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Neurogenic inflammation in the airways
Respiration Physiology, 2001Release of neuropeptides, including tachykinins and calcitonin gene-related peptide, from sensory nerves via an axon or local reflex may have inflammatory effects in the airways. This neurogenic inflammation may be initiated by activation of sensory nerves by inflammatory mediators and irritants. Neurogenic inflammation is well developed in rodents and
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Neurogenic Inflammation in Airways
International Archives of Allergy and Applied Immunology, 2009Neurogenic inflammation, due to release of neuropeptides from sensory nerves, has been demonstrated in airways of several species, particularly rodents, and may contribute to the inflammatory response in asthmatic airways. Tachykinins (substance P and neurokinin A) and calcitonin-gene-related peptide released from airway sensory nerves may cause ...
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Purinergic Regulation of Airway Inflammation
2011The immune and inflammatory responses initiated by the interaction of a pathogen with airway surfaces constitute vital mechanisms to eradicate an infection. Sentinel dendritic cells embedded in the mucosa migrate to the lymph nodes to induce immune responses, whereas epithelial cells release chemokines to recruit inflammatory cells engaged in the ...
M. KOEPPEN +3 more
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Airway fibrosis in a mouse model of airway inflammation
Toxicology and Applied Pharmacology, 2003BALB/c mice were sensitized to ovalbumin by systemic injection and then exposed for up to 8 weeks to ovalbumin aerosols in whole body chambers. A pattern of airway inflammation, mucous cell hypertrophy and hyperplasia, and airway remodeling with submucosal fibrosis was observed as lesions evolved over time.
Nicholas J, Kenyon +2 more
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The Effects of Theophylline on Airway Inflammation
Chest, 1987One of the important modes of action of theophylline in asthma and chronic obstructive airway disease may be the inhibition of airway inflammation. This hypothesis is based on in vitro and in vivo studies demonstrating that theophylline at therapeutic concentrations has an inhibitory activity on airway inflammation induced by allergic and nonallergic ...
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Adiposity, asthma, and airway inflammation
Journal of Allergy and Clinical Immunology, 2007Several studies have found obesity to be associated with an increased prevalence of asthma. For reasons that remain unclear, this association has often been reported to be stronger in women than in men. One possible explanation might be that these studies have used body mass index to identify adiposity, which might be a less reliable measure of body ...
Christene R, McLachlan +10 more
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Posttranscriptional control of airway inflammation
WIREs RNA, 2017Acute inflammation in the lungs is a vital protective response, efficiently and swiftly eliminating inciters of tissue injury. However, in respiratory diseases characterized by chronic inflammation, such as chronic obstructive pulmonary disease and asthma, enhanced expression of inflammatory mediators leads to tissue damage and impaired lung function ...
Wendy, Ezegbunam, Robert, Foronjy
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Airway inflammation in children with tracheostomy
Pediatric Pulmonology, 2004AbstractWe hypothesised that long‐term tracheostomy in infants and children may perpetuate chronic airway inflammation and airway remodeling due to easier access to the lungs for microorganisms. Pulmonary surfactant represents an important part of the initial host defense, and in particular, the surfactant proteins (SP) A and D may directly interact ...
M, Griese +7 more
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Macrolides and airway inflammation in children
Paediatric Respiratory Reviews, 2005For more than 20 years macrolide antibiotics have been used to treat chronic inflammatory airway diseases based on their immunomodulatory activity. Macrolide antibiotics down-regulate damaging prolonged inflammation as well as increase mucus clearance, decrease bacterial virulence and prevent biofilm formation. Initially shown to decrease morbidity and
Masaharu, Shinkai, Bruce K, Rubin
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Airway inflammation and remodeling in asthma
Current Opinion in Pulmonary Medicine, 2000An important advance in our understanding of the pathophysiology of asthma has been the discovery that airway inflammation is not confined to severe asthma but also characterizes mild and moderate asthma. Inflammation in asthma may be the result of a peculiar type of lymphocytic inflammation whereby Th2 lymphocytes secrete cytokines that orchestrate ...
J V, Fahy, D B, Corry, H A, Boushey
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