Results 91 to 100 of about 469,247 (341)

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Blood alanine aminotransferase levels >1,000 IU/l - causes and outcomes.

Clinical medicine (London), 2015
Standard medical education dictates that the vast majority of cases of an alanine aminotransferase (ALT) level >1,000 IU/l will be due to acute ischaemia, acute drug-induced liver injury (DILI) (usually paracetamol) or acute viral hepatitis.
Z. Galvin, A. Mcdonough, J. Ryan, S. Stewart   +3 more
semanticscholar   +1 more source

The AUTACE That Degrades KRAS and Engages CD8+ T Cells for the Treatment of KRAS/TP53 Co‐Mutant Tumors

Advanced Science, EarlyView.
AUTACE is a bifunctional nanoplatform that integrates tumor targeting, immune engagement, and on‐demand KRAS degradation. It targets KRAS/TP53 co‐mutant tumors via TP53‐specific TCRs, elicits antitumor CD8+ T‐cell responses through surface anti‐CD3 antibodies, and uses low‐intensity focused ultrasound (LIFU) to trigger controlled release of the KRAS ...
Luo Li, Bolin Li, Yanan Hao, Bo Pang, Pan Li, Chunli Li, Yu Tang   +6 more
wiley   +1 more source

Effects of Ashwagandha (Withania somnifera) Root Extract On Some Serum Liver Marker Enzymes (AST, ALT) In Gentamicin Intoxicated Rats

Journal of Bangladesh Society of Physiologists, 2012
Background: Liver is an essential metabolic organ. It can be damaged due to prolonged use and higher doses of drugs, exposure to some chemicals, toxins, or infectious agents.
Nayma Sultana, Sadia Choudhury Shimmi, M Tanveer Hossain Parash, Jesmine Akhtar   +3 more
doaj  

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

The ratio of aspartate aminotransferase to alanine aminotransferase (AST/ALT): the correlation of value with underlying severity of alcoholic liver disease.

Kathmandu University Medical Journal, 2015
BACKGROUND Alcoholic liver disease is one of the most frequently diagnosed liver problems in the hospitalized patients in most tertiary care hospitals all over the world .The diagnosis of alcoholic liver disease is most of the time clinical.
R. Gurung, B. Purbe, P. Gyawali, P. Risal   +3 more
semanticscholar   +1 more source

Liver functions and medication adherence in tuberculosis patients after 6 months of antituberculosis treatment in Indonesia

Journal of International Medical Research
Objective The objective of this study was to assess liver functions in tuberculosis patients after 6 months of treatment and determine the difference in the level of liver enzymes based on medication adherence and patient characteristics. Methods We used
Dyah Aryani Perwitasari, Triantoro Safaria, Didik Setiawan, Haafizah Dania, Salma Auliya Fatimah, Imaniar Noor Faridah   +5 more
doaj   +1 more source

Taper-in-Taper Fiber Structure-based LSPR Sensor for Alanine Aminotransferase Detection

Optics Express, 2021
Zhi Wang, R. Singh, C. Marques, R. Jha, Bingyuan Zhang, Santosh Kumar   +5 more
semanticscholar   +1 more source

Alanine Aminotransferase-Old Biomarker and New Concept: A Review

International Journal of Medical Sciences, 2014
Measurement of serum alanine aminotransferase (ALT) is a common, readily available, and inexpensive laboratory assay in clinical practice. ALT activity is not only measured to detect liver disease, but also to monitor overall health.
Zhengtao Liu, S. Que, Jing Xu, T. Peng
semanticscholar   +1 more source

Decreased alanine aminotransferase activity in serum of man during γacetylenic-GABA treatment

, 1980
Decreasing concentrations of alanine aminotransferase were observed in nine patients receiving γacetylenic-GABA, an inhibitor of GABA aminotransferase. In vitro studies showed that preincubation at 37°C of serum with γacetylenic-GABA and with urine from ...
Hørder, Mogens, Olsen, Ruth
core   +1 more source