Results 71 to 80 of about 592,791 (266)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Effects of buffering agents on high-intensity exercise performance and capacity [PDF]

, 2012
High-intensity exercise results in hydrogen ion accumulation, which can have a deleterious effect on muscle function, and thus exercise tolerance. Buffering agents are commonly used to enhance exercise performance and capacity. Two such agents, β-alanine
Saunders, B
core  

Anaerobic induction of alanine aminotransferase in barley root tissue [PDF]

, 1989
Alanine aminotransferase, otherwise called glutamate-pyruvate aminotransferase (GPT), activity increases up to fourfold during several days of anaerobic induction in barley (Hordeum vulgare L.) roots, reaching a maximum activity of 13 intemational units ...
Good, A. G., Crosby, W. L.
core   +1 more source

The Role of Hyperemesis Gravidarum in the First-Trimester as a Predictor of Intrahepatic Cholestasis of Pregnancy

Clinical and Experimental Obstetrics & Gynecology
Background: Intrahepatic cholestasis of pregnancy (ICP) and hyperemesis gravidarum (HEG) are pregnancy-specific liver diseases associated with significant fetal and maternal complications.
Ayça Kubat Küçükyurt, Selma Atiye Kolcu   +1 more
doaj   +1 more source

Effect of Numerous Amino Acids During in vitro Fertilization of Ovums and Epididymal Sperm in Iraqi Awassi Sheep

Kufa Journal for Veterinary Medical Sciences, 2023
In present experiment, the effect of three amino acids, methionine, L-arginine, and D-alanine, on the process of producing embryos in the laboratory, was studied.
Bassam Edress Mahmood, Uday Talat Naoman
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Beta-alanine supplementation improves jumping power and affects severe-intensity performance in professional alpine skiers. [PDF]

, 2014
INTRODUCTION Supplementation with beta-alanine may have positive effects on severe-intensity, intermittent, and isometric strength-endurance performance.
Norman, Barbara, Vogt, M, Vogt, Michael, Gross, Micah, Bieri, Kathrin Susan, Norman, B,, Gross, M, Bieri, Kathrin, Hoppeler, Hans, Hoppeler, H, Hoppeler, Hans-Heinrich, Bieri, K   +11 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Local Order in the Unfolded State: Conformational Biases and Nearest Neighbor Interactions

Biomolecules, 2014
The discovery of Intrinsically Disordered Proteins, which contain significant levels of disorder yet perform complex biologically functions, as well as unwanted aggregation, has motivated numerous experimental and theoretical studies aimed at describing ...
Siobhan Toal, Reinhard Schweitzer-Stenner   +1 more
doaj   +1 more source