Results 71 to 80 of about 740,856 (310)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
External walls partially filled with insulation, and the potential to "top-up" the residual cavity. [PDF]
, 2015 This review found that the connecting voids in partially filled cavity walls leads to considerable variation in thermal performance. Whilst photographic records found considerable evidence of gaps in the insulation resulting from poor site practice and ...
Gorse, C, Miles-Shenton, D, Thomas, F
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
When the going gets rough – studying the effect of surface roughness on the adhesive abilities of tree frogs [PDF]
, 2016 Tree frogs need to adhere to surfaces of various roughnesses in their natural habitats; these include bark, leaves and rocks. Rough surfaces can alter the effectiveness of their toe pads, due to factors such as a change of real contact area and abrasion
Barnes, W. Jon P. +4 more
core +2 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Local magnetic measurements in magnetic circuits with highly nonuniform electromagnetic fields [PDF]
, 2009 In this paper, local magnetic measurements are carried out in magnetic circuits with highly non uniform electromagnetic field patterns, including excitation winding and/or air gaps, as in the case of rotating electrical machines.
Dupré, Luc +1 more
core
Harnessing Geometric Frustration to Form Band Gaps in Acoustic Channel Lattices
, 2016 We demonstrate both numerically and experimentally that geometric frustration in two-dimensional periodic acoustic networks consisting of arrays of narrow air channels can be harnessed to form band gaps (ranges of frequency in which the waves cannot ...
Bertoldi, Katia +8 more
core +1 more source
The Journal of Engineering, 2020 This study analyses a double Y shaft 30° winding for six-phase fault-tolerant permanent magnet synchronous motors and introduces a novel modular 18-slot stator topology used in high-performance electric vehicles with unequal teeth width and unequal slot ...
Zhong An Yu +3 more
doaj +1 more source
Homologous expression and purification of human HAX‐1 for structural studies
FEBS Open Bio, EarlyView.This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley +1 more source