Results 41 to 50 of about 941,937 (358)

Mechanistic dissection of dominant AIRE mutations in mouse models reveals AIRE autoregulation

Journal of Experimental Medicine, 2021
Aire is a master of central tolerance. Goldfarb et al. compare mice with recessive or dominant-negative Aire patient mutations to dissect the mechanisms that underlie dominance and identify an autoregulatory mechanism by which Aire negatively modulates ...
Y. Goldfarb, Tal Givony, Noam Kadouri, J. Dobeš, Cristina Peligero-Cruz, Itay Zalayat, G. Damari, B. Dassa, S. Ben-Dor, Yael Gruper, B. Oftedal, E. Bratland, Martina M Erichsen, A. Berger, Ayelet Avin, Shir Nevo, U. Haljasorg, Y. Kuperman, Adi Ulman, R. Haffner-Krausz, Z. Porat, U. Atasoy, D. Leshkowitz, E. Husebye, J. Abramson   +24 more
semanticscholar   +1 more source

Aire Controls Heterogeneity of Medullary Thymic Epithelial Cells for the Expression of Self-Antigens

Journal of Immunology, 2021
Key Points Many Aire-dependent genes in mTECs, including TRAs, may not be Aire’s primary targets. Aire-dependent mTEC heterogeneity accounts for the altered gene expression in mTECs.
Hitoshi Nishijima, Minoru Matsumoto, J. Morimoto, K. Hosomichi, N. Akiyama, T. Akiyama, Takeshi Oya, Koichi Tsuneyama, H. Yoshida, M. Matsumoto   +9 more
semanticscholar   +1 more source

SĄNAUDŲ UŽ VANDENS PASLAUGAS SUSIGRĄŽINIMO PRINCIPAS

Teisė, 2016
Šiame straipsnyje analizuojama viena iš vandens išteklių apsaugos priemonių – sąnaudų už vandens paslaugas susigrąžinimo principas. Tiriama šio principo kilmė, funkcijos ir turinys.
Airė Keturakienė
doaj   +1 more source

Aire regulates chromatin looping by evicting CTCF from domain boundaries and favoring accumulation of cohesin on superenhancers

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Aire controls immunological tolerance by driving promiscuous expression of a large swath of the genome in medullary thymic epithelial cells (mTECs). Its molecular mechanism remains enigmatic.
K. Bansal, Daniel A. Michelson, Ricardo N. Ramirez, A. Viny, R. Levine, C. Benoist, D. Mathis   +6 more
semanticscholar   +1 more source

Altered expression of autoimmune regulator in infant down syndrome thymus, a possible contributor to an autoimmune phenotype. [PDF]

, 2014
To access publisher's full text version of this article click on the hyperlink at the bottom of the pageDown syndrome (DS), caused by trisomy of chromosome 21, is associated with immunological dysfunctions such as increased frequency of infections and ...
Annerén, Göran, Berglund, Martin, Ekwall, Olov, Gudmundsdottir, Judith, Gustafsson, Jan, Kämpe, Olle, Lindgren, Susanne, Lundberg, Vanja, Sandström, Kerstin, Skogberg, Gabriel, Sunnegårdh, Jan, Telemo, Esbjörn, van der Post, Sjoerd   +12 more
core   +1 more source

TEISĖ Į VANDENĮ

Teisė, 2017
Straipsnyje analizuojama teisė į vandenį, įforminusi prieigos prie geriamojo vandens kaip žmogaus teisės idėją. Tiriamas šios teisės pripažinimas ir apibrėžimas tarptautiniuose dokumentuose, jos reglamentavimo ir apsaugos modeliai nacionalinėse teisinėse
Airė Keturakienė
doaj   +1 more source

Contaminación atmosférica y aerobiología del casco urbano de Calceta-Manabí

La Técnica: Revista de las Agrociencias, 2020
Biostabilization of poultry excreta through efficient microorganisms for the control of environmental contamination En la ciudad de Calceta (Manabí, Ecuador) se han identificado tres granjas avícolas destinadas a la producción de huevos, las cuales no
Holanda Teresa Vivas Saltos, Laura Gema Mendoza Cedeño, Julio Abel Loureiro Salabarría, María Isabel Delgado Moreira, María Fernanda Pincay Cantos, Verónica Monserrate Vera Villamil   +5 more
doaj   +1 more source

AIRE in context: Leveraging chromatin plasticity to trigger ectopic gene expression *

Immunological Reviews, 2021
The emergence of antigen receptor diversity in clonotypic lymphocytes drove the evolution of a novel gene, Aire, that enabled the adaptive immune system to discriminate foreign invaders from self‐constituents.
Caroline Kaiser, Alexandra Bradu, Noah Gamble, Jason A Caldwell, Andrew S. Koh   +4 more
semanticscholar   +1 more source

The Role of AIRE Deficiency in Infertility and Its Potential Pathogenesis

Frontiers in Immunology, 2021
The increasing number of patients with infertility is recognized as an emerging problem worldwide. However, little is known about the cause of infertility. At present, it is believed that infertility may be related to genetic or abnormal immune responses.
Xue-Yang Zou, Yi Zhang, Xiaoya Wang, Rongchao Zhang, Wei Yang   +4 more
semanticscholar   +1 more source

Post-Aire Medullary Thymic Epithelial Cells and Hassall’s Corpuscles as Inducers of Tonic Pro-Inflammatory Microenvironment

Frontiers in Immunology, 2021
While there is convincing evidence on the role of Aire-positive medullary thymic epithelial cells (mTEC) in the induction of central tolerance, the nature and function of post-Aire mTECs and Hassall’s corpuscles have remained enigmatic. Here we summarize
M. Laan, Ahto Salumets, Annabelle Klein, Kerli Reintamm, Rudolf Bichele, Hedi Peterson, P. Peterson   +6 more
semanticscholar   +1 more source