Results 41 to 50 of about 109,106 (257)

Glutamate Dehydrogenase Is Important for Ammonia Fixation and Amino Acid Homeostasis in Brain During Hyperammonemia

Frontiers in Neuroscience, 2021
Impaired liver function may lead to hyperammonemia and risk for hepatic encephalopathy. In brain, detoxification of ammonia is mediated mainly by glutamine synthetase (GS) in astrocytes.
Caroline M. Voss, Lene Arildsen, Jakob D. Nissen, Helle S. Waagepetersen, Arne Schousboe, Pierre Maechler, Peter Ott, Hendrik Vilstrup, Anne B. Walls   +8 more
doaj   +1 more source

Catabolism of germinant amino acids is required to prevent premature spore germination in Bacillus subtilis

mBio
Spores of Bacillus subtilis germinate in response to specific germinant molecules that are recognized by receptors in the spore envelope. Germinants signal to the dormant spore that the environment can support vegetative growth, so many germinants, such ...
Iqra R. Kasu, Octavio Reyes-Matte, Alejandro Bonive-Boscan, Alan I. Derman, Javier Lopez-Garrido   +4 more
doaj   +1 more source

Infrared Free Electron Laser or Polarized Ultraviolet Photolysis of Hierarchical and Chiral Components of Interleukin-6, AlanylAlanine and Alanine

Trends in Peptide and Protein Sciences, 2021
Interleukin-6 (IL-6) could be decomposed by irradiation of IR-FEL (Infrared free electron laser). Using circularly polarized and other UV light and IR-FEL light, photolysis of hierarchical components of cast films of IL-6, namely deuterated aqueous ...
Nanami Fujisawa, Yuika Onami, Takayasu Kawasaki, Tomoyuki Haraguchi, Takashiro Akitsu, Koichi Tsukiyama   +5 more
doaj   +1 more source

The Amino Acids Glutamic Acid and Alanine in Feed Increase the Alanine Content in Gonads of the Sea Urchin Mesocentrotus nudus

Frontiers in Marine Science, 2020
Taste is an important trait of sea urchin quality. Highly contained alanine in gonads of the sea urchin Mesocentrotus nudus results in desirable taste.
Satomi Takagi, Yuko Murata, Tomohiko Koshiishi, Yukio Agatsuma   +3 more
doaj   +1 more source

High Protein Diets Improve Liver Fat and Insulin Sensitivity by Prandial but Not Fasting Glucagon Secretion in Type 2 Diabetes

Frontiers in Nutrition, 2022
Glucagon (GCGN) plays a key role in glucose and amino acid (AA) metabolism by increasing hepatic glucose output. AA strongly stimulate GCGN secretion which regulates hepatic AA degradation by ureagenesis.
Jiudan Zhang, Olga Pivovarova-Ramich, Olga Pivovarova-Ramich, Olga Pivovarova-Ramich, Stefan Kabisch, Stefan Kabisch, Stefan Kabisch, Mariya Markova, Mariya Markova, Silke Hornemann, Silke Hornemann, Stephanie Sucher, Sascha Rohn, Sascha Rohn, Jürgen Machann, Jürgen Machann, Jürgen Machann, Andreas F. H. Pfeiffer, Andreas F. H. Pfeiffer   +18 more
doaj   +1 more source

Effects of alanine aminotransferase inhibition on the intermediary metabolism in Sparus aurata through dietary amino-oxyacetate supplementation [PDF]

, 2011
In liver, through the reaction catalysed by alanine aminotransferase (ALT), alanine becomes an effective precursor for gluconeogenesis. In the present study amino-oxyacetate (AOA) was used to evaluate its effect on liver ALT activity of the carnivorous ...
Felipe Fernández, Viegas, Iván, Fernández González, Felipe Javier, Caballero Solares, Albert, Isidoro Metón, John G. Jones, Isabel V. Baanante, Barra, Joana, Vázquez Baanante, Ma. Isabel, Ivan Viegas, Albert Caballero, Jones, John G., Juan D. González, González, Juan D., Metón Teijeiro, Isidoro, Joana Barra   +15 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Phage display-derived inhibitor of the essential cell wall biosynthesis enzyme MurF [PDF]

, 2008
Background To develop antibacterial agents having novel modes of action against bacterial cell wall biosynthesis, we targeted the essential MurF enzyme of the antibiotic resistant pathogen Pseudomonas aeruginosa.
Sanschagrin, François, Tom Clarke, Catherine Paradis-Bleau, Blewett, Ann, Roger C Levesque, Clark, Tom, Paradis-Bleau , Catherine, Ann Blewett, Adrian Lloyd, Levesque, Roger C., Lloyd, Adrian, François Sanschagrin, Timothy DH Bugg, Bugg, Tim   +13 more
core   +1 more source

Electron asymmetries in the photoionization of chiral molecules: possible astrophysical implications

Advances in Physics: X, 2018
Photoelectron circular dichroism (PECD) is an intense orbital-specific chiroptical effect observed as asymmetries in the angular distribution of photoelectrons produced by photoionization of randomly oriented pure enantiomers with circularly polarized ...
Rim Hadidi, Dusan K. Bozanic, Gustavo A. Garcia, Laurent Nahon   +3 more
doaj   +1 more source