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Science, 2008
A quarter century of scientific discovery has been applied to developing an AIDS vaccine, yet this goal remains elusive. Specific characteristics of the virus, including the extreme genetic variability in circulating viral isolates worldwide, biological properties of HIV that impede immune attack, and a high mutation rate that allows for rapid escape ...
Bruce D, Walker, Dennis R, Burton
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A quarter century of scientific discovery has been applied to developing an AIDS vaccine, yet this goal remains elusive. Specific characteristics of the virus, including the extreme genetic variability in circulating viral isolates worldwide, biological properties of HIV that impede immune attack, and a high mutation rate that allows for rapid escape ...
Bruce D, Walker, Dennis R, Burton
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JAMA, 1994
Worldwide, the human immunodeficiency virus type 1 (HIV-1) has already infected 10 million to 15 million people. With an estimated 5000 to 10 000 new infections occurring each day, 30 million to 40 million people will be infected by the year 2000. 1 In developing countries, where more than 80% of new infections are occurring, the virus is predominantly
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Worldwide, the human immunodeficiency virus type 1 (HIV-1) has already infected 10 million to 15 million people. With an estimated 5000 to 10 000 new infections occurring each day, 30 million to 40 million people will be infected by the year 2000. 1 In developing countries, where more than 80% of new infections are occurring, the virus is predominantly
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Vaccine, 1999
In spite of extensive prevention programs, the HIV epidemics is still spreading worldwide, in particularly in developing countries where clade C viruses predominate. WHO estimates that there are 16, 000 new cases of HIV infection daily and that 100 M individuals will be infected by the end of the next decade.
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In spite of extensive prevention programs, the HIV epidemics is still spreading worldwide, in particularly in developing countries where clade C viruses predominate. WHO estimates that there are 16, 000 new cases of HIV infection daily and that 100 M individuals will be infected by the end of the next decade.
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Clinical Pharmacology & Therapeutics, 2007
Development of an HIV/AIDS vaccine has been slow because classical approaches to vaccine development have not yielded a vaccine. Encouragingly, new approaches using recombinant viral vectors, DNA vaccines, and combinations of different vectors in heterologous prime/boost regimens are yielding vaccines capable of controlling virulent immunodeficiency ...
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Development of an HIV/AIDS vaccine has been slow because classical approaches to vaccine development have not yielded a vaccine. Encouragingly, new approaches using recombinant viral vectors, DNA vaccines, and combinations of different vectors in heterologous prime/boost regimens are yielding vaccines capable of controlling virulent immunodeficiency ...
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Science, 1998
In recent months, the U.S. National Institutes of Health (NIH) human immunodeficency virus (HIV) vaccine research program has been criticized by a few activists and public health figures who serve on, or have provided testimony to, the President's Advisory Committee on HIV/AIDS (PACHA) (M. Balter,
Moises Agosto +56 more
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In recent months, the U.S. National Institutes of Health (NIH) human immunodeficency virus (HIV) vaccine research program has been criticized by a few activists and public health figures who serve on, or have provided testimony to, the President's Advisory Committee on HIV/AIDS (PACHA) (M. Balter,
Moises Agosto +56 more
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Trends in Microbiology, 2001
AIDS researchers have uncovered another clue as to what protects at-risk but HIV-free women. A recent study published in J. Clin. Invest. follows up on previous work carried out with sex workers from Nairobi that suggested a genetic basis for their protected status.
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AIDS researchers have uncovered another clue as to what protects at-risk but HIV-free women. A recent study published in J. Clin. Invest. follows up on previous work carried out with sex workers from Nairobi that suggested a genetic basis for their protected status.
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Lessons for AIDS vaccine development from non-AIDS vaccines.
AIDS research and human retroviruses, 1999Critical misconceptions about vaccine development have arisen in the context of acquired immunodeficiency syndrome (AIDS) vaccine research. These include: the goal of vaccination; the biological relevance and predictive value of animal models; the meaning of "correlates of protective immunity"; the nature and duration of vaccine-induced immune ...
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