Results 51 to 60 of about 592,791 (266)

Effects of alanine aminotransferase inhibition on the intermediary metabolism in Sparus aurata through dietary amino-oxyacetate supplementation [PDF]

, 2011
In liver, through the reaction catalysed by alanine aminotransferase (ALT), alanine becomes an effective precursor for gluconeogenesis. In the present study amino-oxyacetate (AOA) was used to evaluate its effect on liver ALT activity of the carnivorous ...
Felipe Fernández, Viegas, Iván, Fernández González, Felipe Javier, Caballero Solares, Albert, Isidoro Metón, John G. Jones, Isabel V. Baanante, Barra, Joana, Vázquez Baanante, Ma. Isabel, Ivan Viegas, Albert Caballero, Jones, John G., Juan D. González, González, Juan D., Metón Teijeiro, Isidoro, Joana Barra   +15 more
core   +1 more source

L-Alanine Prototrophic Suppressors Emerge from L-Alanine Auxotroph through Stress-Induced Mutagenesis in Escherichia coli [PDF]

, 2021
In Escherichia coli, L-alanine is synthesized by three isozymes: YfbQ, YfdZ, and AvtA. When an E. coli L-alanine auxotrophic isogenic mutant lacking the three isozymes was grown on L-alanine-deficient minimal agar medium, L-alanine prototrophic mutants ...
Tasuke Ando, Tomonori Nochi, Harutaka Mishima, Toshitaka Kumagai, Hirokazu Watanabe, Kei Uchigasaki, So Shimoda, Hiroshi Yoneyama, Shota Seki   +8 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Effect of l-alanine infusion on 31P nuclear magnetic resonance spectra of normal human liver: towards biochemical pathology in vivo [PDF]

, 1992
1. 31P n.m.r. spectroscopy in vivo was used to study the effect of l-alanine infusion on the concentrations of gluconeogenic intermediates in normal human liver.
Sargentoni, J., Urenjak, J., Menon, D.K., Dagnelie, P.C., Cox, I.J., Coutts, G.A., Bell, J.D., Iles, R.A.   +7 more
core   +1 more source

Genetically Predicted Circulating Concentrations of Alanine and Alanine Aminotransferase Were Associated with Prostate Cancer Risk

Clinical Epidemiology, 2022
Shaoxue Yang1 *, Jie Song2 *, Hong Yang,2 Wei Liu,2 Yuqing Jiang,2 Xiaohui Sun,2 Ding Ye,2 Songxiao Xu,1 Yingying Mao2 1The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine ...
Yang S, Song J, Yang H, Liu W, Jiang Y, Sun X, Ye D, Xu S, Mao Y   +8 more
doaj  

Metabolic Profile and Performance Responses of Ranunculus asiaticus L. Hybrids as Affected by Light Quality of Photoperiodic Lighting

Frontiers in Plant Science, 2020
Ranunculus asiaticus is a quantitative long day plant grown for cut flowers and flowering potted plants production. We evaluated the influence of light spectrum of three light sources for end-of-day photoperiodic treatments, with different phytochrome ...
Petronia Carillo, Emilia Dell’Aversana, Giuseppe Carlo Modarelli, Giovanna Marta Fusco, Stefania De Pascale, Roberta Paradiso   +5 more
doaj   +1 more source

Genome-wide association analysis of sucrose and alanine contents in edamame beans

Frontiers in Plant Science, 2023
The sucrose and Alanine (Ala) content in edamame beans significantly impacts the sweetness flavor of edamame-derived products as an important attribute to consumers’ acceptance.
Zhibo Wang, Dajun Yu, Gota Morota, Kshitiz Dhakal, William Singer, Nilanka Lord, Haibo Huang, Pengyin Chen, Leandro Mozzoni, Song Li, Bo Zhang   +10 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

The effects of 5 days β-alanine supplementation on the velocity and the percentage o2max at the lactate threshold [PDF]

, 2010
Purpose: To assess the effect of 5 days β-alanine supplementation on the velocity and the percentage of O2max ¬¬ (%O2max) at the lactate threshold (Tlac) during treadmill running.
Johnson, Matthew
core  

Pharmacokinetics of β-alanine using different dosing strategies [PDF]

, 2018
Introduction: The ergogenic response following long-term ingestion of beta-alanine shows a high inter-individual variation. It is hypothesized that this variation is partially caused by a variable pharmacokinetic response induced by inferior dosing ...
Jan Stautemas, Derave, Wim, Stautemas, Jan, Filip B. D. Lefevere, Wim Derave, Everaert, Inge, Inge Everaert, Lefevere, Filip BD, Lefevere, Filip   +8 more
core   +1 more source