Results 71 to 80 of about 1,534,638 (251)

Ablation of smooth muscle myosin heavy chain SM2 increases smooth muscle contractility and results in postnatal death in mice [PDF]

, 2008
The smooth muscle myosin heavy chains (SMHC) are motor proteins powering smooth muscle contraction. Alternate splicing of SHMC gene at the C-terminus produces SM1, and SM2 myosin isoforms; SM2 (200 kDa) contains a unique 9-amino-acid sequence at the ...
Mei Chi, Gopal Babu, Yingbi Zhou, Muthu Periasamy, Srikanth Vedamoorthyrao   +4 more
core  

Oscillometric assessment of bronchodilator response in horses with severe asthma during remission

Equine Veterinary Journal, EarlyView.
Abstract Background During clinical remission of severe equine asthma (SEA), affected animals can be challenging to distinguish from healthy horses. In humans, the degree of bronchodilation achieved with a β2‐adrenergic bronchodilator is helpful in differentiating asthmatics from healthy subjects.
Séléna de Wasseige, Sophie Mainguy‐Seers, Jean‐Pierre Lavoie   +2 more
wiley   +1 more source

Airway Remodeling in Asthma and Irreversible Airflow Limitation —ECM Deposition in Airway and Possible Therapy for Remodeling—

Allergology International, 2007
Airway remodeling in asthma is characterized by goblet cell hyperplasia, subepithelial fibrosis, and hyperplasia and hypertrophy of airway smooth muscle cells.
Kohei Yamauchi, Hiroshi Inoue
doaj   +1 more source

Engineering an artificial trachea: Quantitative benchmarks and modular strategies for mechanics, epithelialization, and vascular integration

FlexMat, EarlyView.
In this work, we first examine the limitations of surgical repair and stenting, including migration, granulation, mucus plugging, and infection. We then translate these failures into engineering constraints involving geometry, mechanics, fixation, degradation, junctional stress, and remodeling.
Yiwei Xu, Hanqing Dai, Qianwang Ye, Wanlu Zhang, Na Wang, Lei Xiong, Ruiqian Guo   +6 more
wiley   +1 more source

Evaluation of association of blood and bronchoalveolar eosinophil numbers and serum total immunoglobulin E concentration with the expression of nonspecific airway reactivity in dogs [PDF]

, 1997
To characterize the relation between bronchoalveolar and blood eosinophil numbers, serum total IgE concentration, and nonspecific airway reactivity in healthy ...
Muggenburg, B A, Bice, D E, DeBoer, D J, Collie, D D   +3 more
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DNA methylation modules in airway smooth muscle are associated with asthma severity [PDF]

, 2018
Abnormal DNA methylation patterns distinguish airway smooth muscle cell function in asthma and asthma ...
Ian M. Adcock, Galea, Francesca, Flanagan, James M., Mark M. Perry, Adcock, Ian M., Scott Kuo, Chih-hsi, Perry, Mark M, Kian Fan Chung, Perry, Mark M., Francesca Galea, James M. Flanagan, Flanagan, James M, Paul Lavender, Chih-hsi Scott Kuo, Fan Chung, Kian, Charalambos Michaeloudes, Lavender, Paul, Michaeloudes, Charalambos, Kuo, Chih Hsi Scott, Adcock, Ian M   +19 more
core   +1 more source

Syncing Health Timing: Exploring the Interplay of Circadian Rhythms, Obesity, and Cardiovascular Diseases

Food Safety and Health, EarlyView.
Circadian rhythm disruption impairs metabolic regulation, appetite control, and vascular function, promoting obesity and cardiovascular diseases. Evidence highlights a bidirectional relationship where metabolic disorders further disturb circadian timing.
Ghizal Fatima, István Dalmadi, Anna Jánosi, Krisztina Takács, Eszter Halmy   +4 more
wiley   +1 more source

CC-Chemokine CCL15 Expression and Possible Implications for the Pathogenesis of IgE-Related Severe Asthma

Mediators of Inflammation, 2012
Airway inflammation is accompanied by infiltration of inflammatory cells and an abnormal response of airway smooth muscle. These cells secrete chemokines and express the cell surface chemokine receptors that play an important role in the migration and ...
Yasuo Shimizu, Kunio Dobashi
doaj   +1 more source

Kisspeptins inhibit human airway smooth muscle proliferation

JCI Insight, 2022
Sex and gender disparity in asthma is recognized and suggests a modulatory role for sex steroids, particularly estrogen. However, there is a dichotomous role for estrogen in airway remodeling, making it unclear whether sex hormones are protective or ...
Niyati A. Borkar, Nilesh Sudhakar Ambhore, Rama Satyanarayana Raju Kalidhindi, Christina M. Pabelick, Y.S. Prakash, Venkatachalem Sathish   +5 more
doaj   +1 more source

Regulation of Airway Smooth Muscle Proliferation: Cytokine-, Glucocorticoid-, and pKa-Dependent Mechanisms

, 2008
Increased mass of airway smooth muscle (ASM) is an important pathogenic mechanism in the obstructive airway disease asthma. Increased volume of ASM has been attributed to both smooth muscle hyperplasia and hypertrophy, and is thought to be driven by ...
Misior, Anna M
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