Smoking is associated with shortened airway cilia. [PDF]
PLoS ONE, 2009 BACKGROUND:Whereas cilia damage and reduced cilia beat frequency have been implicated as causative of reduced mucociliary clearance in smokers, theoretically mucociliary clearance could also be affected by cilia length.
Philip L Leopold +5 more
doaj +1 more source
Materials Today Bio, 2023 Human lung function is intricately linked to blood flow and breathing cycles, but it remains unknown how these dynamic cues shape human airway epithelial biology.
Janna C. Nawroth +12 more
doaj +1 more source
Informing Selection of Nanomaterial Concentrations for ToxCast In Vitro Testing based on Occupational Exposure Potential [PDF]
, 2011 Background: Little justification is generally provided for selection of in vitro assay testing concentrations for engineered nanomaterials (ENMs). Selection of concentration levels for hazard evaluation based on real-world exposure scenarios is desirable.
Gangwal, Sumit +6 more
core +1 more source
A20 deficiency in lung epithelial cells protects against influenza A virus infection [PDF]
, 2016 A20 negatively regulates multiple inflammatory signalling pathways. We here addressed the role of A20 in club cells (also known as Clara cells) of the bronchial epithelium in their response to influenza A virus infection.
Beyaert, Rudi +12 more
core +8 more sources
The regulation of host defences to infection by the microbiota [PDF]
, 2016 The skin and mucosal epithelia of humans and other mammals are permanently colonised by large microbial communities (the microbiota). Due to this life-long association with the microbiota, these microbes have an extensive influence over the physiology of
Brown, RL, Clarke, TB
core +1 more source
Vascular Growth in the Fetal Lung [PDF]
, 2011 The structure of the lung is truly remarkable. It is primarily composed of three branched tubular networks (the airway, pulmonary artery and vein, bronchial artery and vein) which supply blood and air to the site of gas exchange and which maintain ...
Land, Stephen
core +4 more sources
In vivo Neutralization of Pro-inflammatory Cytokines During Secondary Streptococcus pneumoniae Infection Post Influenza A Virus Infection [PDF]
, 2019 An overt pro-inflammatory immune response is a key factor contributing to lethal pneumococcal infection in an influenza pre-infected host and represents a potential target for therapeutic intervention.
Boehme, Julia D. +8 more
core +1 more source
BMC Health Services Research, 2019 Background Consumers frequently access the internet looking for health information. With the growing burden of chronic disease internationally, strategies are focussing on self-management interventions in community and ambulatory settings.
Laura Cooper +2 more
doaj +1 more source
Nanoparticle-Mediated Strategies for Enhanced Drug Penetration and Retention in the Airway Mucosa
Pharmaceutics, 2023 Airway mucus is a complex viscoelastic gel composed mainly of water, glycoproteins, lipids, enzymes, minerals, etc. Among them, glycoproteins are the main factors determining mucus’s gel-like rheology. Airway mucus forms a protective barrier by secreting
Xin Yan, Xianyi Sha
doaj +1 more source
In vivo therapeutic efficacy of frog skin-derived peptides against Pseudomonas aeruginosa-induced pulmonary infection [PDF]
, 2017 Pseudomonas aeruginosa is an opportunistic and frequently drug-resistant pulmonary pathogen especially in cystic fibrosis sufferers. Recently, the frog skin-derived antimicrobial peptide (AMP) Esc(1-21) and its diastereomer Esc(1-21)-1c were found to ...
Chen, Chen +2 more
core +1 more source