Results 41 to 50 of about 456,021 (313)

Prediction of Capacity Regulations in Airspace Based on Timing and Air Traffic Situation

Aerospace, 2023
The Air Traffic Control (ATC) system suffers from an ever-increasing demand for aircraft, leading to capacity issues. For this reason, airspace is regulated by limiting the entry of aircraft into the airspace.
Francisco Pérez Moreno, Víctor Fernando Gómez Comendador, Raquel Delgado-Aguilera Jurado, María Zamarreño Suárez, Rosa María Arnaldo Valdés   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dynamic Flight Tracking: Designing System for Multirotor UAVs With Pixhawk Autopilot Data Verification

IEEE Access
The increasing diversity of multirotor unmanned aerial vehicles (UAV) designs poses significant challenges in evaluating their flight characteristics and performance parameters.
Stanislav Kusmirek, Vladimir Socha, Tomas Malich, Lubos Socha, Karel Hylmar, Lenka Hanakova   +5 more
doaj   +1 more source

U.S. intra-industry trade in air transport services: measurement and results [PDF]

Transport Problems, 2015
The paper deals with the measurement of intra-industry trade (IIT) in air transport services and it´s components (passenger and air cargo services) among the United States of America and 31 chosen countries in time period 2000 - 2011.
Martina BLAŠKOVÁ, Filip ŠKULTÉTY
doaj  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Characteristics of China’s air transport industry [PDF]

, 2021
In the past decade, high-speed rail (HSR) has emerged as a significant transport mode in China, posing a serious threat to China's air transport sector because of its potential to reduce air travel demand.
Zhang, C., Zhang, Yahua (Shane), Yarde, K.   +2 more
core   +1 more source

Emission Reduction Potential of Hydrogen-Powered Aviation Between Airports in Proximity of Seaports

Aerospace
Green hydrogen will play a crucial role in the future of emission reduction in air traffic in the long-term, as it will completely eliminate CO2 emissions and significantly reduce other pollutants such as contrails and nitrogen oxides.
Nico Flüthmann, Tim Schunkert, Marc Gelhausen, Alexandra Leipold   +3 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source