Results 111 to 120 of about 573,336 (261)
Advanced Healthcare Materials, EarlyView.Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu +10 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Preparation of RVG‐modified erythrocyte membrane‐coated HMPB nanocarriers loaded with L‐arginine and NBP (RM@HPAN) and its neuroprotective mechanism. After intravenous injection, RM@HPAN achieves prolonged circulation, RVG‐29‐mediated BBB penetration, and ischemic accumulation.
Shaofa Li +9 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Self‐healing assembly of two cell‐laden hydrogel layers creates a biomimetic skin construct that restores both dermal and epidermal functions, resulting in accelerated wound healing and enhanced hair follicle regeneration in a full‐thickness skin wound model. ABSTRACT Alopecia remains a pervasive clinical challenge, largely owing to the limited ability
JaeWook Park +5 more
wiley +1 more source
Advanced Materials, EarlyView.Micro‐topographical cues applied through temporally controlled microscale confinement improve the reproducibility, spatial organization, and neurosensory‐associated features of pluripotent stem cell‐derived inner ear organoids. Integration with a vascularized organoid platform further enables controlled investigation of vascular‐epithelial interactions
Harshita Sharma +15 more
wiley +1 more source
Advanced Materials for Biologics Delivery to Brain Tumors
Advanced Materials, EarlyView.Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng +4 more
wiley +1 more source
Advanced Science, EarlyView.IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu +8 more
wiley +1 more source
Figure 8: NDNF Rejuvenated Old hBM-MSCs and Improved Cardiac Function Through Activation of p-Akt
, 2019 (A) The phosphorylated Akt (p-Akt) level in old NDNF-transduced hBM-MSCs (old+NDNF) was significantly higher than in empty vector–transduced cells (old). (B) Western blotting showed the expression of p-Akt protein in the border area of mouse heart tissue
Ren-Ke Li (567108) +13 more
core +1 more source
Advanced Science, EarlyView.The role of TNFα in the process of renal allograft interstitial fibrosis is complex and multifaceted. As it can promote renal allograft interstitial fibrosis by inducing mitochondrial dysfunction and EndMT, and also mediating compensatory mitophagy through the NEDD4–HIF‐1α–BNIP3 pathway, which clears damaged mitochondria and inhibits EndMT, thereby ...
Dengyuan Feng +15 more
wiley +1 more source
, 2018 Figure S1 Total AKT level is not changed in Mig-6 f/f and Mig-6 d/d mice. (A) The expression of AKT in the uteri of Mig-6 f/f (a) and Mig-6 d/d (b) mice and (B) H-score of AKT in the uteri of Mig-6 f/f and Mig-6 d/d mice.
Jung-Yoon Yoo (462528) +5 more
core +1 more source