Results 111 to 120 of about 614,051 (372)

Metabolomics Reveal d-Alanine:d-Alanine Ligase As the Target of d-Cycloserine in Mycobacterium tuberculosis

ACS Medicinal Chemistry Letters, 2013
Stable isotope-mass spectrometry (MS)-based metabolomic profiling is a powerful technique for following changes in specific metabolite pool sizes and metabolic flux under various experimental conditions in a test organism or cell type.
G. Prosser, L. P. S. de Carvalho
semanticscholar   +1 more source

Sonochemical Functionalization of Glass

Advanced Functional Materials, EarlyView.
A new method for functionalizing glass using ultrasonication of aryl diazonium salts. Aryl radicals generated by ultrasounds react with glass, forming a stable, covalently bonded organic film. The functionalized glass adheres microorganisms such as microalgae, fungi, and bacteria, suggesting potential applications in enzyme production, filtration ...
Tiexin Li, Zane Datson, Sufia Hena, Steven Chang, Shane Werry, Leqi Zhao, Nasim Amiralian, Tejas Bhatelia, Francisco J. Lopez‐Ruiz, Melanie MacGregor, K. Swaminathan Iyer, Simone Ciampi, Muhammad J. A. Shiddiky, Nadim Darwish   +13 more
wiley   +1 more source

High alanine aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetes.

Diabetes, 2002
It has been proposed that liver dysfunction may contribute to the development of type 2 diabetes. The aim of the present study was to examine whether elevated hepatic enzymes (alanine aminotransferase [ALT], aspartate aminotransferase [AST], or gamma ...
B. Vozarova, N. Stefan, R. Lindsay, A. Saremi, R. Pratley, C. Bogardus, P. Tataranni   +6 more
semanticscholar   +1 more source

A Proof‐of‐Principle Demonstration: Exploring the Effect of Anode Layer Microstructure on the Alkaline Oxygen Evolution Reaction

Advanced Functional Materials, EarlyView.
Highlighting the importance of anode microstructure for alkaline OER, ultrasonic spray coating is applied at two different temperatures. This proof‐of‐concept approach yielded varied morphologies, structures, wettability and mechanical strength. These variations led to noticeable performance changes in activity after 8 h of measurements, comparing the ...
Adarsh Jain, Christian Marcks, Lars Grebener, Jacob Johny, Ahammed Suhail Odungat, Mohit Chatwani, Mena‐Alexander Kräenbring, Abhishek Shaji, Marc Frederic Tesch, Anna K. Mechler, Vineetha Vinayakumar, Doris Segets   +11 more
wiley   +1 more source

Effect of beta-alanine, with and without sodium bicarbonate, on 2000-m rowing performance.

International Journal of Sport Nutrition & Exercise Metabolism, 2013
PURPOSE To examine the effect of beta-alanine only and beta-alanine with sodium bicarbonate supplementation on 2,000-m rowing performance. METHODS Twenty well-trained rowers (age 23 ± 4 y; height 1.85 ± 0.08 m; body mass 82.5 ± 8.9 kg) were assigned to
R. Hobson, R. Harris, Dan Martin, Perry Smith, B. Macklin, B. Gualano, C. Sale   +6 more
semanticscholar   +1 more source

Alleviation of Aging‐Related Hallmarks in a Mouse Model of Progeria via a Nanoparticle‐Based Artificial Transcription Factor

Advanced Functional Materials, EarlyView.
Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim, Junyeop Kim, Euiyeon Lee, Brandon Conklin, Yannan Hou, Sumin Kim, Yerim Hwang, Ki‐Bum Lee, Jongpil Kim   +8 more
wiley   +1 more source

Thermodynamics of helix-coil transitions studied by multicanonical algorithms [PDF]

arXiv, 1995
Thermodynamics of helix-coil transitions in amino-acid homo-oligomers are studied by the recently proposed multicanonical algorithms. Homo-oligomers of length 10 are considered for three characteristic amino acids, alanine (helix former), valine (helix indifferent), and glycine (helix breaker).
arxiv  

Enantiospecific alkylations of alanine

Journal of the Chemical Society, Perkin Transactions 1, 1998
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Alonso, F, Davies, S, Elend, A, Haggitt, J   +3 more
openaire   +3 more sources

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

Advanced Functional Materials, EarlyView.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci, Matthias Sandmeier, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

Genetic correlation between circulating metabolites and chalazion: a two-sample Mendelian randomization study

Frontiers in Molecular Biosciences
Background: Lipid metabolism disorders were observationally associated with chalazion, but the causality of the related circulating metabolites on chalazion remained unknown.
Xin Zhang, Yuying Cai, Yaping Jiang, Wei Du, Weishu An, Qiangqiang Fu, Yihui Chen   +6 more
doaj   +1 more source