Results 81 to 90 of about 109,106 (257)

Threonine 348 regulates the subcellular localization of PTEN

FEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

Effects of beta-alanine supplementation and interval training on physiological determinants of severe exercise performance. [PDF]

, 2014
INTRODUCTION We aimed to manipulate physiological determinants of severe exercise performance. We hypothesized that (1) beta-alanine supplementation would increase intramuscular carnosine and buffering capacity and dampen acidosis during severe ...
Bolliger, Christine, Norman, Barbara, Vogt, Michael, Boesch, Chris, Gross, Micah Ambrose Donovan, Bolliger, Christine S, Gustafsson, Thomas, Hoppeler, Hans, Hoppeler, Hans-Heinrich   +8 more
core   +3 more sources

Green CO₂ Capture from Flue Gas Using Potassium Carbonate Solutions Promoted with Amino Acid Salts

Clean Technologies
CO2 emissions from various anthropogenic activities have led to serious global concerns (climate change and global warming), and, therefore, CO2 capture by sustainable methods is a priority research topic.
Ramona Elena Tataru-Farmus, María Harja, Lucia Tonucci, Francesca Coccia, Michele Ciulla, Liliana Lazar, Gabriela Soreanu, Igor Cretescu   +7 more
doaj   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Circulating metabolite signatures mediating the association between minerals in domestic water and incident MASLD: a prospective cohort study

Frontiers in Nutrition
BackgroundEpidemiological evidence on minerals in domestic water and incident metabolic dysfunction-associated steatotic liver disease (MASLD) remains limited, particularly regarding potential mediating roles of circulating metabolites.
Keyang Li, Yincheng Liu, Wenlong Li, Li Qin, Danrui Zhang, Hong Chen, Zhiyu Yin, Hanwen Zhou, Biao Xie, Xiaoni Zhong   +9 more
doaj   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Deep Eutectic Solvent-Mediated FA‑g‑β-Alanine-co-PCL Drug Carrier for Sustainable and Site-Specific Drug Delivery

, 2018
An amphiphilic polymer that consisted of a deep eutectic solvent (DES)-mediated drug carrier was designed, where the DES influenced the formation of folic acid (FA)-tagged g-β-alanine-co-PCL polymer (DES@FA-g-β-alanine-co-PCL); the nature of the carrier ...
Periyakaruppan Pradeepkumar (6014423), Mariappan Rajan (5920097), Naresh Kumar Rajendran (6014426), Murugan A. Munusamy (807158), Mariappan Rajan, Abdullah A. Alarfaj (807157), Periyakaruppan Pradeepkumar, Abdullah A. Alarfaj, Murugan A. Munusamy, Naresh Kumar Rajendran   +9 more
core   +1 more source

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

2D and 3D interaction diagram of D-alanine-D-alanine ligase protein.

, 2021
The structure shows complex with Rhazin.
Ijaz Rasul (11841071), Usman Ali Ashfaq (9386004), Habibullah Nadeem (1980106), Muhammad Zubair (728141), Hira Saleem (11841068), Muhammad Hussnain Siddique (8966621)   +5 more
core   +1 more source

A Novel KCNA1 Variant in a Patient With Tremor and Autism Spectrum Disorder Causes Mixed LOF/GOF Defects of Kv1.1 Channels

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Variants in KCNA1, encoding the Kv1.1 potassium channel, cause neurological disorders including episodic ataxia and developmental and epileptic encephalopathy. We identified a novel KCNA1 variant (A401T) in a 16‐year‐old patient with autism spectrum disorder, borderline intellectual disability, and tremor, without episodic ataxia or epilepsy ...
Juan Darío Ortigoza‐Escobar, Laura Marti‐Sánchez, Loreto Martorell, Giorgia Dinoi, Antonio Vittorio Buono, Annamaria De Luca, Antonella Liantonio, Paola Imbrici   +7 more
wiley   +1 more source