Results 151 to 160 of about 1,027,405 (258)

Biomechanical strain patterns in Meckel's cartilage underlie mandibular variation in FGFR2 mouse models

The Anatomical Record, EarlyView.
Abstract Sequence variations in fibroblast growth factor receptor 2 (FGFR2) are associated with craniosynostosis syndromes, disrupting craniofacial development, yet early mandibular alterations remain poorly characterized. This study examined Meckel's cartilage (MC) and mandibular morphology in mouse models of Apert (Fgfr2+/P253R) and Crouzon ...
Fred R. Foster, Alexandre Freire, Ana Cláudia Rossi, Jordan Wilson, Joan T. Richtsmeier, Kazuhiko Kawasaki, Felippe B. Prado, Susan M. Motch Perrine   +7 more
wiley   +1 more source

Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing

Animal Research and One Health, EarlyView.
Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley   +1 more source

Early Growth Response 1-Associated Epithelial Autophagy-Related Changes in Allergic Airway Inflammation. [PDF]

Pediatr Discov
Wang X, Ren J, Zhao Y, Luo Z.
europepmc   +1 more source

Comparative Transcriptional Profiling of Key Macrophage and Fibroblast Subpopulations in Rheumatoid Arthritis–Associated Lung Disease

Arthritis &Rheumatology, EarlyView.
Objective Rheumatoid arthritis (RA) often involves extra‐articular complications, including interstitial lung disease (ILD) and/or pulmonary nodules. Transcriptomic profiling of lung tissue provides the opportunity to directly assess cell‐specific gene expression and corresponding pathway activation in different types of rheumatoid lung disease ...
Tracy Tabib, Ogechukwu Ezenwa, Joshua Sciurba, Eleanor B. Valenzi, John Sembrat, Brittany Cody, Jishnu Das, Robert Lafyatis, Dana P. Ascherman   +8 more
wiley   +1 more source

Anti-Nectin4 monoclonal antibodies attenuate airway inflammation and epithelial barrier dysfunction in asthma. [PDF]

Front Pharmacol
Lee PH, An M, Yoon S, Jang AS.
europepmc   +1 more source

Cation Enrichment and Hypersialylation in Chronic Rhinosinusitis Mucus

International Forum of Allergy &Rhinology, EarlyView.
Amanda M. Wood, Rachel E. Detwiler, McKenna Coughlin, Chelsea E. Pollard, Jeremiah A. Alt, Abigail Pulsipher, Jessica Kramer Stratton   +6 more
wiley   +1 more source

Plasma Proteome Reflects Tissue Damage and Clinical Manifestations in Patients With Inflammatory Myopathies

Arthritis &Rheumatology, EarlyView.
Objective Tissue‐specific biomarkers that are reliable and associated with clinical manifestations of idiopathic inflammatory myopathy (IIM) are lacking. The blood circulation in individuals serves as a central conduit, allowing communication between tissues and facilitating clearance and recycling of tissue‐derived proteins.
Yue‐Bei Luo, Josefin Kenrick, Angeles S. Galindo‐Feria, Antonella Notarnicola, Ana Daniela Ulloa Navas, Irene Peralta‐Garcia, Orane Demuynck, Andrea Kemp, Valérie Leclair, Karin Lodin, Eveline Van Gompel, Lara Dani, Fabricio Espinosa‐Ortega, Maryam Dastmalchi, Leonid Padyukov, Charlotta Preger, María Bueno Álvez, Mathias Uhlén, Peter Nilsson, Fredrik Edfors, Lina‐Marcela Diaz‐Gallo, Elisa Pin, Ingrid E. Lundberg, Begum Horuluoglu   +23 more
wiley   +1 more source

Glycerine drives acute lung-function impairment and airway inflammation after e-cigarette aerosol exposure in mice. [PDF]

Exp Physiol
Larcombe AN, Janka MA, Berry LJ, Mullins BJ.   +3 more
europepmc   +1 more source

The dead still teach the living: Body donor dissection in the digital age of anatomy education

Anatomical Sciences Education, EarlyView.
Abstract Donor‐based dissection has become increasingly contested in modern medical curricula as digital anatomy platforms, simulation technologies, virtual dissection tables, three‐dimensional reconstructions, and artificial intelligence‐supported learning have expanded.
Uğur Baran Kasırga
wiley   +1 more source

Non-type 2 airway inflammation in severe asthma: from bench to bedside. [PDF]

Front Immunol
Tashiro H, Kuwahara Y, Kurihara Y, Takahashi K.   +3 more
europepmc   +1 more source