Results 21 to 30 of about 97,688 (260)

Estimating Airway Resistance from Forced Expiration in Spirometry

Applied Sciences, 2019
Spirometry is the gold standard to detect airflow limitation, but it does not measure airway resistance, which is one of the physiological factors behind airflow limitation. In this study, we describe the dynamics of forced expiration in spirometry using
Nilakash Das, Kenneth Verstraete, Marko Topalovic, Jean-Marie Aerts, Wim Janssens   +4 more
doaj   +1 more source

D-4F, an apoA-1 mimetic, decreases airway hyperresponsiveness, inflammation, and oxidative stress in a murine model of asthma[S]

Journal of Lipid Research, 2011
Asthma is characterized by oxidative stress and inflammation of the airways. Although proinflammatory lipids are involved in asthma, therapies targeting them remain lacking. Ac-DW F KA F YDKVAEK F KEA F NH2 (4F) is an apolipoprotein (apo)A-I mimetic that
S.D. Nandedkar, D. Weihrauch, H. Xu, Y. Shi, T. Feroah, W. Hutchins, D.A. Rickaby, N. Duzgunes, C.A. Hillery, K.S. Konduri, Jr.K.A. Pritchard   +10 more
doaj   +1 more source

The Role of Impulse Oscillometry in Evaluating Disease Severity and Predicting the Airway Reversibility in Patients With Bronchiectasis

Frontiers in Medicine, 2022
BackgroundImpulse oscillometry (IOS) can be used to evaluate airway impedance in patients with obstructive airway diseases. Previous studies have demonstrated that IOS parameters differ between patients with bronchiectasis and healthy controls.
Cuiyan Tan, Donghai Ma, Donghai Ma, Kongqiu Wang, Changli Tu, Meizhu Chen, Xiaobin Zheng, Yingjian Liang, Yiying Huang, Zhenguo Wang, Jian Wu, Jin Huang, Jing Liu, Jing Liu   +13 more
doaj   +1 more source

α-Bisabolol alleviates diesel exhaust particle-induced lung injury and mitochondrial dysfunction by regulating inflammatory, oxidative stress, and apoptotic biomarkers through the c-Jun N-terminal kinase signaling pathway

Frontiers in Pharmacology
IntroductionExposure to particulate matter ≤2.5 μm in diameter (PM2.5) is associated with adverse respiratory outcomes, including alterations to lung morphology and function.
Sumaya Beegam, Nur Elena Zaaba, Ozaz Elzaki, Abderrahim Nemmar   +3 more
doaj   +1 more source

Mechanisms and Management of Obstructive Sleep Apnea: A Translational Overview [PDF]

Clinical and Experimental Otorhinolaryngology
Obstructive sleep apnea (OSA) is a common disorder characterized by recurrent episodes of upper airway obstruction during sleep, resulting in apnea and hypopnea.
Yun Jin Kang, Chan-Soon Park
doaj   +1 more source

Upper airway resistance: species-related differences [PDF]

Pneumologie, 2010
In veterinary medicine, upper airway resistance deserves a particular attention in equines athletes and brachycephalic dogs. Due to the anatomical peculiarities of the upper airway and/or pathological conditions, significant alterations of performance and/or well being might occur in horses and dogs. Physiological specificities and pathological changes
Kirschvink, N., Reinhold, P.
openaire   +4 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Acute Effect of Submaximal Exercise on Respiratory System Impedance in Healthy Adults

Journal of Functional Morphology and Kinesiology
Background: Previous studies have experimentally investigated and simulated the effects of dynamic hyperinflation on respiratory system resistance variables in populations with different respiratory diseases.
Thales Henrique do Carmo Furquim, Daniele Oliveira dos Santos, Jéssica Perossi, Fernanda Cristina Lima, Janne Marques Silveira, Ada Clarice Gastaldi   +5 more
doaj   +1 more source