Results 221 to 230 of about 271,362 (308)

Itaconate Modulates Neutrophil Homeostasis to Ameliorate Airway Inflammation in Diesel Exhaust Particles-exacerbated Asthma via Inhibiting NETs Formation. [PDF]

Int J Biol Sci
Zhu G, Ye L, Song Y, Chen Y, Cai H, Abuduxukuer Z, Zhu L, Zeng Y, Zhu W, Ye D, Song Y, Wang P, Jin M, Wang J.   +13 more
europepmc   +1 more source

The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets

iNew Medicine, EarlyView.
The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong, Zhenyu Wang, Suyin Yang, Kaige Gao, Xin Yang, Min Tang   +5 more
wiley   +1 more source

Proteomic Analysis of Asthma Airway Inflammation after Allergen Challenge: A Heterogeneous Response. [PDF]

Am J Respir Crit Care Med
Johansson MW, Esnault S, Millikin RJ, Steill JW, Lee KE, Floerke HL, Denlinger LC, Stewart R, Jarjour NN, Tattersall MC.   +9 more
europepmc   +1 more source

Occupational Exposure to Factory‐Derived Particulate Matter 2.5 Induces Cutaneous Toxicity in Workers and HaCaT Keratinocytes Through Oxidative Stress and Inflammation

Journal of Applied Toxicology, EarlyView.
ABSTRACT This study aimed to evaluate the toxicological effects of occupational exposure to factory‐derived particulate matter (PM2.5) on human skin, emphasizing its role as a potential target organ of environmental toxicants. An epidemiological survey comparing factory and nonfactory workers was conducted by assessing their skin elasticity and color ...
Miku Tanaka, Masayuki Takaishi, Iroha Okuda, Toshiki Fujimoto, Mayumi Tsuji, Yuri Okano, Yasuhiro Ishihara, Maori Kono   +7 more
wiley   +1 more source

Cold temperature enhances innate eosinophilic airway inflammation via transient receptor potential ankyrin1. [PDF]

Front Immunol
Dotake Y, Matsuyama T, Machida K, Matsuyama H, Takagi K, Mizuno K, Kan-O K, Kuwaki T, Inoue H, Tanaka K.   +9 more
europepmc   +1 more source

New Approach Methodologies (NAMs) in Alternative Methods: A Comparative Cytotoxicity Analysis of Nanostructured Hydroxyapatite in Adipose Stem Cells Spheroids

Journal of Applied Toxicology, EarlyView.
ABSTRACT Toxicological assessment is essential in NP approval for health and medical applications. Although 2D cell culture has been widely used, 3D models, especially spheroids, provide better predictive value for toxicological risk assessments since they replicate complex cellular interactions more accurately.
Bianca Montenegro, Rosângela Mayer Gonçalves, Marcelle Gomes Pegurier, Isabelle Amorim, Alexandre Malta Rossi, Leandra Santos Baptista   +5 more
wiley   +1 more source

Mixed granulocytic airway inflammation impairs aversive learning and alters neuroimmune biomarkers in mice. [PDF]

Sci Rep
Morera PMA, Beserra-Filho JIA, Soares-Silva B, Lambertucci RH, de Queiroz VC, Pinheiro-Menegasso NM, da Silva RC, Ponci V, Oliveira MA, Tavares-de-Lima W, Lago JHG, Ribeiro AM, Prado CM.   +12 more
europepmc   +1 more source

A Novel Air‐Liquid Interface Exposure System for Continuous Gas Exposure of Airway Epithelial Cells: Exposure of NO2 With Viral Co‐Challenge

Journal of Applied Toxicology, EarlyView.
ABSTRACT Most in vitro toxicological research investigating the effects of inhaled compounds employ short‐term exposures of a couple of hours, or repeated, intermittent exposures for a limited number of days with exposure free periods, whereas in reality, we are continuously exposed, albeit to variable concentrations.
Marcia M. Oldenburger, Evert Duistermaat, Pieter S. Hiemstra, Flemming R. Cassee, Yvonne C. M. Staal   +4 more
wiley   +1 more source

Der p 23, A Frequent IgE Sensitizer in Humans, Induces Airway Inflammation in Mice. [PDF]

Int J Mol Sci
Donado K, Durango L, Benedetti I, Todorovic N, Regino R, Lozano A, Marrugo V, Reina R, Mercado D, Acevedo N, Zakzuk J, Fernández-Caldas E, Keller W, Puerta L, Caraballo L.   +14 more
europepmc   +1 more source

Ivermectin Toxicity in Humans and Animals: Clinical Spectrum, Mechanisms, and Management

Journal of Applied Toxicology, EarlyView.
ABSTRACT Ivermectin is a widely used macrocyclic lactone with established efficacy against a broad range of parasitic infections in humans and animals and a long‐standing reputation for clinical safety. However, increasing evidence indicates that ivermectin can produce clinically relevant toxicity under specific conditions, particularly involving the ...
Serkan Yilmaz, Bayram Göktaş, İlker Ateş, Mustafa Çelik   +3 more
wiley   +1 more source