Results 41 to 50 of about 118,080 (265)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Study on the Direct Current Breakdown Characteristics and Influence of Electric Field Distribution in Water Droplets in Rod–Plate Air Gaps

Applied Sciences
This study primarily simulates the flashover phenomenon between the metal fittings (rods) and the skirt surface (plates) of insulators when water droplets traverse between them under heavy rain conditions.
Jianli Zhao, Zhaoyang Du, Jiankun Zhao, Song Fu, Bin Cao   +4 more
doaj   +1 more source

Use of fractional-conductor windings and semi-magnetic slot wedges in synchronous machines

The Journal of Engineering, 2019
This paper discusses two methods of altering the harmonic content of the spatial air-gap flux density waveform in synchronous machines (generators and motors).
Christopher Donaghy-Spargo, Anthony Spargo, Anthony Spargo   +2 more
doaj   +1 more source

Analytical study of air-gap surface force – application to electrical machines

Open Physics, 2020
The Maxwell stress tensor (MST) method is commonly used to accurately compute the global efforts, such as electromagnetic torque ripple and unbalanced electromagnetic forces in electrical machines.
Pile Raphaël, Le Besnerais Jean, Parent Guillaume, Devillers Emile, Henneron Thomas, Le Menach Yvonnick, Lecointe Jean-Philippe   +6 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Utilisation of grain-oriented electrical steel in permanent magnet fractional-slot modular machines

The Journal of Engineering, 2019
The performance improvement of using grain-oriented electrical steels (GOES) in the stator of PM fractional-slot modular machines is analysed in this study.
Jaime Maraví-Nieto, Ziad Azar, Arwyn S. Thomas, Zi-Qiang Zhu   +3 more
doaj   +1 more source

A machine learning‐based approach for dielectric strength prediction of long air gaps with engineering configurations

IET Generation, Transmission & Distribution, 2022
It is a long‐term goal in external insulation studies to determine the discharge voltages of complicated engineering gaps by simulation methods.
Zhibin Qiu, Zijian Wu, Louxing Zhang, Yu Song, Jianben Liu   +4 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Electrical field distribution of 35 KV Igla under polluted and ice-covered situation at power frequency

The Journal of Engineering, 2019
Lightning striking on power system may lead to severe accident and huge losses, which is the reason why line arresters are needed. During operation, the electrical field concentration in line arrester may lead to ablation and accelerated aging of ...
Guo Jie, Wu Xiaoke, Li Mengzhen, Zhao Zexin, Xu Long   +4 more
doaj   +1 more source