Results 71 to 80 of about 109,106 (257)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Taurine-EVA copolymer-paraffin rods dosimeters for EPR high-dose radiation dosimetry

Nukleonika, 2014
Taurine/EPR rods (3 × 10 mm) have been prepared by a simple technique in the laboratory where taurine powder was mixed with a molten mixture of paraffin wax and an ethylene vinyl acetate (EVA) copolymer.
Maghraby Ahmed M., Mansour A., Abdel-Fattah A. A.   +2 more
doaj   +1 more source

The effect of amino acid enantiomers on activity of selected enzymes in soil

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2011
This work was aimed to test the effect of selected amino acid enantiomers on activity of casein-protease and acid phosphomonoesterase in soil. Casein-protease was selected due to its key role in nitrogen mineralization and acid phosphomonoesterase due to
Peter Dundek, Ladislav Holík, Valerie Vranová, Klement Rejšek, Pavel Formánek   +4 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Assembly of Acidic Amphiphiles into Inverted Hexagonal Phases Using an l-Alanine-Based Surfactant as a Structure-Directing Agent^†

, 2016
Several taper-shaped, Brønsted acidic amphiphiles containing an amide linkage near the headgroup were synthesized with the goal of generating acidic, inverted hexagonal (HII) lyotropic liquid crystal (LLC) phases that can be stabilized by polymerization.
Wenjing Zhou (181057), Douglas L. Gin (619971), Weiqiang Gu (2694814), Yanjie Xu (2724739), Cory S. Pecinovsky (2465908)   +4 more
core   +1 more source

Conformational Study of Sequential Polypeptides of L-Alanine and D-Alanine [PDF]

Polymer Journal, 1981
Infrared Spectra in the 700—200 cm−1 and in the amide I and II regions were measured for poly(L-Ala-L-Ala-D-Ala), poly(L-Ala-L-Ala-D-Ala-D-Ala), poly(L-Ala-L-Ala-L-Ala-D-Ala), and poly(L-Ala-D-Ala-L-Ala-D-Ala) with different degrees of polymerization. The spectra showed that the films cast from aqueous solutions of poly(L-Ala-L-Ala-D-Ala), poly(L-Ala-L-
Ozaki, Takuo, Oya, Masanao, Itoh, Koichi
openaire   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Beta-alanine supplementation improves jumping power and affects severe-intensity performance in professional alpine skiers. [PDF]

, 2014
INTRODUCTION Supplementation with beta-alanine may have positive effects on severe-intensity, intermittent, and isometric strength-endurance performance.
Norman, Barbara, Vogt, M, Vogt, Michael, Gross, Micah, Bieri, Kathrin Susan, Norman, B,, Gross, M, Bieri, Kathrin, Hoppeler, Hans, Hoppeler, H, Hoppeler, Hans-Heinrich, Bieri, K   +11 more
core   +1 more source

Exogenous d‐β‐hydroxybutyrate lowers blood glucose in part by decreasing the availability of L‐alanine for gluconeogenesis

Endocrinology, Diabetes & Metabolism, 2022
Background Interventions that induce ketosis simultaneously lower blood glucose and the explanation for this phenomenon is unknown. Additionally, the glucose‐lowering effect of acute ketosis is greater in people with type 2 diabetes (T2D).
Adrian Soto‐Mota, Nicholas G. Norwitz, Rhys D. Evans, Kieran Clarke   +3 more
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source