declines over six years compared to those without osteoarthritis using data from the Canadian Longitudinal Study on Aging.
Carson Halliwell, Rebecca Moyer, Myles W. O'Brien   +2 more
wiley   +1 more source

N-acetylcysteine prevents HIV gp 120-related damage of human cultured astrocytes: correlation with glutamine synthase dysfunction

BMC Neuroscience, 2007
Background HIV envelope gp 120 glycoprotein is released during active HIV infection of brain macrophages thereby generating inflammation and oxidative stress which contribute to the development of the AIDS-Dementia Complex (ADC).
Costa Nicola, Palma Ernesto, Sculco Francesca, Sacco Iolanda, Muscoli Carolina, Visalli Valeria, Colica Carmela, Rotiroti Domenicantonio, Mollace Vincenzo   +8 more
doaj   +1 more source

Engineered Nanotopography to Modulate Growth and Signaling of Neuronal Networks

Advanced Functional Materials, EarlyView.
This study examines the interaction between neurons and nanoscale topographies on engineered substrates. Neurons cultured on nanowires, nanopillars and nanoneedles exhibit enhanced neurite outgrowth, form more organized neuronal circuits, and display improved synaptic connectivity, compared to flat substrates.
Hao Nguyen Tran, Kalyan Shobhana, Zlatan Trifunovic, Dan Smith, Michael Stuiber, Chennupati Jagadish, Mirella Dottori, Andrea J. O'Connor, Vini Gautam   +8 more
wiley   +1 more source

Design and Pharmaceutical Evaluation of a Nano-Enabled Crosslinked Multipolymeric Scaffold for Prolonged Intracranial Release of Zidovudine

Journal of Pharmacy & Pharmaceutical Sciences, 2013
Purpose. Nanomedicine explores and allows for the development of drug delivery devices with superior drug uptake, controlled release and fewer drug side-effects.
Sheri-Lee Harilall, Yahya E Choonara, Girish Modi, Lomas K Tomar, Charu Tyagi, Pradeep Kumar, Lisa C du Toit, Sunny E Iyuke, Michael P Danckwerts, Viness Pillay   +9 more
doaj   +1 more source

‘Facing dementia Together’: Post diagnostic support pilot for people with dementia and their families in Renfrewshire and East Renfrewshire - Final Project Evaluation Report [PDF]

, 2011
This document reports on the evaluation, conducted between January 2010 and April 2011, of a post diagnostic support project for people with dementia and their family carers living in Renfrewshire and East Renfrewshire.
Innes, Anthea, Macintosh, Sherry, Kelly, Fiona, Robertson, Jane, Bowes, Alison   +4 more
core  

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source

Current evidence for a role of the Kynurenine pathway of tryptophan metabolism in Multiple Sclerosis

Frontiers in Immunology, 2016
The kynurenine pathway (KP) is the major metabolic pathway of the essential amino acid tryptophan (TRP). Stimulation by inflammatory molecules such as interferon-γ (IFN-γ) is the trigger for induction of the KP, driving a complex cascade of production of
Michael D. Lovelace, Michael D. Lovelace, Bianca Varney, Gayathri Sundaram, Nunzio Franco, Mei Li Ng, Saparna Pai, Chai K. Lim, Bruce J. Brew, Bruce J. Brew, Bruce J. Brew   +10 more
doaj   +1 more source

AIDS Medicine and Miracles : v.5:no.1(1995)

, 1995
This issue of AIDS Medicine & Miracles discusses the achievements of Steven Abbott, founder of the Stop AIDS Project. Sam Gallegos is also featured in an article that discusses her activism in the fight against AIDS. Also mentioned is the new director of

core  

Quantification of Phosphorylated Tau Protein in Alzheimer's Disease Patients’ Fluids With Electrolyte‐Gated Organic Transistor Biosensors

Advanced Healthcare Materials, EarlyView.
Dementia syndrome affects millions of people in the world, and Alzheimer's disease (AD) is the most common cause. We report the detection of the specific biomarker for AD, p‐tau‐181, from physiological to pathological concentrations in cerebrospinal fluid using an electrolyte‐gated organic transistor biosensor.
Marcello Berto, Pamela A. Manco Urbina, Alessandro Paradisi, Matteo Sensi, Najara Iacovino, Chiara Carbone, Roberta Bedin, Marcello Pinti, Fabio Biscarini, Giovanna Zamboni, Carlo A. Bortolotti   +10 more
wiley   +1 more source