Results 71 to 80 of about 590,361 (310)

Conformational Study of Sequential Polypeptides of L-Alanine and D-Alanine [PDF]

Polymer Journal, 1981
Infrared Spectra in the 700—200 cm−1 and in the amide I and II regions were measured for poly(L-Ala-L-Ala-D-Ala), poly(L-Ala-L-Ala-D-Ala-D-Ala), poly(L-Ala-L-Ala-L-Ala-D-Ala), and poly(L-Ala-D-Ala-L-Ala-D-Ala) with different degrees of polymerization. The spectra showed that the films cast from aqueous solutions of poly(L-Ala-L-Ala-D-Ala), poly(L-Ala-L-
Ozaki, Takuo, Oya, Masanao, Itoh, Koichi
openaire   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Effect of Numerous Amino Acids During in vitro Fertilization of Ovums and Epididymal Sperm in Iraqi Awassi Sheep

Kufa Journal for Veterinary Medical Sciences, 2023
In present experiment, the effect of three amino acids, methionine, L-arginine, and D-alanine, on the process of producing embryos in the laboratory, was studied.
Bassam Edress Mahmood, Uday Talat Naoman
doaj   +1 more source

Assembly of Acidic Amphiphiles into Inverted Hexagonal Phases Using an l-Alanine-Based Surfactant as a Structure-Directing Agent^†

, 2016
Several taper-shaped, Brønsted acidic amphiphiles containing an amide linkage near the headgroup were synthesized with the goal of generating acidic, inverted hexagonal (HII) lyotropic liquid crystal (LLC) phases that can be stabilized by polymerization.
Wenjing Zhou (181057), Douglas L. Gin (619971), Weiqiang Gu (2694814), Yanjie Xu (2724739), Cory S. Pecinovsky (2465908)   +4 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Radiochromic film dosimetry for VHEE and UHDR: protocol adaptation and verification at the CLEAR facility

Frontiers in Physics
Radiochromic films (RCFs) offer effective two-dimensional dosimetry with a simple, low-cost operating principle, making them suitable for very high-energy electron (VHEE) and ultra-high dose rate (UHDR) applications, where dosimetry standards are lacking.
Vilde F. Rieker, Vilde F. Rieker, Joseph J. Bateman, Laurence Wroe, Misael Caloz, Veljko Grilj, Ygor Q. Aguiar, Andreas Schüller, Claude Bailat, Wilfrid Farabolini, Antonio Gilardi, Cameron Robertson, Pierre Korysko, Pierre Korysko, Alexander Malyzhenkov, Steinar Stapnes, Steinar Stapnes, Marie-Catherine Vozenin, Manjit Dosanjh, Manjit Dosanjh, Roberto Corsini   +20 more
doaj   +1 more source

Local Order in the Unfolded State: Conformational Biases and Nearest Neighbor Interactions

Biomolecules, 2014
The discovery of Intrinsically Disordered Proteins, which contain significant levels of disorder yet perform complex biologically functions, as well as unwanted aggregation, has motivated numerous experimental and theoretical studies aimed at describing ...
Siobhan Toal, Reinhard Schweitzer-Stenner   +1 more
doaj   +1 more source

Markerless Mutagenesis inMethanococcus maripaludisDemonstrates Roles for Alanine Dehydrogenase, Alanine Racemase, and Alanine Permease [PDF]

Journal of Bacteriology, 2005
ABSTRACTAmong the archaea,Methanococcus maripaludishas the unusual ability to usel- ord-alanine as a nitrogen source. To understand how this occurs, we tested the roles of three adjacent genes encoding homologs of alanine dehydrogenase, alanine racemase, and alanine permease.
Brian C, Moore, John A, Leigh
openaire   +2 more sources