Results 51 to 60 of about 130,424 (262)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The effect of very small air gaps on small field dosimetry

, 2012
The purpose of this study was to investigate the effect of very small air gaps (less than 1 mm) on the dosimetry of small photon fields used for stereotactic treatments. Measurements were performed with optically stimulated luminescent dosimeters (OSLDs)
Lye, J., Crowe, S., Kairn, T., Kairn, Tanya, Trapp, J., Asena, Andre, Crowe, S.B., Fielding, Andrew L., Kenny, J., Knight, R.T., Hill, B., Langton, C.M., Trapp, J.V., Middlebrook, Nigel, Langton, Christian M., Hill, Brendan, Knight, Richard, Knight, R., Perera, Lakshal, Lehmann, J, Dunn, L., Trapp, Jamie, Charles, P.H., Dunn, Leon, Kenny, John, Charles, Paul, Cornelius, Iwan, Lehmann, J., Crowe, Scott, Charles, P.   +29 more
core   +1 more source

Multilayer External Enclosing Wall Structures with Air Gaps or Channels

, 2023
Precise meanings of thermophysical processes taking place in air gaps have decisive importance in composite cladding structure systems’ calculation and modeling.
Kanat Baibolov, Askhat Tagybayev, Bayan Sapargaliyeva, Bolat Duissenbekov, Islambek Baidilla, Nurlan Zhangabay, Aizhan Izbassar, Bekbulat Shakeshev, Akmaral Utelbayeva, Alexandr Kolesnikov, Pavel Kozlov   +10 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Study on the Direct Current Breakdown Characteristics and Influence of Electric Field Distribution in Water Droplets in Rod–Plate Air Gaps

Applied Sciences
This study primarily simulates the flashover phenomenon between the metal fittings (rods) and the skirt surface (plates) of insulators when water droplets traverse between them under heavy rain conditions.
Jianli Zhao, Zhaoyang Du, Jiankun Zhao, Song Fu, Bin Cao   +4 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Use of fractional-conductor windings and semi-magnetic slot wedges in synchronous machines

The Journal of Engineering, 2019
This paper discusses two methods of altering the harmonic content of the spatial air-gap flux density waveform in synchronous machines (generators and motors).
Christopher Donaghy-Spargo, Anthony Spargo, Anthony Spargo   +2 more
doaj   +1 more source

Analytical study of air-gap surface force – application to electrical machines

Open Physics, 2020
The Maxwell stress tensor (MST) method is commonly used to accurately compute the global efforts, such as electromagnetic torque ripple and unbalanced electromagnetic forces in electrical machines.
Pile Raphaël, Le Besnerais Jean, Parent Guillaume, Devillers Emile, Henneron Thomas, Le Menach Yvonnick, Lecointe Jean-Philippe   +6 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Dielectric barriers under lightning impulse stress: Breakdown and discharge-dielectric interaction in short non-uniform air gaps [PDF]

, 2019
Dielectric-air insulation systems can reduce the carbon footprint of medium voltage switchgear, as they can replace SF6-insulated systems. Such replacement is, however, not easy, as the devices are typically compact and complex, with strongly ...
Meyer, Hans Kristian Hygen
core   +1 more source