Results 101 to 110 of about 469,247 (341)

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

EFEK LIKOPEN TERHADAP TIKUS PUTIH GALUR SD (Sprague Dawley) YANG DIINDUKSI PARASETAMOL DENGAN MELIHAT AKTIVITAS SGPT DALAM DARAH

Pharmaciana, 2011
Liver is one of the most important organ for drug metabolism in the body. The damage to the liver can be marked by increased activity of the enzyme alanine aminotransferase (ALT) in the blood.
Risha Maysara, Sapto Yuliani
doaj   +1 more source

Alkaline Phosphatase (ALP), Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) Activities in Selected Tissues of Rats Fed on Processed Atlantic Horse Mackerel (Trachurus trachurus)

, 2015
Trachurus trachurus (locally called kote) is a table fish that has become increasingly important in the Nigerian diet because of its low price. Therefore, this study investigated the effects of processed kote on the activities of alkaline phosphatase ...
O. Adeyemi, O. Osilesi, O. Adebawo, F. Onajobi, S. Oyedemi, A. Afolayan   +5 more
semanticscholar   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Relationship between macronutrients and energy intake and liver serum transaminase levels in elderly athletes and non-athletes: findings from the Neyshabur longitudinal study on aging

BMC Geriatrics
Background Assessing liver health and its determinants in the elderly is crucial. Lifestyle factors, including nutrition and exercise, may influence liver function.
Hossein Taghizadeh Bilondi, Seyyed Mostafa Arabi, Fatemeh Mohammadzadeh, Seyed Reza Mirhafez, Alireza Ostadrahimi   +4 more
doaj   +1 more source

Serum alanine aminotransferase (ALT) and the different biochemical phenotypes of DILI.

, 2022
Serum alanine aminotransferase (ALT) and the different biochemical phenotypes of DILI.
Raza Akbar (13569758), Aisha Al Boinin (13569752), Lina Mohammad Naseralallah (11014412), Fatima Al Hattab (13569755), Mohammed I. Danjuma (13569767), Waseem Umer (13569761), Layla Abdul Jabbar (13569764), Nejat Mohamed Geryo (13569749), Bodoor Abdallah Aboujabal (13569746)   +8 more
core   +1 more source

FGL2‐HDAC11 Drives Immunothrombosis via NETs‐Mediated Endothelial Capillarization in MASLD Fibrosis

Advanced Science, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is frequently accompanied by hepatic fibrosis and systemic cardiovascular complications; however, the mechanistic interplay between coagulation abnormalities and disease progression remains poorly defined.
Xitang Li, Junjian Hu, Suping Hai, Peng Hu, Wenhui Wu, Qiang Gao, Binghui Yu, Feiyang Xu, Xizhe Zheng, Qianting Guan, Huiling Xiang, Dong Xi, Weiming Yan, Peng Wang, Bin‐hao Zhang, Qin Ning, Xiaojing Wang   +16 more
wiley   +1 more source

Correlation between plasma betatrophin concentration and alanine aminotransferase level.

, 2015
Betatrophin level positively correlates with alanine aminotransferase level in all subjects (r = 0.195, P = 0.016).
Kairui Jin (780764), Peihong Chen (780765), Xuemei Yu (780768), Hua Jin (320594), Cheng Hu (44938), Lili Yang (116313), Ting Gao (255221), Xinmiao Xie (780766), Meili Yang (780767)   +8 more
core   +1 more source

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

Alanine Aminotransferase Elevation in Obese Infants and Children: A Marker of Early Onset Non Alcoholic Fatty Liver Disease

Hepatitis Monthly, 2014
Background: Elevated aminotransferases serve as surrogate markers of non-alcoholic fatty liver disease, a feature commonly associated with the metabolic syndrome.
G. Engelmann, G. Hoffmann, J. Grulich-Henn, U. Teufel   +3 more
semanticscholar   +1 more source