Results 41 to 50 of about 168 (162)
Pediatric Upper Airway Obstruction
DeckerMed Pediatrics Weekly Curriculum™, 2018 Upper airway obstruction is a common reason that children present for emergency care, and causes range from simple and benign etiologies to life-threatening conditions requiring emergent intervention. Both congenital and acquired conditions can result in airway obstruction at various levels, and due to the high risk of acute decompensation associated ...
Suzanne M. Schmidt, Michael W. Chan
openaire +2 more sources
Arthritis &Rheumatology, EarlyView.Objective The sparse effector “omnigenic” hypothesis postulates that the polygenic effects of common single nucleotide polymorphisms (SNPs) on a typical complex trait are mediated by trans effects that coalesce on expression of a relatively sparse set of core genes.
Athina Spiliopoulou +9 more
wiley +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT The rise in chronic lung diseases globally and the corresponding lag in drug discovery in this field highlights the need for In Vitro models closely mimicking In Vivo lung tissue. Efforts to date have largely focused on In Vitro coculture models, often neglecting the pulmonary vasculature's role in lung physiology and lacking perfusability. To
Sakshi Phogat +3 more
wiley +1 more source
Promising Prodiginins Biological Activities
Chemistry &Biodiversity, EarlyView.ABSTRACT Prodiginins are a large family of at least 34 pyrrolic compounds, including the well‐studied red pigment prodigiosin. Prodiginins are produced by several microorganisms displaying broad biological activities, including antimicrobial, antiviral, antiparasitic, antiproliferative, and immunosuppressive activities.
María F. Ladetto +6 more
wiley +1 more source
From Allergy to Angina: A Unique Presentation of Kounis Syndrome
Catheterization and Cardiovascular Interventions, EarlyView.ABSTRACT Kounis syndrome (KS) is a rare condition characterized by acute coronary syndrome (ACS) triggered by an allergic reaction. This report presents a case of high‐risk ACS associated with a food allergy. A 53‐year‐old male with no prior medical history presented to the emergency department with itching, facial swelling, chest tightness, shortness ...
Momen Ali +3 more
wiley +1 more source
Recent Cutting‐Edge Technologies for the Delivery of Peptide Nucleic Acid
Chemistry – A European Journal, EarlyView.This review provides an overview of PNA cellular delivery methods, starting with traditional peptide‐based systems and progressing to advanced approaches using nanoparticles, liposomes, and calixarene. It highlights how these innovative strategies have opened the way for more effective and efficient PNA delivery, ultimately enhancing the potential for ...
Concetta Avitabile +4 more
wiley +1 more source
Clinical Pharmacology in Drug Development, EarlyView.Abstract RBN‐3143 is an inhibitor of PARP14 in development for inflammatory diseases. Multiple assessments were conducted to evaluate the clinical pharmacology properties of RBN‐3134. A randomized, double‐blind, placebo‐controlled study assigned healthy volunteers (HVs) to single ascending doses (SADs) (25‐1000 mg) or multiple ascending doses (MADs ...
Thomas M. Polasek +9 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Pemetrexed is a cornerstone in chemo(immunotherapy) of non‐small cell lung cancer and mesothelioma; however, it is contraindicated in patients with renal impairment due to severe toxicity concerns. Therefore, a large proportion of patients is withheld from effective chemo(immunotherapy).
Nikki de Rouw +18 more
wiley +1 more source