Results 51 to 60 of about 118,080 (265)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

The Wide‐Band Multisection Wilkinson Power Divider Based on RGW for X‐ and Ku‐Band Applications

open access: yesIET Microwaves, Antennas & Propagation
This paper presents the design, simulation and fabrication of a wideband Wilkinson power divider (WPD) based on ridge gap waveguide (RGW) technology for operation in the X‐ and Ku‐band frequency range (8–18 GHz).
Reza Afroozeh   +2 more
doaj   +1 more source

Accuracy improvement for complex harmonic analysis modelling of a wound field synchronous generator

open access: yesThe Journal of Engineering, 2019
Complex harmonic analysis (CHA) provides a computationally efficient alternative to finite element analysis (FEA) for modelling multi-phase wound field synchronous machines. This paper presents three methods that could improve the accuracy of the CHA: by
Xiaotao Zhang   +2 more
doaj   +1 more source

Claw‐pole magnetic levitation torque motor for 2D valve with automatic neutral adjustment

open access: yesIET Electric Power Applications, 2023
In order to solve the problems of complex structure and the difficulty of neutral adjustment of the existing 2D valve electro‐mechanical converter, a kind of claw pole magnetic levitation torque motor (CPMLTM) was proposed, which automatically suspended ...
Jiahui Huang   +3 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

Impact of Self-Contained Breathing Apparatus on Air Gaps in Structural Firefighting Personal Protective Clothing

open access: yesApplied Sciences
The self-contained breathing apparatus (SCBA) is an integral part of the structural firefighting personal protective equipment (PPE) ensemble. However, when donned, it adds significant weight and restriction, interfering with the fit of the turnout suit ...
Josephine Bolaji, Meredith McQuerry
doaj   +1 more source

High‐Contrast Optical Modulation from Strain‐Induced Nanogaps at 3D Heterogeneous Interfaces

open access: yesAdvanced Science, 2020
The realization of high‐contrast modulation in optically transparent media is of great significance for emerging mechano‐responsive smart windows. However, no study has provided fundamental strategies for maximizing light scattering during mechanical ...
Donghwi Cho   +11 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Multilayer air gap winding designs for electric machines: theory, design, and characterisation

open access: yesThe Journal of Engineering, 2019
Here, the authors present a magnetic circuit design with a multilayer air gap winding. This design provides a new degree of freedom in the design process.
Norman Borchardt   +4 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

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