Results 111 to 120 of about 53,072 (310)
IgG3 collaborates with IgG1 and IgA to recruit effector function in RV144 vaccinees
JCI Insight, 2020 While the RV144 HIV vaccine trial led to moderately reduced risk of HIV acquisition, emerging data from the HVTN702 trial point to the critical need to reexamine RV144-based correlates of reduced risk of protection.
Stephanie Fischinger +10 more
doaj +1 more source
, 2010 Genetic immunization, also known as DNA or polynucleotide immunisation, is well documented to induce broad-based immunity in various animal models of infectious and non-infectious diseases.
Shan, Songhua
core
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
How does the impact of an HIV/AIDS information campaign vary with educational attainment ? Evidence from rural Uganda [PDF]
The responsiveness to information is thought to be one channel through which education affects health outcomes. The author tests this hypothesis by examining the effectiveness of an information campaign that aims at preventing the HIV/AIDS epidemic in ...
De Walque, Damien
core
The marginal willingness-to-pay for attributes of a hypothetical HIV vaccine
, 2012 This paper estimates the marginal willingness-to-pay for attributes of a hypothetical HIV vaccine using discrete choice modeling. We use primary data from 326 respondents from Bangkok and Chiang Mai, Thailand, in 2008–2009, selected using purposive ...
Newman, Peter A. +15 more
core +1 more source
Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro
Advanced Science, EarlyView.The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel +15 more
wiley +1 more source
Advantages of Broad-Spectrum Influenza mRNA Vaccines and Their Impact on Pulmonary Influenza
VaccinesInfluenza poses a significant global health challenge due to its rapid mutation and antigenic variability, which often leads to seasonal epidemics and frequent outbreaks.
Ziqi Cheng, Junfeng Ma, Chenyan Zhao
doaj +1 more source
The HIV/AIDS Pandemic: A Sign of Instability in a Complex Global System
, 2002 Intense scientific work on HIV/AIDS has led to the development of effective combination drug therapies and there is hope that effective vaccines will soon be produced.
Benatar, Solomon
core +1 more source
Advanced Science, EarlyView.This study reveals that the Fgl2‐FcγRIIB signaling axis is a key mechanism by which MDSCs mediate tumor immune evasion. Tumor‐derived exosomes systemically activate MDSCs via this pathway, positioning this axis as a promising broad‐spectrum target for cancer immunotherapy.
Fenglin Lin +12 more
wiley +1 more source
Clinical studies of experimental vaccines
, 2006 PURPOSE OF REVIEW: The scope of this review is to provide the current status of HIV vaccine clinical development. A series of issues regarding the type of immune response stimulated by the candidate vaccines in the pipeline, the advances in the immune ...
Bart, P.A. +5 more
core +1 more source