Results 61 to 70 of about 3,597,235 (308)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Other title: Air National Guard in Kansas
, 1978 application/pdfA set of 8 documents provided by the 190th Air Refueling Wing and the 184th Intelligence Wing, Kansas Air National Guard, with resources and information about the Air National Guard in Kansas.Twenty Years With the Same Lady (June 1978 ...
Kansas. Air National Guard.
core +1 more source
Applied SciencesThe self-contained breathing apparatus (SCBA) is an integral part of the structural firefighting personal protective equipment (PPE) ensemble. However, when donned, it adds significant weight and restriction, interfering with the fit of the turnout suit ...
Josephine Bolaji, Meredith McQuerry
doaj +1 more source
High‐Contrast Optical Modulation from Strain‐Induced Nanogaps at 3D Heterogeneous Interfaces
Advanced Science, 2020 The realization of high‐contrast modulation in optically transparent media is of great significance for emerging mechano‐responsive smart windows. However, no study has provided fundamental strategies for maximizing light scattering during mechanical ...
Donghwi Cho +11 more
doaj +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Multilayer air gap winding designs for electric machines: theory, design, and characterisation
The Journal of Engineering, 2019 Here, the authors present a magnetic circuit design with a multilayer air gap winding. This design provides a new degree of freedom in the design process.
Norman Borchardt +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source