Akt Is S-Palmitoylated: A New Layer of Regulation for Akt [PDF]
Frontiers in Cell and Developmental Biology, 2021 The protein kinase Akt/PKB participates in a great variety of processes, including translation, cell proliferation and survival, as well as malignant transformation and viral infection. In the last few years, novel Akt posttranslational modifications have been found.
Matías Blaustein +23 more
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AKT crystal structure and AKT-specific inhibitors [PDF]
Oncogene, 2005 AKT kinases are attractive targets for small molecule drug discovery because of their key role in tumor cell survival/proliferation and their overexpression/activation in many human cancers. This review summarizes studies that support the rationale for targeting AKT kinases in new drug discovery efforts.
Chandra C, Kumar, Vincent, Madison
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Current Perspectives on Akt Akt-ivation and Akt-ions
Experimental Biology and Medicine, 2009 The serine/threonine kinase Akt is an effector of PI3K-generated phosphatidylinositol ( 3 , 4 , 5 )-trisphosphate [PI( 3 , 4 , 5 )P3] and is a principle mediator of growth factor-induced signal transduction. Akt is activated through phosphorylation by specific kinases, and its activity is reduced directly by phosphorylation-site-specific phosphatases ...
Ronald W, Matheny, Martin L, Adamo
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Phospho-Akt expression is high in a subset of triple negative breast cancer patients [PDF]
, 2014 The most commonly used biomarkers to predict the response of breast cancer patients to therapy are oestrogen receptor (ER), progesterone receptor (PgR), and human epidermal growth factor receptor 2 (HER2).
Baldacchino, Shawn +6 more
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adaptive capabilities of the pi3k/akt/mtor pathway in acute myeloid leukemia revealed by the use of selective inhibitors [PDF]
, 2013 Because of its aberrant activation, the PI3K/AKT/mTOR signaling pathway represents a pharmacological target in blast cells from patients with acute myelogenous leukemia (AML).
Bertacchini, Jessika <1980>
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, 2022 Evaluation of phospho-Akt, downstream of CXCL12, in GFP-positive U937 under mono- or co-culture conditions. Phospho-Akt was increased in U937 co-cultured with RHBDD2-CKO HEK293T for 48 h.
Morito Kurata (8164626)
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InterAKTions with FKBPs - mutational and pharmacological exploration [PDF]
, 2013 The FK506-binding protein 51 (FKBP51) is an Hsp90-associated co-chaperone which regulates steroid receptors and kinases. In pancreatic cancer cell lines, FKBP51 was shown to recruit the phosphatase PHLPP to facilitate dephosphorylation of the kinase Akt,
Andreas März +29 more
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Activation of Akt at T308 and S473 in alcohol, tobacco and HPV-induced HNSCC:is there evidence to support a prognostic or diagnostic role? [PDF]
, 2014 BACKGROUND: Tobacco, alcohol and HPV infection are associated with increased risk of HNSCC. However, little is known about the underlying signaling events influencing risk.
Ellis, Ian R.; id_orcid +9 more
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Akt Inhibitor Akt-IV Blocks Virus Replication through an Akt-Independent Mechanism [PDF]
Journal of Virology, 2009 ABSTRACTMany viruses activate the phosphatidylinositol 3′-kinase (PI3k)/Akt intracellular signaling pathway to promote viral replication. We have analyzed whether a rapidly replicating rhabdovirus, vesicular stomatitis virus (VSV), requires the PI3k/Akt signaling pathway for its replication.
Ewan F, Dunn +2 more
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Oligonucleotides suppress PKB/Akt and act as superinductors of apoptosis in human keratinocytes [PDF]
, 2009 DNA oligonucleotides (ODN) applied to an organism are known to modulate the innate and adaptive immune system. Previous studies showed that a CpG-containing ODN (CpG-1-PTO) and interestingly, also a non-CpG-containing ODN (nCpG- 5-PTO) suppress ...
Annette Dorn +19 more
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