Results 61 to 70 of about 109,106 (257)

A single assay for simultaneously testing effectors of alanine racemase and/or D-alanine : D-alanine ligase.

The Journal of Antibiotics, 1987
The biosynthesis from L-alanine of D-alanyl-D-alanine, required for the peptidoglycan layer of the cell wall of many bacterial species, is catalyzed by two enzymes in series, alanine racemase and D-alanine: D-alanine ligase. A simple in vitro method, called the combined assay, for simultaneously testing for effectors of either or both enzymes in a ...
P P, Vicario, B G, Green, H M, Katzen
openaire   +3 more sources

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Surface Chirality in Rotational Magnetoelectrodeposition of Copper Films

Magnetochemistry, 2019
Chiral surface formation was investigated in rotational magnetoelectrodeposition (RMED) of copper films, where an electrochemical cell was rotated in magnetic fields.
Iwao Mogi, Ryoichi Morimoto, Ryoichi Aogaki, Kohki Takahashi   +3 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Effects of buffering agents on high-intensity exercise performance and capacity [PDF]

, 2012
High-intensity exercise results in hydrogen ion accumulation, which can have a deleterious effect on muscle function, and thus exercise tolerance. Buffering agents are commonly used to enhance exercise performance and capacity. Two such agents, β-alanine
Saunders, B
core  

How Hydrophobic Is Alanine? [PDF]

Journal of Biological Chemistry, 2003
By a number of measures, alanine is poised at the threshold between those amino acids that promote the membrane integration of transmembrane alpha-helices and those that do not. We have measured the preference of alanine to partition into the lipid-water interface region over the central acyl chain region of the endoplasmic reticulum (ER) membrane both
IngMarie, Nilsson, Arthur E, Johnson, Gunnar, von Heijne   +2 more
openaire   +2 more sources

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Does beta-alanine supplementation enhance adaptations to resistance training? A randomized, placebo-controlled, double-blind study

, 2022
The aim of the present study was to assess the effects of beta-alanine supplementation on muscle strength and thickness. Nineteen resistance-trained men (age: 27.3±5.5 years; height: 178±10 cm; body mass: 83.4±9.7 kg; training experience: 5.9±3.9 years)
Julio Benvenutti Bueno de Camargo, Paulo Marchetti, Felipe Brigatto, Moises Germano, Marcelo Aoki, Charles Lopes, Tiago Braz, Rafael Zaroni, Darlan Souza, Reury Bacurau   +9 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Histopathological and Enzymatic Changes in Liver of Mice Treated with Tricyclazole

Medical Laboratory Journal, 2017
Background and objectives: Tricyclazole (TCZ) is a member of triazole fungicides, which might cause damage in living systems. This study was carried out to examine effects of TCZ on liver tissues and level of liver enzymes.
Esmail Fattahi
doaj