Results 81 to 90 of about 1,534,638 (251)
Integrin α9β1 in airway smooth muscle suppresses exaggerated airway narrowing [PDF]
, 2012 Exaggerated contraction of airway smooth muscle is the major cause of symptoms in asthma, but the mechanisms that prevent exaggerated contraction are incompletely understood.
Shokat, Kevan M +23 more
core +1 more source
International Journal of Gynecology &Obstetrics, EarlyView.Integrated approach to menopausal hormone therapy in women with cardiovascular risk factors or established ischemic heart disease, from early treatment initiation and risk stratification to individualized therapy, multidisciplinary follow‐up, and health‐system recommendations.
Chiara Benedetto +9 more
wiley +1 more source
Airway smooth muscle dynamics [PDF]
, 2010 The current study aims to investigate the relative contributions of each of the processes that govern airway smooth muscle mechanical behaviour. Studies have shown that breathing dynamics have a substantial effect on airway constriction in healthy and ...
IJpma, Gijs
core
The extracellular matrix of the lung and airway responsiveness in asthma
Monaldi Archives for Chest Disease, 2016 The extracellular matrix is the main determinant of the structure and of mechanical behaviour of the lung. The extracellular matrix is also responsible for the mechanical interdependence between airway and parenchyma due to the alveolar attachments to ...
F.G. Salerno +5 more
doaj +1 more source
Activation of smooth muscle in the airway wall, force production, and airway narrowing
, 1992 Airway narrowing depends on smooth muscle force production and muscle shortening, but the structural and geometric properties exhibited by individual generations of the bronchial tree largely determine the extent and characteristics of airway narrowing.
T. I. Omari +3 more
core +1 more source
Effect of corticosteroids and long-acting ß2- agonists in a human cell culture based "in vitro" model of airway inflammation and tissue remodeling [PDF]
, 2006 Asthma and chronic obstructive pulmonary disease (COPD) are characterized by chronic airway inflammation and remodeling. In non-pathological conditions tissue homeostasis is maintained by the balance between extracellular matrix (ECM) synthesis and ...
Goulet, Stéphanie
core +1 more source
The Endothelial CXCR Family in Vascular Health and Disease
iNew Medicine, EarlyView.ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu +4 more
wiley +1 more source
Metrnl: A Novel Therapeutic Target in Atherosclerosis
iNew Medicine, EarlyView.ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley +1 more source
The Regulatory Role of miR-107–Cdk6-Rb Pathway in Airway Smooth Muscle Cells in Asthma
, 2023 Yi Xiong,1,2,* Yani Luo,2,* Ting Yuwen,2,* Jiana Li,2 Rongchang Chen,3 Fei Shi1 1Emergency Department, Shenzhen People’s Hospital, Shenzhen, Guangdong Province, People’s Republic of China; 2Biomedical Research Institute, Shenzhen Peking ...
Xiong Y +5 more
core
iNew Medicine, EarlyView.Structural cells (endothelial, epithelial, neural, and muscle) actively participate in innate immunity as primary responders, challenging the traditional leukocyte‐centric paradigm and opening new therapeutic avenues for precision medicine. ABSTRACT Innate immunity has long been viewed as the domain of circulating mobile immune cells orchestrating ...
Sofya Urvanova, Suowen Xu
wiley +1 more source