Results 1 to 10 of about 2,514 (185)

Angioimmunoblastic T‐cell lymphoma: Characterization of clonal T and B cells and a patient‐derived xenograft study of coexisting T‐ and B‐cell proliferation

eJHaem
Introduction Angioimmunoblastic T‐cell lymphoma (AITL) is a rare and aggressive lymphoma with a poor prognosis. AITL is associated with Epstein–Barr virus (EBV)‐positive B cells in most cases, suggesting a possible role for the virus in the pathobiology ...
Xiaoxian Zhao, Deepa Jagadeesh, Juraj Bodo, Lisa Durkin, Daniel J. Lindner, Sarah L. Ondrejka, Eric D. Hsi   +6 more
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Comprehensive Genomic Profiling of Angioimmunoblastic T-Cell Lymphoma (AITL) in Chinese Patients

Blood, 2018
Abstract Background: Angioimmunoblastic T-cell lymphoma (AITL) is an age-related malignant lymphoma, classified as a subtype of mature peripheral T-cell lymphoma. The 2016 revised WHO classification of lymphoid neoplasms proposed AITL as a nodal lymphoma derived from the T follicular helper cell. Extensive genomic analyses
Lihua Zhong, Jianchao Wang, Yanping Chen, Weiqing Lin, Xiaoyan Liu, Ying Dou, Lihua Sun, Songhui Zhao, Xiaowei Dong, Utpal Dave, Kai Wang, Gang Chen   +11 more
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Long-Term Treatment with Romidepsin in Patients with Peripheral T-Cell Lymphoma

Case Reports in Hematology, 2016
Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of aggressive non-Hodgkin lymphomas. Angioimmunoblastic T-cell lymphoma (AITL) is a common subtype of PTCL, and patients with AITL typically have a poor prognosis with limited treatment ...
Claudius Irlé, Jonathan Weintraub
doaj   +1 more source

Cutaneous involvement in angioimmunoblastic T-cell lymphoma

Indian Journal of Dermatology, 2010
Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive non-Hodgkin′s nodal peripheral T-cell lymphoma characterized by general lymphadenopathy, night sweats, fever, hepatosplenomegaly, polyclonal hypergammaglobulinemia, and cutaneous ...
Papadavid Evangelia, Panayiotides Ioannis, Dalamaga Marianna, Katoulis Alexandros, Economopoulos Theofanis, Stavrianeas Nikolaos   +5 more
doaj  

Dependence on mitochondrial respiration of malignant T cells reveals a new therapeutic target for angioimmunoblastic T-cell lymphoma

Cell Death Discovery
Cancer metabolic reprogramming has been recognized as one of the cancer hallmarks that promote cell proliferation, survival, as well as therapeutic resistance. Up-to-date regulation of metabolism in T-cell lymphoma is poorly understood.
Adrien Krug, Rana Mhaidly, Marie Tosolini, Laura Mondragon, Gamze Tari, Adriana Martinez Turtos, Rachel Paul-Bellon, Vahid Asnafi, Sandrine Marchetti, Léa Di Mascio, Marion Travert, Frédéric Bost, Emmanuel Bachy, Rafael J. Argüello, Jean-Jacques Fournié, Philippe Gaulard, François Lemonnier, Jean-Ehrland Ricci, Els Verhoeyen   +18 more
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A Rare Case of Angioimmunoblastic T-Cell Lymphoma with Epstein-Barr Virus-Negative Reed-Sternberg-Like B-Cells, Chylous Ascites, and Chylothorax

Case Reports in Hematology, 2017
Angioimmunoblastic T-cell lymphoma is a rare non-Hodgkin lymphoma with dismal prognosis. The median age of presentation ranges from 62 to 69 years with generalized lymphadenopathy, B symptoms, and hepatosplenomegaly as the most prevalent symptoms.
Mathijs Willemsen, Arne W. J. H. Dielis, Iryna V. Samarska, Ad Koster, Arienne M. van Marion   +4 more
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Sustained yet non-curative response to lenalidomide in relapsed angioimmunoblastic T-cell lymphoma with acquired chidamide resistance: a case report with 10-year follow-up, genetic insights and literature review

Frontiers in Oncology
Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive subtype of peripheral T-cell lymphoma (PTCL) characterized by its T-follicular helper (TFH) phenotype. Relapsed and refractory disease is common in AITL and often associated with a poor prognosis.
Juan Xu, Jie Huang, Liping Xie, Ting Liu, Jianjun Li, Xinchuan Chen, Zhigang Liu, Sha Zhao, Caigang Xu, Caigang Xu, Yu Wu   +10 more
doaj   +1 more source

Inhibition of choline metabolism in an angioimmunoblastic T-cell lymphoma preclinical model reveals a new metabolic vulnerability as possible target for treatment

Journal of Experimental & Clinical Cancer Research
Background Angioimmunoblastic T-cell lymphoma (AITL) is a malignancy with very poor survival outcome, in urgent need of more specific therapeutic strategies. The drivers of malignancy in this disease are CD4+ follicular helper T cells (Tfh).
Adrien Krug, Marie Tosolini, Blandine Madji Hounoum, Jean-Jacques Fournié, Roger Geiger, Matteo Pecoraro, Patrick Emond, Philippe Gaulard, François Lemonnier, Jean-Ehrland Ricci, Els Verhoeyen   +10 more
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A case of angioimmunoblastic T-cell lymphoma presenting with migration of lung shadows

Respiratory Medicine Case Reports
A 62-year-old woman presented with chronic cough. Chest CT showed multiple nodules and consolidation. Bronchoscopy could not confirm a specific diagnosis. Because her symptoms and lung opacities improved spontaneously, she was followed without treatment.
Tomoya Maruyama, Takashi Ishiguro, Kenji Takano, Yoshihiko Shimizu   +3 more
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S229: CHARACTERISATION OF TUMOR MICROENVIROMENT REMODELLING IN THE PROGRESSION OF AITL WITH SINGLE-CELL RNA SEQUENCING AND IMAGING MASS CYTOMETRY

, 2022
Hui Jin, Xingyu Lu, Lu Fan, Lan Cao, Wen Zhang, J. Li, Zheng Wu   +6 more
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