Results 251 to 260 of about 365,854 (289)

Airway remodeling in asthma

Current Opinion in Pulmonary Medicine, 2005
This overview summarizes some the more recent studies of remodeling in patients with asthma, studies using animal models to study the interaction of cell types and mediators, and studies using in vitro models to assess the effects of mitogenic stimuli, including mechanical strain, on mesenchymal cells and extracellular matrix proteins.
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Role of airway smooth muscle in airway remodeling

Journal of Allergy and Clinical Immunology, 2005
Editor’s note: This feature, Images in allergy and immunology, is designed to highlight current concepts of the immunopathology of allergic diseases and other common immunologically mediated diseases. The presentation will appear as sets of images that involve cross-pathology, histopathology, and molecular pathology and will cover a range of topics of ...
Philippe, Joubert, Qutayba, Hamid
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Fibrosis and airway remodelling

Clinical & Experimental Allergy, 2000
The term ‘airway remodelling’ is now widely used to refer to the development of specific structural changes in the airway wall in asthma. Particular interest has focused on subepithelial fibrosis, myofibroblast accumulation, airway smooth muscle hyperplasia and hypertrophy, mucous gland and goblet cell hyperplasia, and epithelial disruption.
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Airway remodeling and persistent airway obstruction in asthma

Journal of Allergy and Clinical Immunology, 1999
There is growing recognition that some patients with long-standing asthma may possess a component of irreversible airflow obstruction despite optimal therapy. This persistent airflow obstruction is thought to be the result of structural changes in the airways that occur as a result of airway remodeling.
J E, Fish, S P, Peters
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Airway inflammation and remodeling in asthma

Current Opinion in Pulmonary Medicine, 2000
An important advance in our understanding of the pathophysiology of asthma has been the discovery that airway inflammation is not confined to severe asthma but also characterizes mild and moderate asthma. Inflammation in asthma may be the result of a peculiar type of lymphocytic inflammation whereby Th2 lymphocytes secrete cytokines that orchestrate ...
J V, Fahy, D B, Corry, H A, Boushey
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Airway vascular remodeling in asthma

Current Allergy and Asthma Reports, 2003
Several characteristic changes occur in the bronchial wall in asthma, including specific changes to the vasculature. These result in an increase in vessel numbers per unit area, as well as increased vessel activity suggested by vasodilatation, vessel leakage, and cellular margination with transmigration to target tissues. This combined action in asthma
John W, Wilson, Tom, Kotsimbos
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Mechanical Stimuli to Airway Remodeling

American Journal of Respiratory and Critical Care Medicine, 2001
Abstract The airway is exposed to a variety of mechanical stimuli, the most prominent of which is the acute compressive stress caused by bronchoconstriction. The folding of the airway wall into a rosette pattern during bronchoconstriction creates a complex stress field, with the highest stresses compressing the epithelial layer at the
D J, Tschumperlin, J M, Drazen
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Airway remodelling in the transplanted lung

Cell and Tissue Research, 2016
Following lung transplantation, fibrotic remodelling of the small airways has been recognized for almost 5 decades as the main correlate of chronic graft failure and a major obstacle to long-term survival. Mainly due to airway fibrosis, pulmonary allografts currently show the highest attrition rate of all solid organ transplants, with a 5-year survival
Mark, Kuehnel, Lavinia, Maegel, Jens, Vogel-Claussen, Jan Lukas, Robertus, Danny, Jonigk   +4 more
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The Role of Leukotrienes in Airway Remodeling

Current Molecular Medicine, 2009
Asthma is an inflammatory disorder of the airways that has been typified by its bronchospastic component. New attention has been directed to the long-term changes in asthmatic airways as indicated by the accelerated rate of lung function decline occurring in these patients despite therapy with inhaled corticosteroids.
Anjuli K, Mehrotra, William R, Henderson
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Remodeling of asthmatic airways by glucocorticosteroids

Journal of Allergy and Clinical Immunology, 1996
Airway epithelial damage and chronic inflammation are the main contributory factors in the development of asthma. Until bronchoscopic techniques were developed, clear evidence of the inflammation was relatively unknown. Today, with electron microscopy of bronchial biopsy specimens or immunohistochemistry studies, a definitive picture emerges of the ...
L A, Laitinen, A, Laitinen
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