Results 41 to 50 of about 2,514 (185)

Clonal haematopoiesis in T-follicular helper cell lymphoma: A prognostic biomarker and early event in lymphoma evolution. [PDF]

Br J Haematol
Summary T‐follicular helper cell lymphomas (TFHLs) are frequently associated with epigenetic mutations and clonal haematopoiesis (CH), but the clinical and prognostic implications of CH in TFHL remains unclear. We performed next‐generation sequencing on paired peripheral blood (PB) and tumour tissue samples from 30 patients with TFHL. CH was defined by
Wei C, Zhang Y, Zhao D, Zhang W, Zhou D.
europepmc   +2 more sources

Immune infiltration and drug specificity analysis of different subtypes based on functional status in angioimmunoblastic T-cell lymphoma

Heliyon, 2023
Angioimmunoblastic T-cell lymphoma (AITL) is a subtype of peripheral T-cell lymphoma (PTCL) strongly correlated with worse clinical outcomes. However, the role of characteristic pathway-related genes in patients with AITL (e.g., subtype typing and ...
Shicong Zhu, Yan Zhao, Cheng Xing, Wancheng Guo, Zineng Huang, Huifang Zhang, Le Yin, Xueqin Ruan, Heng Li, Zhao Cheng, Zhihua Wang, Hongling Peng   +11 more
doaj   +1 more source

The Early Diagnostic Dilemma in Angioimmunoblastic T Cell Lymphoma with Excessive Plasma Cells Proliferation

Case Reports in Medicine, 2021
Background. Angioimmunoblastic T cell lymphoma (AITL) is an aggressive Epstein–Barr virus-associated T cell lymphoma. Clinical syndromes of AITL are not confined to fever and lymphadenopathy, and patients may initially present with polyclonal plasma cell
Chunyan Wang, Xia Mao, Songya Liu, Cheng He, Ying Wang, Li Zhu, Yangyang Wang, Yicheng Zhang   +7 more
doaj   +1 more source

Mutation analysis links angioimmunoblastic T-cell lymphoma to clonal hematopoiesis and smoking

eLife, 2021
Background: Although advance has been made in understanding the pathogenesis of mature T-cell neoplasms, the initiation and progression of angioimmunoblastic T-cell lymphoma (AITL) and peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS ...
Shuhua Cheng, Wei Zhang, Giorgio Inghirami, Wayne Tam   +3 more
doaj   +1 more source

Predicting one-year overall survival in patients with AITL using machine learning algorithms: a multicenter study. [PDF]

Sci Rep
Huang X, Zhang C, Liu K, Wu F, Feng T, Xu C.   +5 more
europepmc   +3 more sources

RHOA G17V induces T follicular helper cell specification and involves angioimmunoblastic T-cell lymphoma via upregulating the expression of PON2 through an NF-κB-dependent mechanism

OncoImmunology, 2022
Angioimmunoblastic T-cell lymphoma (AITL) is a malignant hematologic tumor arising from T follicular helper (Tfh) cells. High-throughput genomic sequencing studies have shown that AITL is characterized by a novel highly recurring somatic mutation in RHOA,
Fenglian Que, Lihong Zhang, Taoli Wang, Meifang Xu, Wangen Li, Shengbing Zang   +5 more
doaj   +1 more source

Novel Laboratory Approaches in Heavy Chain Disease With Discordant Immunoglobulin Quantitation: A Case Report and Literature Review. [PDF]

J Clin Lab Anal
In this study, we investigated a rare case of γ‐heavy chain disease (γ‐HCD) through an integrated laboratory approach. Routine protein analyses (serum protein electrophoresis, immunotyping, and serum/urine immunofixation) identified an IgG monoclonal component without detectable light chains.
Longhi E, Çeka A, Olivieri F, Moretti M, Sabbatinelli J.   +4 more
europepmc   +2 more sources

Bortezomib Use for a Critically Ill Patient with Angioimmunoblastic T-Cell Lymphoma

Case Reports in Hematology, 2022
Angioimmunoblastic T-cell lymphoma (AITL) accounts for 18.5% of all peripheral T-cell lymphomas. There is still no gold standard chemotherapy for treating newly diagnosed AITL. This case describes the use of bortezomib in newly diagnosed AITL.
Motoharu Shibusawa
doaj   +1 more source

Successful Treatment of Chidamide and Cyclosporine for Refractory/Relapsed Angioimmunoblastic T Cell Lymphoma With Evans Syndrome: A Case Report With Long-Term Follow-Up

Frontiers in Oncology, 2020
BackgroundRefractory/relapsed angioimmunoblastic T cell lymphoma (AITL) with Evans syndrome is a very rare condition with a poor prognosis. There is no evidence-based treatment strategy for refractory/relapsed AITL with Evans syndrome.Case PresentationA ...
Fang Zhu, Qiuhui Li, Huaxiong Pan, Yin Xiao, Tao Liu, Xinxiu Liu, Juan Li, Gang Wu, Liling Zhang   +8 more
doaj   +1 more source

Recent Advances in Diagnosis and Therapy of Angioimmunoblastic T Cell Lymphoma

Current Oncology, 2021
Angioimmunoblastic T cell lymphoma (AITL) is a common subtype of mature peripheral T cell lymphoma (PTCL). As per the 2016 World Health Organization classification, AITL is now considered as a subtype of nodal T cell lymphoma with follicular helper T ...
Mostafa F. Mohammed Saleh, Ahmed Kotb, Ghada E. M. Abdallah, Ibrahim N. Muhsen, Riad El Fakih, Mahmoud Aljurf   +5 more
doaj   +1 more source