Results 61 to 70 of about 130,424 (262)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Utilisation of grain-oriented electrical steel in permanent magnet fractional-slot modular machines

open access: yesThe Journal of Engineering, 2019
The performance improvement of using grain-oriented electrical steels (GOES) in the stator of PM fractional-slot modular machines is analysed in this study.
Jaime Maraví-Nieto   +3 more
doaj   +1 more source

A machine learning‐based approach for dielectric strength prediction of long air gaps with engineering configurations

open access: yesIET Generation, Transmission & Distribution, 2022
It is a long‐term goal in external insulation studies to determine the discharge voltages of complicated engineering gaps by simulation methods.
Zhibin Qiu   +4 more
doaj   +1 more source

Advancing the U.S. Air Force's force-development initiative /

open access: yes, 2007
A mismatch in the late 1990s between the qualifications needed for key general officer positions and the backgrounds of available candidates stimulated RAND research and then an extensive U.S.
Moore, S. Craig, Brauner, Marygail K.
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

The Wide‐Band Multisection Wilkinson Power Divider Based on RGW for X‐ and Ku‐Band Applications

open access: yesIET Microwaves, Antennas & Propagation
This paper presents the design, simulation and fabrication of a wideband Wilkinson power divider (WPD) based on ridge gap waveguide (RGW) technology for operation in the X‐ and Ku‐band frequency range (8–18 GHz).
Reza Afroozeh   +2 more
doaj   +1 more source

Electrical field distribution of 35 KV Igla under polluted and ice-covered situation at power frequency

open access: yesThe Journal of Engineering, 2019
Lightning striking on power system may lead to severe accident and huge losses, which is the reason why line arresters are needed. During operation, the electrical field concentration in line arrester may lead to ablation and accelerated aging of ...
Guo Jie   +4 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Impact of Self-Contained Breathing Apparatus on Air Gaps in Structural Firefighting Personal Protective Clothing

open access: yesApplied Sciences
The self-contained breathing apparatus (SCBA) is an integral part of the structural firefighting personal protective equipment (PPE) ensemble. However, when donned, it adds significant weight and restriction, interfering with the fit of the turnout suit ...
Josephine Bolaji, Meredith McQuerry
doaj   +1 more source

Accuracy improvement for complex harmonic analysis modelling of a wound field synchronous generator

open access: yesThe Journal of Engineering, 2019
Complex harmonic analysis (CHA) provides a computationally efficient alternative to finite element analysis (FEA) for modelling multi-phase wound field synchronous machines. This paper presents three methods that could improve the accuracy of the CHA: by
Xiaotao Zhang   +2 more
doaj   +1 more source

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