Results 141 to 150 of about 573,336 (261)

Zugspitz-Waffeln Schutzmarke, Landshuter Bisquit- & Keksfabrik, H.L. Klein Akt. Ges. Landshut i./B.

ZUGSPITZ-WAFFELN SCHUTZMARKE, LANDSHUTER BISQUIT- & KEKSFABRIK, H.L. KLEIN AKT. GES. LANDSHUT I./B. Zugspitz-Waffeln Schutzmarke, Landshuter Bisquit- & Keksfabrik, H.L. Klein Akt. Ges. Landshut i./B. ( -
H.L. Klein Akt. Ges.
core   +1 more source

Cobalt Single‐Atom Nanozyme for Enhanced Intestinal Radioprotection and Tumor Radiosensitization via Bidirectional ROS Modulation

Advanced Science, EarlyView.
Orally administered, pH‐responsive Co‐SAN exerts dual functions: in the alkaline intestinal milieu, it scavenges reactive oxygen species (ROS) and suppresses the PI3K/AKT pathway and NETs formation, thus providing radioprotection; whereas in the acidic tumor microenvironment, it generates ROS and alleviates hypoxia, thereby enhancing radiosensitization.
Shengqi Yin, Junjie Li, Yishu Zou, Yang Liu, Yilin Zheng, Lu Yu, Wanying Zheng, Yajun Zou, Zehui Zhang, Tao Li, Peiqun Yin, Jianlin Zhang, Yuen Wu, Yi Ding   +13 more
wiley   +1 more source

Schüller & Co. Akt. Ges. Gestrickte Kinderbekleidung, Wien, St. Pölten, Litschau, Unterradlberg, S.C.W.

SCHÜLLER & CO. AKT. GES. GESTRICKTE KINDERBEKLEIDUNG, WIEN, ST. PÖLTEN, LITSCHAU, UNTERRADLBERG, S.C.W. Schüller & Co. Akt. Ges. Gestrickte Kinderbekleidung, Wien, St. Pölten, Litschau, Unterradlberg, S.C.W. ( -
Schüller & Co. Akt. Ges.
core   +1 more source

Dissimilar Immunohistochemical Expression of ERK and AKT between Paired Biopsy and Hepatectomy Tissues of Hepatocellular Carcinoma

, 2014
Background/Aim: Biomarker studies using immunohistochemical (IHC) staining have not been successful for advanced hepatocellular carcinoma (HCC). We aimed to examine whether the tissue procurement process influences the protein expression levels detected ...
邵幼雲 ;鄭安理 ;徐志宏 ;何明志, Shao, Yu-Yun;Chen, Chi-Long;Ho, Ming-Chih;Huang, Chien-Chung;Tu, Hui-Ching;Hsu, Chih-Hung;Cheng, Ann-Lii   +1 more
core  

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

LONP2 Enhances Cervical Cancer Growth and Metastatic Potential by Upregulating PLS3 and Activating PI3K/AKT Signaling. [PDF]

Cancer Manag Res
Yang Y, Sun J, Tian L, Liao J.
europepmc   +1 more source

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, EarlyView.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source

PI3K/AKT signaling pathway: molecular crossroads in tumorigenesis and therapeutic innovation. [PDF]

Signal Transduct Target Ther
Shi Q, Liu J, Chu Q, Zeng Y, Zhang Y, Jiang S, Yuan X, Zhu D, Li L.   +8 more
europepmc   +1 more source

TRAF6 Lactylation in Glycolytic Macrophages Drives NF‐κB Signaling and M1 Polarization During Orthodontic Tooth Movement

Advanced Science, EarlyView.
Schematic diagram showing compressive stress triggers glycolytic reprogramming and lactate accumulation in macrophages. Lactate mediates TRAF6 lactylation at K171/K180 dual sites, which enhances its K63‐linked ubiquitination to activate the NF‑κB pathway and promote M1 polarization. This cascade drives orthodontic tooth movement (OTM) and alveolar bone
Xinyi He, Guodong Zhao, Yun Hu, Wenya Bai, Hao Tan, Shuai Yuan, Sihan Yang, Ye Zhu, Xiaohui Xu, Leilei Zheng   +9 more
wiley   +1 more source

The role of mTORC2/RICTOR in immune cells and inflammatory diseases. [PDF]

Inflamm Res
Xu J, Zhong W, Xin F, Xu F, Zheng Z, Guo F.   +5 more
europepmc   +1 more source