Results 61 to 70 of about 5,093,691 (299)
Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
FEBS Open Bio, EarlyView.Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source
DronesIntegrating Unmanned Aerial Vehicles (UAVs) into urban airspace requires a risk-aware approach to strategic flight planning and trajectory optimization, particularly for beyond-visual-line-of-sight operations. Existing regulatory frameworks impose strict
Hannes Braßel +3 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers +19 more
wiley +1 more source
Validation Framework for Automated Aircraft Load Control Operations
EngThis paper presents a validation framework for automated aircraft mass and balance operations, combining statistical process control with integrated risk scoring and addressing the critical gap between traditional centralised load control and emerging ...
Ivan Jakovljević +2 more
doaj +1 more source
Interdependent Uncertainty Handling in Trajectory Prediction
Aerospace, 2019 The concept of 4D trajectory management relies on the prediction of aircraft trajectories in time and space. Due to changes in atmospheric conditions and complexity of the air traffic itself, the reliable prediction of system states is an ongoing ...
Thomas Zeh +2 more
doaj +1 more source
Arthritis Care &Research, Accepted Article.Biomedical research involving United States Veterans continues to advance healthcare beyond the Veterans Health Administration. This is particularly true in rheumatoid arthritis (RA), where Veteran‐centric research has uncovered novel insights into pathogenesis, risk factors, and disease manifestations, informing clinical care and research across both ...
Austin M. Wheeler +20 more
wiley +1 more source
A Q‐Learning Algorithm to Solve the Two‐Player Zero‐Sum Game Problem for Nonlinear Systems
International Journal of Adaptive Control and Signal Processing, Volume 39, Issue 3, Page 566-581, March 2025.A Q‐learning algorithm to solve the two‐player zero‐sum game problem for nonlinear systems. ABSTRACT This paper deals with the two‐player zero‐sum game problem, which is a bounded L2$$ {L}_2 $$‐gain robust control problem. Finding an analytical solution to the complex Hamilton‐Jacobi‐Issacs (HJI) equation is a challenging task.
Afreen Islam +2 more
wiley +1 more source