Results 31 to 40 of about 532,309 (312)

Type II transmembrane serine proteases 4 (TMPRSS4) promotes proliferation, invasion and epithelial–mesenchymal transition in endometrial carcinoma cells (HEC1A and Ishikawa) via activation of MAPK and AKT

open access: yesAnimal Cells and Systems, 2021
Endometrial cancer is the most common gynecological cancer in the developed countries. Type II transmembrane serine proteases 4 (TMPRSS4) is a newly discovered transmembrane protein, which may be related to the invasion, metastasis of the tumor and the ...
Huan Xiao   +4 more
doaj   +1 more source

Yi–Qi–Jian–Pi–Xiao–Yu–Xie–Zhuo Formula Improves Muscle Atrophy via Modulating the IGF-1/PI3K/Akt Signaling Pathway in 5/6 Nephrectomized Rats

open access: yesFrontiers in Pharmacology, 2021
The Yi–Qi–Jian–Pi–Xiao–Yu–Xie–Zhuo (YQJPXYXZ) formula has been used for treating chronic kidney disease (CKD) for many years with good efficiency based on the cumulative empirical experience of previous practitioners.
Hong Xia   +11 more
doaj   +1 more source

The Akt of translational control [PDF]

open access: yesOncogene, 2005
The oncogene AKT (also called protein kinase B (PKB)) signals to the translational machinery, and activation of protein synthesis by Akt is associated with cancer formation. Akt directly stimulates the activity of translation initiation factors and upregulates ribosome biogenesis.
Davide, Ruggero, Nahum, Sonenberg
openaire   +2 more sources

Fig. 4f. phospho-Akt

open access: yes, 2022
Evaluation of phospho-Akt, downstream of CXCL12, in GFP-positive U937 under mono- or co-culture conditions. Phospho-Akt was increased in U937 co-cultured with RHBDD2-CKO HEK293T for 48 h.
Morito Kurata (8164626)
core   +1 more source

Character study based on the conditions of employment of a Professor of Mathematics de Toux at Michał Kazimierz Radziwiłł "Rybeńko"

open access: yesArchiwa - Kancelarie - Zbiory, 2012
At the moment lack of subject specific literature does not allow more thorough description of main duties, responsibilities, and salaries of magnate's secretaries. In many cases social background and education of these secretaries remains a mystery.
Rafał Jankowski
doaj   +1 more source

A Small Molecule Inhibits Akt through Direct Binding to Akt and Preventing Akt Membrane Translocation [PDF]

open access: yesJournal of Biological Chemistry, 2010
The Akt pathway is frequently hyperactivated in human cancer and functions as a cardinal nodal point for transducing extracellular and intracellular oncogenic signals and, thus, presents an exciting target for molecular therapeutics. Here we report the identification of a small molecule Akt/protein kinase B inhibitor, API-1.
Donghwa, Kim   +8 more
openaire   +4 more sources

Aspek Kepemimpinan Manajemen, Praktik Manajemen Mutu Terpadu, dan Quality Performance: Analisa PLS-Path Modeling

open access: yesJurnal Dinamika Akuntansi dan Bisnis, 2019
This study aims to predict the causal relationships between management leadership, total quality management practices, and quality performance. Data is collected from a survey through the distribution of questionnaires.
Kurniawan Tjakrawala, Nurainun Bangun
doaj   +1 more source

Repairing hearts with AKT [PDF]

open access: yesProceedings of the National Academy of Sciences, 2015
Adult cardiomyocytes—the contractile units of the heart—have little regenerative capacity, and their loss, following ischemic injury and other insults, leads to cardiac dysfunction and heart failure, a degenerative condition with a poorer prognosis than many cancers. Despite intense efforts, there are presently no effective treatments for heart failure
Hiba, Komati, Mona, Nemer
openaire   +2 more sources

Inhibitory Effect of Hesperidin on the Expression of Programmed Death Ligand (PD-L1) in Breast Cancer

open access: yesMolecules, 2020
Programmed death ligand 1 (PD-L1) is overexpressed in the most aggressive breast cancer subtype, triple-negative breast cancer (TNBC), assisting the eradication of antitumor immunity, and thereby enhancing the survival of the tumor.
Prachya Kongtawelert   +4 more
doaj   +1 more source

Analysis of expression pattern of proteins associated with AKT/mTOR signaling pathway in kidney cancer development

open access: yesAnnals of Medical Science and Research, 2022
Introduction: The purpose of this study was to analyze the expression status, reciprocal interplay, and prognostic significance of AKT1 and hypoxia-inducible factor 1 alpha (HIF-1α) in AKT/mechanistic target of the rapamycin pathway and to enable them to
Ritesh Satardey   +3 more
doaj   +1 more source

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