Results 161 to 170 of about 1,027,405 (258)

Learning beyond the lab: A gamified approach to anatomy education in a museum‐based experience

Anatomical Sciences Education, EarlyView.
Abstract Anatomy education, traditionally rooted in descriptive instruction and cadaveric dissection, is undergoing a significant transformation through the integration of educational technologies and contemporary pedagogical strategies. Among these, active learning methodologies, such as gamified‐based learning, have emerged as approaches designed to ...
Wendell Nunes da Silva, Diego Pulzatto Cury, Silvia Lacchini, Ana Paula Cremasco Takano   +3 more
wiley   +1 more source

The effectiveness of cyproheptadine as a treatment option for cats with eosinophilic airway inflammation. [PDF]

Vet Evid
Seeman J, Kreisler R, Norris J.
europepmc   +1 more source

Twenty years of inhaler therapy: A nationwide drug utilization study

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to map nationwide trends and prescribing patterns in inhaler use from 2004 to 2023. In light of evolving clinical guidelines and attention to the environmental impact of inhalers within recent years, we also examined variation in prescribing behaviour and patient‐level treatment choices. Methods Using nationwide health registries,
Katrine Bitsch Johansen, Lars Christian Lund, Zandra Nymand Ennis, Andrew Scourfield, Anders Løkke, Sidsel Arnspang Pedersen   +5 more
wiley   +1 more source

Effect of Dupilumab on Airway Inflammation in Patients With Persistent Asthma. [PDF]

Allergy
Wechsler ME, Wenzel SE, Groshong SD, Castro M, Pavord ID, Rabe KF, Laws E, Jagerschmidt A, Gayvert K, Harel S, Hamilton JD, Amin N, Zhang L, Xing H, Elfakir A, Coulibaly B, Naimi S, Hamon S, Rowe PJ, Nestle F, Cunoosamy DM, de Rinaldis E, Mannent LP.   +22 more
europepmc   +1 more source

Histamine and the mechanisms of nausea and vomiting: Translating the uncertain pharmacology of cyclizine

British Journal of Clinical Pharmacology, EarlyView.
Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley   +1 more source

[Corrigendum] EBM84 attenuates airway inflammation and mucus hypersecretion in an ovalbumin‑induced murine model of asthma. [PDF]

Int J Mol Med
Shin IS, Lee MY, Jeon WY, Shin NR, Seo CS, Ha H.   +5 more
europepmc   +1 more source

Absorption, distribution, metabolism and excretion of londamocitinib after single‐dose inhaled, intravenous and oral administration in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim Londamocitinib (AZD4604) is an inhaled, selective Janus kinase 1 (JAK1) inhibitor in development for asthma. This open‐label, two‐part, phase I clinical study (NCT06157255) used a radiolabelled microtracer approach to evaluate the absolute bioavailability and the absorption, distribution, metabolism and excretion (ADME) of inhaled londamocitinib ...
Camille Riff, Peter Bold, Maria Heijer, Ryan A. Bragg, Danielle Steele, Tina Jellesmark Jensen, Davinder P. S. Dosanjh, Sabrina I. Hanswijk‐Bartelds, Esther van Duijn, Elwin R. Verheij, Somasekhara Menakuru, Rod Hughes, Helena Dahlbäck   +12 more
wiley   +1 more source

α4 Nicotinic Acetylcholine Receptor Signaling Exacerbates Type 2 Airway Inflammation. [PDF]

Allergy
Le NKT, Kanda A, Kamioka Y, Tokuhiro K, Kobayashi Y, Yun Y, Bui DV, Nguyen LM, Khuc LTT, Ho QD, Shimamura A, Suzuki K, Mitani A, Fukui K, Kawachi R, Morita M, Iwai H, Dombrowicz D, Yagi M.   +18 more
europepmc   +1 more source

Safety and pharmacokinetics of inhaled aloxistatin: A first‐in‐human phase 1 dose escalation trial

British Journal of Clinical Pharmacology, EarlyView.
Aims Aloxistatin (E64d) is a membrane‐permeable cysteine protease inhibitor prodrug that is converted by esterases to the active metabolite E64c (loxistatin). This first‐in‐human study evaluated the safety, tolerability and pharmacokinetics of single ascending doses of inhaled E64d in healthy volunteers.
Sebastian Fähndrich, Franziska Friedrich, Daniel Soriano, Jona Gjeloshi, Björn C. Frye, Xuan Phuoc Nguyen, Lydia Herbstritt, Caroline von Spee‐Mayer, Britta Lang, Fabrice Nollevaux, Andreas Hoheisel, Dorothee Winterberg, Armin Braun, Thomas Epting, Christine Contini, Karl Winkler, Thomas Reinheckel, Franziska C. Trudzinski, Gernot Rohde, Daiana Stolz, Robert Bals, Martin J. Hug, Sebastian Wirtz, Christoph Peters, Carolin Jenkner   +24 more
wiley   +1 more source

Airway inflammation and asthma control in patients using salbutamol or budesonide/formoterol reliever: a randomised, controlled study. [PDF]

ERJ Open Res
Martin MJ, Pavord ID, Chalmers JD, Saralaya D, Roy KG, Patel M, Clarke GW, Belton L, Rutgersson A, Gustafson P, Raja Gopal V, Harrison T.   +11 more
europepmc   +1 more source