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Asthma therapy and airway remodeling
Journal of Allergy and Clinical Immunology, 2007Asthma is characterized by variable degrees of chronic inflammation and structural alterations in the airways. The most prominent abnormalities include epithelial denudation, goblet cell metaplasia, subepithelial thickening, increased airway smooth muscle mass, bronchial gland enlargement, angiogenesis, and alterations in extracellular matrix ...
Thais, Mauad +2 more
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Role of airway smooth muscle in airway remodeling
Journal of Allergy and Clinical Immunology, 2005Editor’s note: This feature, Images in allergy and immunology, is designed to highlight current concepts of the immunopathology of allergic diseases and other common immunologically mediated diseases. The presentation will appear as sets of images that involve cross-pathology, histopathology, and molecular pathology and will cover a range of topics of ...
Philippe, Joubert, Qutayba, Hamid
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Airway remodeling and persistent airway obstruction in asthma
Journal of Allergy and Clinical Immunology, 1999There is growing recognition that some patients with long-standing asthma may possess a component of irreversible airflow obstruction despite optimal therapy. This persistent airflow obstruction is thought to be the result of structural changes in the airways that occur as a result of airway remodeling.
J E, Fish, S P, Peters
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Interleukin-17 and airway remodelling
Pulmonary Pharmacology & Therapeutics, 2006Interleukin (IL)-17A is emerging as important in reinforcing innate immunity by orchestrating sustained neutrophilic mobilisation. Even though there are indications of association with specific airway diseases, there is still no final proof that IL-17A plays a truly causative pathogenic role. There is evidence in mice that endogenous IL-17A contributes
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[Airway remodeling in asthma].
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2006Asthma is a chronic inflammatory disease of the airways. Structural alteration of the airways and lung parenchyma, "remodeling", is a recognized feature of chronic asthma and a cause of irreversible airway obstruction. Airway and lung remodeling in asthma involves subepithelial fibrosis, but also alterations of bronchial epithelium, airway smooth ...
Aneta, Tomkowicz, Maria, Kraus-Filarska
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Regulation of immune responses by the airway epithelial cell landscape
Nature Reviews Immunology, 2021Richard J Hewitt, Clare Lloyd
exaly