Results 91 to 100 of about 590,361 (310)

Deep Eutectic Solvent-Mediated FA‑g‑β-Alanine-co-PCL Drug Carrier for Sustainable and Site-Specific Drug Delivery

, 2018
An amphiphilic polymer that consisted of a deep eutectic solvent (DES)-mediated drug carrier was designed, where the DES influenced the formation of folic acid (FA)-tagged g-β-alanine-co-PCL polymer (DES@FA-g-β-alanine-co-PCL); the nature of the carrier ...
Periyakaruppan Pradeepkumar (6014423), Mariappan Rajan (5920097), Naresh Kumar Rajendran (6014426), Murugan A. Munusamy (807158), Mariappan Rajan, Abdullah A. Alarfaj (807157), Periyakaruppan Pradeepkumar, Abdullah A. Alarfaj, Murugan A. Munusamy, Naresh Kumar Rajendran   +9 more
core   +1 more source

Real‐World Longitudinal Data on the Impact of Hydroxychloroquine Blood Level Monitoring on Lupus Outcomes: Results of a Prospective Longitudinal Cohort Study

Arthritis Care &Research, EarlyView.
Objective Hydroxychloroquine (HCQ) is a cornerstone therapy in systemic lupus erythematosus (SLE), but the weight‐based dosing does not account for clinical factors that can introduce individual variability in drug metabolism and clearance. We leveraged longitudinal data from a prospective SLE cohort to identify clinical factors that predict ...
Jay J. Patel, Fauzia Hollangel, Caroline Packee, Amita Kapoor, Brad Rovin, Nathalie Costedoat‐Chalumeau, Shivani Garg   +6 more
wiley   +1 more source

Catabolism of germinant amino acids is required to prevent premature spore germination in Bacillus subtilis

mBio
Spores of Bacillus subtilis germinate in response to specific germinant molecules that are recognized by receptors in the spore envelope. Germinants signal to the dormant spore that the environment can support vegetative growth, so many germinants, such ...
Iqra R. Kasu, Octavio Reyes-Matte, Alejandro Bonive-Boscan, Alan I. Derman, Javier Lopez-Garrido   +4 more
doaj   +1 more source

Combination of Alanine and Glutathione as Targeting Ligands of Nanoparticles Enhances Cargo Delivery into the Cells of the Neurovascular Unit

Pharmaceutics, 2020
Inefficient drug delivery across the blood–brain barrier (BBB) and into target cells in the brain hinders the treatment of neurological diseases. One strategy to increase the brain penetration of drugs is to use vesicular nanoparticles functionalized ...
Gergő Porkoláb, Mária Mészáros, András Tóth, Anikó Szecskó, András Harazin, Zsolt Szegletes, Györgyi Ferenc, András Blastyák, Lajos Mátés, Gábor Rákhely, Mária A. Deli, Szilvia Veszelka   +11 more
doaj   +1 more source

Effects of alanine aminotransferase inhibition on the intermediary metabolism in Sparus aurata through dietary amino-oxyacetate supplementation

, 2011
In liver, through the reaction catalysed by alanine aminotransferase (ALT), alanine becomes an effective precursor for gluconeogenesis. In the present study amino-oxyacetate (AOA) was used to evaluate its effect on liver ALT activity of the carnivorous ...
Felipe Fernández, Viegas, Iván, Fernández González, Felipe Javier, Caballero Solares, Albert, Isidoro Metón, John G. Jones, Isabel V. Baanante, Barra, Joana, Vázquez Baanante, Ma. Isabel, Ivan Viegas, Albert Caballero, Jones, John G., Juan D. González, González, Juan D., Metón Teijeiro, Isidoro, Joana Barra   +15 more
core   +1 more source

L-Alanine Prototrophic Suppressors Emerge from L-Alanine Auxotroph through Stress-Induced Mutagenesis in Escherichia coli

, 2021
In Escherichia coli, L-alanine is synthesized by three isozymes: YfbQ, YfdZ, and AvtA. When an E. coli L-alanine auxotrophic isogenic mutant lacking the three isozymes was grown on L-alanine-deficient minimal agar medium, L-alanine prototrophic mutants ...
Tasuke Ando, Tomonori Nochi, Harutaka Mishima, Toshitaka Kumagai, Hirokazu Watanabe, Kei Uchigasaki, So Shimoda, Hiroshi Yoneyama, Shota Seki   +8 more
core   +1 more source

Germination of Bacillus cereus spores in response to L-alanine and to inosine: the roles of gerL and gerQ operons [PDF]

, 2002
Bacillus cereus 569 (ATCC 10876) endospores germinate in response to inosine or L-alanine, the most rapid germination response being elicited by a combination of these germinants.
Clements, M.O., Barlass, P.J., Houston, C.W., Moir, A.   +3 more
core  

Effect of l-alanine infusion on 31P nuclear magnetic resonance spectra of normal human liver: towards biochemical pathology in vivo

, 1992
1. 31P n.m.r. spectroscopy in vivo was used to study the effect of l-alanine infusion on the concentrations of gluconeogenic intermediates in normal human liver.
Sargentoni, J., Urenjak, J., Menon, D.K., Dagnelie, P.C., Cox, I.J., Coutts, G.A., Bell, J.D., Iles, R.A.   +7 more
core   +1 more source

Zein‐Based Adhesives: Sustainable Extraction and Application in Bioadhesive Technologies

Advanced Engineering Materials, EarlyView.
Zein is extracted from corn gluten meal using a simple and scalable process with high yield (~90%). The resulting protein is applied in bioadhesives modified with Ca2+ and Fe3+ ions, exhibiting substrate‐dependent adhesion. The findings demonstrate competitive bonding performance and highlight the role of ionic interactions in tuning adhesion ...
Paula Bertolino Sanvezzo, Daniela Winsley Valereto Friozi, Vinícius de Oliveira, Marcia Cristina Branciforti   +3 more
wiley   +1 more source

Biomimetic Nanovaccine Integrating Dendritic Cell Exosomes with Tumor Cell Membranes for Sustained Prophylaxis Against Glioblastoma

Advanced Functional Materials, EarlyView.
We have developed DEX/GM, an all‐natural, personalizable hybrid vaccine designed by coating dendritic cell‐derived exosomes (DEX) onto tumor cell membranes (GM) for sustained prophylaxis against glioblastoma (GBM). ABSTRACT Glioblastoma (GBM), one of the most aggressive and lethal brain tumors, remains incurable with a poor clinical prognosis.
Shanshan Li, Dongya Zhang, Shiyu Wang, Changhe Pang, Meng Zheng, Bingyang Shi, Yan Zou   +6 more
wiley   +1 more source