Results 61 to 70 of about 590,361 (310)
Pharmacokinetics of β-alanine using different dosing strategies [PDF]
, 2018 Introduction: The ergogenic response following long-term ingestion of beta-alanine shows a high inter-individual variation. It is hypothesized that this variation is partially caused by a variable pharmacokinetic response induced by inferior dosing ...
Jan Stautemas +8 more
core +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Clinical and Experimental Obstetrics & GynecologyBackground: Intrahepatic cholestasis of pregnancy (ICP) and hyperemesis gravidarum (HEG) are pregnancy-specific liver diseases associated with significant fetal and maternal complications.
Ayça Kubat Küçükyurt +1 more
doaj +1 more source
Alanine Enhances Aminoglycosides-Induced ROS Production as Revealed by Proteomic Analysis
Frontiers in Microbiology, 2018 Metabolite-enabled killing of antibiotic-resistant pathogens by antibiotics is an attractive strategy to manage antibiotic resistance. Our previous study demonstrated that alanine or/and glucose increased the killing efficacy of kanamycin on antibiotic ...
Jin-zhou Ye +9 more
doaj +1 more source
Graphical representation of predicted dose value distribution for D-alanine-D-alanine ligase.
, 2021 In this graph, x-axis represents distribution of dose value and y-axis represents fraction of compounds.
Ijaz Rasul (11841071) +5 more
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Crystallization and preliminary X-ray analysis of a D-alanyl-D-alanine ligase (EcDdlB) from Escherichia coli [PDF]
, 2010 A recombinant form of Escherichia coli DdlB (EcDdlB) has been prepared and cocrystallized with ADP and D-alanyl-D-alanine to represent the ternary complex of EcDdlB.
David I. Roper +7 more
core +1 more source
Biodegradable polysarcosine with inserted alanine residues: Synthesis and enzymolysis
, 2021 Polysarcosine (PSar), a water-soluble polypeptoid, is gifted with biodegradability via random ring-opening copolymerization of sarcosine- and alanine-N-thiocarboxyanhydrides catalyzed by acetic acid in controlled manners.
Jun, Ling, Peng, Zhou
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Selected amino acids uptake by microorganisms in soil of differently managed mountain meadows
Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2011 This work was aimed at determination of the effect of 13 years abandonment of previously long-term mown mountain meadows on uptake of L-glutamic acid (14CO2H[14CH2]2[NH2]14CO2H) and L-alanine (14CH314CH[NH2]14CO2H) by microbial community of Ap horizon (3–
Valerie Vranová +4 more
doaj +1 more source