Results 181 to 190 of about 959,395 (302)

Anatomy of the Soft Palate and Its Role in Upper Airway Function: A Narrative Review

Clinical Anatomy, EarlyView.
ABSTRACT The soft palate is a complex anatomical structure, located at the posterior aspect of the oral and nasal cavities, able to dynamically create valve closure of the nasal and the oral cavities. Its precise movement is critical for speech, swallowing, and respiration. Despite its functional importance, detailed characterization of its constituent
James C. D. Miller, Nikki Mills, Ho‐Fung Chan, Alys R. Clark, S. Ali Mirjalili   +4 more
wiley   +1 more source

From Airway Inflammation to Molecular Remodeling: Integrating YKL-40, MBL and Epigenetic Biomarkers in Asthma and COPD. [PDF]

Biomolecules
Borta SM, Crișan AS, Popețiu RO, Vulciu PA, Știrbu O, Avram CR, Goldiș D, Rus LA, Roman DR, Chioreanu A, Bugari RA, Zdremțan D, Firu CG, Donath-Miklos I.   +13 more
europepmc   +1 more source

Non‐Invasive Estimation of Systemic Drug Exposure Using Exhaled Breath Metabolomics in Humans: A Translational Proof‐of‐Concept Study

Clinical Pharmacology &Therapeutics, EarlyView.
Accurate assessment of systemic drug exposure in humans remains challenging, as conventional approaches rely on intermittent blood sampling and laboratory‐based assays that are invasive and provide limited temporal resolution. Exhaled breath contains volatile and semi‐volatile compounds arising from drug metabolism and downstream biological processes ...
Kai Fricke, Diego M. Baur, Kapil Dev Singh, Felix Schmidt, Kathrin Müsch, Noriane A. Sievi, Marco Di Donato, Anton Schmick, Jonas Herth, Silvia Ulrich, Pablo Sinues, Marian Galovic, Malcolm Kohler   +12 more
wiley   +1 more source

Cannabichromeorcin targets cathepsin L to alleviate oxidative stress-Driven airway inflammation in severe asthma. [PDF]

Redox Biol
Huang J, Chen Y, Deng Y, Hu D, Chen Y, Li Y, Xie C, Fan K, Zhu B, Gong Z, Yang J, Huang S, Peng X, Peng X, Huang B, Zhao W, Du Q, Zhao H.   +17 more
europepmc   +1 more source

Advances in New Approach Methodologies at FDA's Division of Applied Regulatory Science

Clinical Pharmacology &Therapeutics, EarlyView.
New Approach Methodologies (NAMs) represent a paradigm shift in drug development and regulatory science, offering human‐relevant alternatives to traditional preclinical models. This mini‐review highlights recent advances in NAM development, validation, and regulatory application from FDA's Division of Applied Regulatory Science (DARS).
Ksenia Blinova, Kimberly Chiu, Anik Chaturbedi, Jahan Cooper, Tromondae K. Feaster, Paula L. Hyland, Lidiya Stavitskaya, Wendy W. Wu, Jeffry Florian, Rodney Rouse   +9 more
wiley   +1 more source

Correction: The OX40-OX40L Co-Stimulatory Pathway as a Shared Driver of Immune Persistence in Skin and Airway Inflammation. [PDF]

Clin Rev Allergy Immunol
Navarro-Triviño FJ, Torres T, Ruiz-Villaverde R, Moreno-Amador JL, Mendes-Bastos P.   +4 more
europepmc   +1 more source

Intestinal Epithelial Memory: From Inflammatory Imprinting to Metabolite‐Shaped Immune Tolerance

Barrier Immunity, EarlyView.
ABSTRACT Intestinal epithelial cells are rapidly renewing barrier cells that maintain compartmentalization between the luminal environment and the mucosal immune system through epithelial transport, antimicrobial defense, secretory programs, and cytokine‐mediated communication.
Wenjing Yang, Tianming Yu, Yingzi Cong
wiley   +1 more source

FGF7 mitigates airway inflammation and epithelial injury in cigarette smoke-induced COPD model. [PDF]

Front Immunol
Gong X, Li J, Wang H, Luo X, Hu X, Shen J, Jia W, Wan Q, Caikai S, Guo Z, Yan F, Zhang Y, Sun F, Xu S.   +13 more
europepmc   +1 more source

Population Pharmacokinetics and Detection Times of Betamethasone After Intravenous, Intramuscular, and Intranasal Jet Administration of Betamethasone Sodium Phosphate in Horses

Drug Testing and Analysis, EarlyView.
Betamethasone concentrations in 20 horses from Japan and Germany following IV, IM, and INJ administration of betamethasone phosphate were analyzed using population pharmacokinetic modeling. For IV administration of 0.04 mg/kg q24 h, IPC and IUC were 0.012 and 0.31 ng/mL, respectively; the IUC approximated the IFHA urine ISL (0.20 ng/mL).
Taisuke Kuroda, Marc Machnik, Mario Thevis, Yohei Minamijima, Gary Ngai‐Wa Leung, Motoi Nomura, Fumiaki Mizobe, Yuhiro Ishikawa, Kazuhiro Kamiya, Pierre‐Louis Toutain   +9 more
wiley   +1 more source

The Impact of Obesity on Airway Inflammation, Lung Function and Biologic Treatment in Asthma: A Narrative Review. [PDF]

J Inflamm Res
Hadžić B, Vasbinder EC, Lek RM, Castro Cabezas M, Braunstahl GJ.   +4 more
europepmc   +1 more source