Results 21 to 30 of about 941,937 (358)

Evaluation of the routine implementation of pulse oximeters into integrated management of childhood illness (IMCI) guidelines at primary health care level in West Africa: the AIRE mixed-methods research protocol

BMJ Paediatrics Open, 2022
Background The AIRE operational project will evaluate the implementation of the routine Pulse Oximeter (PO) use in the integrated management of childhood illness (IMCI) strategy for children under-5 in primary health care centers (PHC) in West Africa ...
E. Gres, Ibrahima Sory Diallo, Cédric Besnier, A. Diakité, Z. Zair, S. Ouédraogo Yugbaré, G. Hedible, A. Sawadogo, Désiré Kargougou, J. Kolié, B. Meda, S. Busière, F. Lamontagne, V. Ridde, V. Leroy   +14 more
semanticscholar   +1 more source

Aire and Fezf2, two regulators in medullary thymic epithelial cells, control autoimmune diseases by regulating TSAs: Partner or complementer?

Frontiers in Immunology, 2022
The expression of tissue-specific antigens (TSAs) in medullary thymic epithelial cells (mTECs) is believed to be responsible for the elimination of autoreactive T cells, a critical process in the maintenance of central immune tolerance. The transcription
Y. Qi, Rongchao Zhang, Yao Lu, Xue-Yang Zou, Wei Yang   +4 more
semanticscholar   +1 more source

GWAS for autoimmune Addison’s disease identifies multiple risk loci and highlights AIRE in disease susceptibility

Nature Communications, 2021
Autoimmune Addison’s disease (AAD) is characterized by the autoimmune destruction of the adrenal cortex. Low prevalence and complex inheritance have long hindered successful genetic studies.
D. Eriksson, E. C. Røyrvik, M. Aranda-Guillén, A. Berger, Nils Landegren, H. Artaza, Å. Hallgren, M. A. Grytaas, Sara Ström, E. Bratland, I. Botusan, B. Oftedal, L. Breivik, M. Vaudel, Ø. Helgeland, A. Falorni, A. Jørgensen, A. Hulting, J. Svartberg, O. Ekwall, K. Fougner, J. Wahlberg, B. Nedrebø, P. Dahlqvist, Helge Nevena Sigfrid Christine Geir Siri Tore Julsrud Ja Ræder Jovanovic Reisegg Hølleland Carlsen Berg Egg, Helge Ræder, N. Jovanovic, Sigfrid Christine Reisegg, Geir Hølleland, Siri Carlsen, T. J. Berg, J. Eggesbø, T. Svendsen, Kari Lima, I. Nermoen, R. Whitfield, S. Sollid, D. Aarskog, E. Korsgaard, Solveig Sæta, T. Finnes, S. Valland, C. Fossum, Elisabeth Brevik, R. B. Moe, Margrethe Svendsen, Aleksandra J Debowska, Petya Milova, S. Holte, A. Tomkowicz, Dag Sørmo, A. Svare, Marthe Landsverk Rensvik, Randi Revheim, T. Haug, Ivar Blix, Lars Peter Jensen, Anna-Karin Anna-Lena Bengt Berit Erik Gudmundur Jakob Jeanett Åkerman Hulting Lindberg Kriström Waldenström Joha, A. Åkerman, B. Lindberg, B. Kriström, E. Waldenström, G. Johannsson, J. Skov, K. Duchén, M. Isaksson, M. Elfving, M. H. Stenlid, O. Nilsson, O. Kämpe, O. Ekwall, P. Dahlqvist, Ragnhildur Bergthorsdottir, R. Nergårdh, S. Björnsdóttir, S. Bensing, T. Olsson, P. Knappskog, A. Wolff, S. Bensing, S. Johansson, O. Kämpe, E. Husebye   +82 more
semanticscholar   +1 more source

¿Qué respiramos? La construcción de saberes y conciencia ambiental entre la universidad y la escuela secundaria, a través de la extensión universitaria

Universidad en Diálogo, 2021
El objetivo de este trabajo es abordar una problemática ambiental en relación con la salud humana, para responder a la inquietud presentada por estudiantes y docentes de dos escuelas secundarias de la ciudad de San Luis (Argentina).
Andrea Celeste Isaguirre, Mario Franco Moyano   +1 more
doaj   +1 more source

Aire suppresses CTLA-4 expression from the thymic stroma to control autoimmunity.

Cell Reports, 2022
Impaired production of thymic regulatory T cells (Tregs) is implicated in the development of Aire-dependent autoimmunity. Because Tregs require agonistic T cell receptor stimuli by self-antigens to develop, reduced expression of self-antigens from ...
J. Morimoto, Minoru Matsumoto, Ryuichiro Miyazawa, H. Yoshida, Koichi Tsuneyama, M. Matsumoto   +5 more
semanticscholar   +1 more source

Extrathymic AIRE-expressing cells: Friends or foes in autoimmunity and cancer?

Autoimmunity Reviews, 2022
Auto-immune regulator (AIRE) is a transcription factor that is mainly known for its crucial role in the thymus. Here, AIRE ensures central tolerance by promoting the expression of peripheral tissue antigens in thymic epithelial cells, which is essential ...
G. V. van Laar, J. V. van Hamburg, S. Tas   +2 more
semanticscholar   +1 more source

Apeced in Turkey: a case report and insights on genetic and phenotypic variability [PDF]

, 2018
APECED is a rare monogenic recessive disorder caused by mutations in the AIRE gene. In this manuscript, we report a male Turkish patient with APECED syndrome who presented with chronic mucocutaneous candidiasis associated with other autoimmune ...
Alessandra Fierabraccia, Corrado Betterle, FRASCA, FEDERICA, Marsha Pellegrino, Sara Sebnem Kilic   +4 more
core   +1 more source

Phylogeny, Structure, Functions, and Role of AIRE in the Formation of T-Cell Subsets

Cells, 2022
It is well known that the most important feature of adaptive immunity is the specificity that provides highly precise recognition of the self, altered-self, and non-self.
D. Shevyrev, V. Tereshchenko, V. Kozlov, S. Sennikov   +3 more
semanticscholar   +1 more source

Aire‐dependent transcripts escape Raver2‐induced splice‐event inclusion in the thymic epithelium

EMBO Reports, 2022
Aire allows medullary thymic epithelial cells (mTECs) to express and present a large number of self‐antigens for central tolerance. Although mTECs express a high diversity of self‐antigen splice isoforms, the extent and regulation of alternative splicing
Francine Padonou, V. Gonzalez, N. Provin, Sümeyye Yayilkan, Nada Jmari, Julia Maslovskaja, K. Kisand, P. Peterson, M. Irla, M. Giraud   +9 more
semanticscholar   +1 more source

Lecciones aprendidas en el conflicto de los Balcanes

Arbor: Ciencia, Pensamiento y Cultura, 2002
Condensado de documentos no clasificados procedentes del Mando Aéreo de Combate del Ejército del Aire El autor ha sabido aquí extraer y condensar, a partir de documentos no clasificados del Mando Aéreo de Combate, una síntesis de las eficiencias ...
Angel de Cózar López
doaj   +1 more source