Results 31 to 40 of about 941,937 (358)
Annales de Didactique et de Sciences Cognitives, 2020 This article presents a comparative study of French and Quebec textbooks on the notion of area. Several research studies have raised students’ difficulties in understanding the concept of area, and recent work suggests studying these difficulties in ...
Nathalie Silvia Anwandter Cuellar +1 more
doaj +1 more source
Neonatal Tolerance Revisited: A Perinatal Window for Aire Control of Autoimmunity [PDF]
, 2012 There has long been conceptual and experimental support for, but also challenges to, the notion that the initial period of the immune system's development is particularly important for the establishment of tolerance to self.
Benoist, Christophe O. +3 more
core +1 more source
Spectrum of germline AIRE mutations causing APS-1 and familial hypoparathyroidism
European Journal of Endocrinology, 2022 Objective The autoimmune polyendocrine syndrome type 1 (APS-1) is an autosomal recessive disorder characterised by immune dysregulation and autoimmune endocrine gland destruction. APS-1 is caused by biallelic mutations affecting the autoimmune regulator (
T. Cranston +9 more
semanticscholar +1 more source
AIRE acetylation and deacetylation: effect on protein stability and transactivation activity [PDF]
, 2014 The AIRE protein plays a remarkable role as a regulator of central tolerance by controlling the promiscuous expression of tissue-specific antigens in thymic medullary epithelial cells.
Alessandra Meloni +7 more
core +2 more sources
El cielo único europeo, implicaciones para la defensa
Arbor: Ciencia, Pensamiento y Cultura, 2002 Su autor nos presenta un tema de gran actualidad y que posiblemente deberá ser tratado durante la Presidencia española de la Unión (primer semestre de 2002), a fin de conseguir que el llamado «Cielo Único Europeo» sea una realidad en diciembre de 2004 ...
Enrique Pina Díaz
doaj +1 more source
Post-Aire Maturation of Thymic Medullary Epithelial Cells Involves Selective Expression of Keratinocyte-Specific Autoantigens [PDF]
, 2012 Extent: 16p.The autoimmune regulator (Aire)-directed ectopic expression of tissue-specific antigens (TSAs) by mature medullary thymic epithelial cells (mTECs) has been viewed as an essential mechanism in the induction of central tolerance.
Xiaoping eWang +6 more
core +1 more source
AIRE deficiency, from preclinical models to human APECED disease
Disease Models & Mechanisms, 2021 Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) is a rare life-threatening autoimmune disease that attacks multiple organs and has its onset in childhood.
Marine Besnard +4 more
semanticscholar +1 more source
Extrathymic Aire-expressing cells support maternal-fetal tolerance
Science immunology, 2021 Maternal extrathymic Aire-expressing cells support maternal-fetal tolerance and prevent intrauterine growth restriction in mice. Aire-expressing cells defend the fetus The normal maternal immune system adapts to pregnancy by learning to tolerate both ...
Eva M. Gillis-Buck +7 more
semanticscholar +1 more source
Hepatology, EarlyView., 2022 Natural history of liver disease in a large international cohort of children with Alagille syndrome: Results from the GALA study. Abstract Background and Aims Alagille syndrome (ALGS) is a multisystem disorder, characterized by cholestasis. Existing outcome data are largely derived from tertiary centers, and real‐world data are lacking.
Shannon M. Vandriel +93 more
wiley +1 more source
Llorona de agua y duende de aire: el cronotopo en la narrativa plural de dos leyendas colombianas
Estudios de Literatura Colombiana, 2021 Este trabajo crítico analizará dos leyendas recogidas en el municipio de Susacón (Boyacá) a la luz del concepto de cronotopo desarrollado por Mijail Bajtín [1937], con el fin de develar algunos elementos simbólicos de la construcción cultural de lo ...
José Inocencio Becerra Lagos +1 more
doaj +1 more source