Results 161 to 170 of about 590,361 (310)

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

Alanine [PDF]

, 2020
openaire   +1 more source

Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation

Advanced Science, EarlyView.
VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang, Qihao Li, Kun Ye, Kezhi Liu, Mi Zhou, Minyu Chen, Lican Liao, Kangbo Huang, Zhu Wang, Qiong Deng, Jieyan Wang, Meiyu Jin, Xu Chen, Hui Liang, Jiaxing Zhang, Junhang Luo   +15 more
wiley   +1 more source

Effects of β-alanine supplementation on kickboxing-specific anaerobic performance, neuromuscular power, and strength endurance: A randomized, double-blind, placebo-controlled trial. [PDF]

PLoS One
Küçük FH, Gençoğlu C, Ateş O, Da Silva Duarte JDR, Belošević D, Çabuk S, İnaç MR, Ulupınar S, Özbay S.   +8 more
europepmc   +1 more source

Effects of β-Alanine Supplementation on Subjects Performing High-Intensity Functional Training

Background: β-alanine, a non-essential amino acid found in the diet and produced through nucleotide catabolism, is significant for muscle performance due to its role in carnosine synthesis.
Juan Pablo Hervás-Pérez, Cimadevilla-Fernández-Pola, Eduardo, Eduardo Cimadevilla-Fernández-Pola, Hernández-Lougedo, Juan, Guodemar-Pérez, Jesús, Maté Muñoz, José Luis, Maria Aránzazu Sánchez-Calabuig, Martínez-Roldán, Cristina, Pablo García-Fernández, Juan Hernández-Lougedo, Jose Luis Maté-Muñoz, Sánchez-Calabuig, Maria Aránzazu, García Fernández, Pablo, Cristina Martínez-Roldán, Hervás-Pérez, Juan Pablo, Jesús Guodemar-Pérez   +15 more
core   +1 more source

Quantitative Mass Spectrometry‐Based Biodistribution of Monoclonal Antibodies: An Alternative to Radio‐Biodistribution

Advanced Science, EarlyView.
Monoclonal antibodies are powerful anticancer therapeutics targeting tumor‐associated antigens. Mass spectrometry enables precise and accurate quantification of mAbs in tumor plasma and healthy organs. Unlike ligand binding assay and radioactivity, mass spectrometry does not suffer from matrix effects and labelling artefacts while facilitating method ...
Domenico Ravazza, Sheila Dakhel Plaza, Samuele Cazzamalli, Andrea Ciamarone, Andrea Galbiati, Riccardo Stucchi, Frederik Peissert, Emanuele Puca, Dario Neri, Ettore Gilardoni   +9 more
wiley   +1 more source

Correction: Alanine-scanning mutagenesis library of MreB reveals distinct roles for regulating cell shape and viability. [PDF]

PLoS Genet
Maharjan S, Sloan R, Lusk J, Bevienguevarr R, Surber J, Morgenstein RM.   +5 more
europepmc   +1 more source

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source

Poolside Activity Measurement of Cobalt Target

Journal of Isotopes
To obtain cobalt target activity data after a cycle of irradiation in a pressurized water reactor, the cobalt target dose distribution was measured underwater using alanine dosimeters.
YIN Zhenguo1, LIAN Qi2, ZHANG Ping1, XU Bei2, WANG Mingming2, FENG Wuzhou1, YAN Tianyu1
doaj  

Beta-Alanine and Aquagenic Pruritus: Proposed Neuroimmune Mechanism. [PDF]

JMIR Dermatol
Piserchio N, Baratta B, Brooks B, Muse B, Ball K.   +4 more
europepmc   +1 more source