Results 241 to 250 of about 37,267 (288)

Microglial Drivers of Alzheimer's Disease Pathology: An Evolution of Diverse Participating States

Proteins: Structure, Function, and Bioinformatics, Volume 93, Issue 8, Page 1330-1348, August 2025.
ABSTRACT Microglia, the resident immune‐competent cells of the brain, become dysfunctional in Alzheimer's disease (AD), and their aberrant immune responses contribute to the accumulation of pathological proteins and neuronal injury. Genetic studies implicate microglia in the development of AD, prompting interest in developing immunomodulatory therapies
Madison K. Kuhn, Elizabeth A. Proctor
wiley   +1 more source

Clonal hematopoiesis of indeterminate potential in patients with immunoglobulin light-chain AL amyloidosis. [PDF]

Blood Adv
Lopedote P, Evans B, Marchetti A, Chen T, Moscvin M, Boullt S, Bolli N, Bianchi G.   +7 more
europepmc   +1 more source

Cytological Assessment of Adrenal Tumours: Insights From 22‐Years Single Centre Experience

Clinical Endocrinology, Volume 103, Issue 2, Page 157-166, August 2025.
ABSTRACT Objective The incidence of adrenal tumours has increased in the last decades, mainly due to increased use of imaging. The diagnostic evaluation of adrenal masses can be complex and, in some cases, necessitates cytological evaluation. However, concerns remain regarding the potential complications associated with adrenal gland biopsy.
Ana Carasel, Jan Calissendorff, C. Christofer Juhlin, Henrik Falhammar   +3 more
wiley   +1 more source

Lung Transplantation for Pulmonary AL Amyloidosis. [PDF]

Transplant Direct
Ehrlich MI, Hughes MS, Labadie BW, Siegelin MD, D'Ovidio F, Bijou R, Lentzsch S, Arcasoy SM.   +7 more
europepmc   +1 more source

New approach to specific Alzheimer's disease diagnosis based on plasma biomarkers in a cognitive disorder cohort

European Journal of Clinical Investigation, Volume 55, Issue 8, August 2025.
Abstract Background The validation of a combination of plasma biomarkers and demographic variables is required to establish reliable cut‐offs for Alzheimer's disease diagnosis (AD). Methods Plasma biomarkers (Aβ42/Aβ40, p‐Tau181, t‐Tau, NfL, GFAP), ApoE genotype, and demographic variables were obtained from a retrospective clinical cohort of cognitive ...
Lourdes Álvarez‐Sánchez, Laura Ferré‐González, Carmen Peña‐Bautista, Ángel Balaguer, Julián Luis Amengual, Miguel Baquero, Laura Cubas, Bonaventura Casanova, Consuelo Cháfer‐Pericás   +8 more
wiley   +1 more source

Role of Palliative Care in the Supportive Management of AL Amyloidosis-A Review. [PDF]

J Clin Med
Habib MH, Tiger YKR, Dima D, Schlögl M, McDonald A, Mazzoni S, Khouri J, Williams L, Anwer F, Raza S.   +9 more
europepmc   +1 more source

Bridging the gap in obesity research: A consensus statement from the European Society for Clinical Investigation

European Journal of Clinical Investigation, Volume 55, Issue 8, August 2025.
This consensus highlights critical research gaps in obesity epidemiology, phenotypic heterogeneity and clinical management, calling for advanced methodologies, collaborative strategies and innovative policies to mitigate the global obesity epidemic and its socio‐economic impacts.
Federico Carbone, Jean‐Pierre Després, John P. A. Ioannidis, Ian J. Neeland, Gabriella Garruti, Luca Busetto, Luca Liberale, Stefano Ministrini, Gemma Vilahur, Thomas H. Schindler, Maria Paula Macedo, Agostino Di Ciaula, Marcin Krawczyk, Andreas Geier, Gyorgy Baffy, Maria Felicia Faienza, Ilaria Farella, Nicola Santoro, Gema Frühbeck, Patricia Yárnoz‐Esquiroz, Javier Gómez‐Ambrosi, Emma Chávez‐Manzanera, Verónica Vázquez‐Velázquez, Jean‐Michel Oppert, Dimitrios N. Kiortsis, Paolo Sbraccia, Carmine Zoccali, Piero Portincasa, Fabrizio Montecucco   +28 more
wiley   +1 more source

Redefining Cardiac Involvement and Targets of Treatment in Systemic Immunoglobulin AL Amyloidosis.

JAMA Cardiol
Porcari A, Masi A, Martinez-Naharro A, Razvi Y, Patel R, Ioannou A, Rauf MU, Sinigiani G, Wisniowski B, Filisetti S, Currie-Cathey J, O'Beara S, Kotecha T, Knight D, Moon JC, Sinagra G, Virsinskaite R, Gilbertson J, Venneri L, Petrie A, Lachmann H, Whelan C, Kellman P, Ravichandran S, Cohen O, Mahmood S, Manisty C, Hawkins PN, Gillmore JD, Wechalekar AD, Fontana M.   +30 more
europepmc   +1 more source

Amyloidogenic immunoglobulin light chains disturb contractile function and calcium transients in a human cardiac spheroid model of light chain (AL) amyloidosis. [PDF]

Sci Rep
Bézard M, Vartanian-Grimaldi JS, Henri J, Calin D, Zaroui A, Kharoubi M, Damy T, Agbulut O, Kordeli E.   +8 more
europepmc   +1 more source

The Spectrum of Epidermolysis Bullosa in KwaZulu‐Natal, South Africa

International Journal of Dermatology, Volume 64, Issue 8, Page 1425-1433, August 2025.
ABSTRACT Background Epidermolysis bullosa (EB) is a rare, heterogeneous genodermatosis characterized by skin fragility due to inherited defects in genes encoding proteins that maintain epidermal–dermal integrity. The severity and complications of EB vary by subtype, and no cure currently exists. The epidemiology is unknown in South Africa. Methods This
Antoinette Chateau, Thirona Naicker, Cassandra Bruce‐Brand, Johann Schneider, Colleen Aldous, Ncoza Dlova, Hui‐Ching Cheng, Pei‐Chi Lin, Hsin‐Yu Huang, Chao‐Kai Hsu, John A. McGrath   +10 more
wiley   +1 more source