Identification of a neoplastic Tfh-like cellular subset in a mouse model of angioimmunoblastic T cell lymphoma. [PDF]
Front OncolBackgroundNodal T-follicular helper cell lymphoma, angioimmunoblastic type (nTFHL-AI, or AITL), is an aggressive peripheral T cell lymphoma without effective treatments.
Mohammaei S +8 more
europepmc +2 more sources
Prognostic role of whole blood Epstein‑Barr virus DNA load in angioimmunoblastic T-cell lymphoma. [PDF]
Infect Agent CancerObjective The prognostic role of Epstein-Barr virus (EBV) DNA in aggressive angioimmunoblastic T-cell lymphoma (AITL) remains unclear. This study aimed to investigate the prognostic significance of whole blood EBV DNA at diagnosis in AITL patients ...
Zhong Y +15 more
europepmc +2 more sources
The new biology of PTCL‐NOS and AITL: current status and future clinical impact [PDF]
British Journal of Haematology, 2020 SummaryPeripheral T‐cell lymphomas (PTCL) comprise a heterogeneous group of aggressive lymphoproliferative disorders almost all of which are associated with poor clinical outcomes. Angioimmunoblastic T‐cell lymphoma (AITL) and some peripheral T‐cell lymphoma, not otherwise specified (PTCL‐NOS) have similarities to normal CD4+ T‐cell subsets in their ...
Matthew A. Timmins +2 more
openalex +3 more sources
Genetic links in angioimmunoblastic T-cell lymphoma (AITL), clonal hematopoiesis and concomitant hematologic malignancies provide insights into the cell of origin, etiology and biomarker discovery for AITL [PDF]
, 2020 Abstract We generated and compared the mutation profiles through targeted sequencing of the primary tumors and matched bone marrow/peripheral blood samples in 25 patients with angioimmunoblastic T-cell lymphoma (AITL) and 2 with peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS).
S. Cheng +3 more
openalex +2 more sources
Single-cell transcriptomic mapping of immune heterogeneity across angioimmunoblastic T-cell lymphoma subtypes. [PDF]
Biomark ResRelapse and treatment resistance remain critical obstacles in the clinical management of angioimmunoblastic T-cell lymphoma (AITL), limiting the success of current therapeutic strategies.
Liu H +13 more
europepmc +2 more sources
IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interaction with the AITL microenvironment [PDF]
Cancer Cell, 2023 Julie Leca +2 more
exaly +2 more sources
AI in the Loop (AITL): A Systems Taxonomy for Closed-Loop Autonomous Evaluation
We identify and formalize AI In The Loop (AITL), a paradigm where AI systems autonomously generate, evaluate, and improve with human intervention restricted to boundary supervision rather than operational decision-making. AITL extends the RLAIF principle—replacing human feedback with AI feedback—from training to the full AI system lifecycle.
Sanskar jajoo
+9 more sources
Correction to: Cytoplasmic TRBC1 Expression in T-ALL and AITL [PDF]
American Journal of Clinical Pathology, 2023 openalex +2 more sources
The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells [PDF]
Blood, 2007 Laurence De Leval +2 more
exaly +2 more sources
Revealing tumor microenvironmental heterogeneity and prognostic value in angioimmunoblastic T-cell lymphoma via spatial transcriptome sequencing. [PDF]
Cell Death DisAngioimmunoblastic T-cell lymphoma (AITL) represents the second most prevalent subtype of peripheral T-cell lymphoma, characterized by a dismal prognosis.
Zhang X +15 more
europepmc +2 more sources