Results 91 to 100 of about 592,791 (266)

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

Catabolism of germinant amino acids is required to prevent premature spore germination in Bacillus subtilis

mBio
Spores of Bacillus subtilis germinate in response to specific germinant molecules that are recognized by receptors in the spore envelope. Germinants signal to the dormant spore that the environment can support vegetative growth, so many germinants, such ...
Iqra R. Kasu, Octavio Reyes-Matte, Alejandro Bonive-Boscan, Alan I. Derman, Javier Lopez-Garrido   +4 more
doaj   +1 more source

Combination of Alanine and Glutathione as Targeting Ligands of Nanoparticles Enhances Cargo Delivery into the Cells of the Neurovascular Unit

Pharmaceutics, 2020
Inefficient drug delivery across the blood–brain barrier (BBB) and into target cells in the brain hinders the treatment of neurological diseases. One strategy to increase the brain penetration of drugs is to use vesicular nanoparticles functionalized ...
Gergő Porkoláb, Mária Mészáros, András Tóth, Anikó Szecskó, András Harazin, Zsolt Szegletes, Györgyi Ferenc, András Blastyák, Lajos Mátés, Gábor Rákhely, Mária A. Deli, Szilvia Veszelka   +11 more
doaj   +1 more source

Developing and Evaluating a Laboratory‐Based Frailty Index for the Prediction of Long‐Term Health Outcomes in Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective We aimed to construct and evaluate the first laboratory‐based frailty index (FI‐Lab) for predicting adverse outcomes in systemic lupus erythematosus (SLE) and to compare its predictive ability to that of an existing clinical FI. Methods We used data from a single‐center prospective cohort of adult patients with SLE whose baseline visit ...
Grace Burns, Samuel D. Searle, Alexandra Legge   +2 more
wiley   +1 more source

Alanine Water Complexes [PDF]

, 2016
Two complexes of alanine with water, alanine–(H2O)n (n = 1,2), have been generated by laser ablation of the amino acid in a supersonic jet containing water vapor and characterized using Fourier transform microwave spectroscopy. In the observed complexes,
M. Eugenia Sanz (1822396), Santiago Mata (1291548), Carlos Cabezas (1291551), José L. Alonso (1291563), Vanesa Vaquero (1822399), Juan C. López (1291557), Isabel Peña (1291545)   +6 more
core   +1 more source

Real‐World Longitudinal Data on the Impact of Hydroxychloroquine Blood Level Monitoring on Lupus Outcomes: Results of a Prospective Longitudinal Cohort Study

Arthritis Care &Research, EarlyView.
Objective Hydroxychloroquine (HCQ) is a cornerstone therapy in systemic lupus erythematosus (SLE), but the weight‐based dosing does not account for clinical factors that can introduce individual variability in drug metabolism and clearance. We leveraged longitudinal data from a prospective SLE cohort to identify clinical factors that predict ...
Jay J. Patel, Fauzia Hollangel, Caroline Packee, Amita Kapoor, Brad Rovin, Nathalie Costedoat‐Chalumeau, Shivani Garg   +6 more
wiley   +1 more source

Germination of Bacillus cereus spores in response to L-alanine and to inosine: the roles of gerL and gerQ operons [PDF]

, 2002
Bacillus cereus 569 (ATCC 10876) endospores germinate in response to inosine or L-alanine, the most rapid germination response being elicited by a combination of these germinants.
Clements, M.O., Barlass, P.J., Houston, C.W., Moir, A.   +3 more
core  

Alanine Water Complexes [PDF]

, 2014
Two complexes of alanine with water, alanine-(H2O)n (n = 1,2), have been generated by laser ablation of the amino acid in a supersonic jet containing water vapor and characterized using Fourier transform microwave spectroscopy. In the observed complexes,
Santiago Mata, Alonso, José L, Carlos Cabezas, López, Juan C, M. Eugenia Sanz, Isabel Peña, Juan C. López, Vaquero, Vanesa, José L. Alonso, Peña, Isabel, Vanesa Vaquero, Cabezas, Carlos, Sanz, Maria Eugenia; id_orcid, Mata, Santiago   +13 more
core   +1 more source

Intrinsic Photoactive Star ZnPc–Poly(glutamate) Nanoplatforms for Multimodal Glioblastoma Therapy and Brain‐Targeted Delivery

Advanced Functional Materials, EarlyView.
An intrinsic photoactive star‐shaped zinc phtalocyanine‐poly(L‐glutamic acid) (ZnPc‐PGA) nanoplatform for multimodal glioblastoma (GBM) therapy and brain‐targeted elivery. A ZnPc‐PGA‐based multifunctional theranostic nanocarrier platform enables image‐guided, multimodal GBM therapy. ZnPc‐PGA nanocarriers support the integration of fluorescence imaging,
Amina Benaicha‐Fernández, Teodora Ranđelović, Ana Armiñán, Víctor Sebastián, Manuel Fuentes, Cristián Huck‐Iriart, Esther Masiá, Paula Carrascosa‐Marco, Pablo Juanes‐Velasco, Snežana Đorđević, Clara Bayona, Ignacio Ochoa, Maria Medel, Inmaculada Conejos‐Sánchez, María J. Vicent   +14 more
wiley   +1 more source

Alanine scanning. [PDF]

, 2014
Alanine scanning.
Carmine Marco Morgillo (655613), F. Javier Luque (60532), Aldo Galeone (12060), Alfredo Fusco (13561), Stefania Correale (655612), Bruno Catalanotti (655615), Pierlorenzo Pallante (568843), Laura Zaccaro (633090), Antonella Federico (568845), Emilia Pedone (655614), Ivan de Paola (633086)   +10 more
core   +1 more source