Results 251 to 260 of about 45,718 (290)

Mechanisms of Airway Remodeling

Chest, 2013
Airway remodeling comprises the structural changes of airway walls, induced by repeated injury and repair processes. It is characterized by the changes of tissue, cellular, and molecular composition, affecting airway smooth muscle, epithelium, blood vessels, and extracellular matrix.
Nobuaki, Hirota, James G, Martin
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Autophagy plays a role in FSTL1-induced epithelial mesenchymal transition and airway remodeling in asthma

American Journal of Physiology - Lung Cellular and Molecular Physiology, 2017
Asthma is a chronic disease related to airway hyperresponsiveness and airway remodeling. Airway remodeling is the important reason of refractory asthma and is associated with differentiation of airway epithelia into myofibroblasts via epithelial ...
Marina Miller, Jinxiang Wu, Jiawei Xu
exaly   +2 more sources

Airway remodeling in the pathogenesis of asthma

Current Allergy and Asthma Reports, 2001
The inflammatory and remodelling processes that underlie asthma result from a highly complex interaction between various cell types. Apart from inflammatory cells, such as eosinophils, activated T cells, mast cells and macrophages, structural tissue cells such as epithelial cells, fibroblasts and smooth muscle cells can also play an important effector ...
Vignola AM, Gagliardo R, Siena A, Chiappara G, Bonsignore MR, Bousquet J, Bonsignore G   +6 more
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Airway remodeling in asthma

Current Opinion in Pulmonary Medicine, 2005
This overview summarizes some the more recent studies of remodeling in patients with asthma, studies using animal models to study the interaction of cell types and mediators, and studies using in vitro models to assess the effects of mitogenic stimuli, including mechanical strain, on mesenchymal cells and extracellular matrix proteins.
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Fibrosis and airway remodelling

Clinical & Experimental Allergy, 2000
The term ‘airway remodelling’ is now widely used to refer to the development of specific structural changes in the airway wall in asthma. Particular interest has focused on subepithelial fibrosis, myofibroblast accumulation, airway smooth muscle hyperplasia and hypertrophy, mucous gland and goblet cell hyperplasia, and epithelial disruption.
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Role of airway smooth muscle in airway remodeling

Journal of Allergy and Clinical Immunology, 2005
Editor’s note: This feature, Images in allergy and immunology, is designed to highlight current concepts of the immunopathology of allergic diseases and other common immunologically mediated diseases. The presentation will appear as sets of images that involve cross-pathology, histopathology, and molecular pathology and will cover a range of topics of ...
Philippe, Joubert, Qutayba, Hamid
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Airway remodeling and persistent airway obstruction in asthma

Journal of Allergy and Clinical Immunology, 1999
There is growing recognition that some patients with long-standing asthma may possess a component of irreversible airflow obstruction despite optimal therapy. This persistent airflow obstruction is thought to be the result of structural changes in the airways that occur as a result of airway remodeling.
J E, Fish, S P, Peters
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Airway inflammation and remodeling in asthma

Current Opinion in Pulmonary Medicine, 2000
An important advance in our understanding of the pathophysiology of asthma has been the discovery that airway inflammation is not confined to severe asthma but also characterizes mild and moderate asthma. Inflammation in asthma may be the result of a peculiar type of lymphocytic inflammation whereby Th2 lymphocytes secrete cytokines that orchestrate ...
J V, Fahy, D B, Corry, H A, Boushey
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Mechanical Stimuli to Airway Remodeling

American Journal of Respiratory and Critical Care Medicine, 2001
Abstract The airway is exposed to a variety of mechanical stimuli, the most prominent of which is the acute compressive stress caused by bronchoconstriction. The folding of the airway wall into a rosette pattern during bronchoconstriction creates a complex stress field, with the highest stresses compressing the epithelial layer at the
D J, Tschumperlin, J M, Drazen
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Airway vascular remodeling in asthma

Current Allergy and Asthma Reports, 2003
Several characteristic changes occur in the bronchial wall in asthma, including specific changes to the vasculature. These result in an increase in vessel numbers per unit area, as well as increased vessel activity suggested by vasodilatation, vessel leakage, and cellular margination with transmigration to target tissues. This combined action in asthma
John W, Wilson, Tom, Kotsimbos
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