Results 111 to 120 of about 469,247 (341)

A Higher Alanine Aminotransferase Level Correlates with Earlier Hepatitis B E Antigen Seroconversion in Lamivudine-Treated Chronic Hepatitis B Patients

, 2009
BACKGROUND/AIMS: A pretherapy serum alanine aminotransferase (ALT) level above five times the upper limit of normal (ULN ) is known to predict hepatitis B e antigen (HBeAg) seroconversion during lamivudine therapy for chronic hepatitis B patients ...
曾岱宗;劉俊人;王嘉齊;陳培哲;賴明陽;高嘉宏;陳定信, TSENG, TAI-CHUNG;LIU, CHUN-JEN;WANG, CHIA-CHI;CHEN, PEI-JER;LAI, MING-YANG;KAO, JIA-HORNG;CHEN, DING-SHINN;KAO, JIA- HORNG   +1 more
core  

Sensitivity and specificity of alanine aminotransferase, stratified by gender.

, 2012
ALT, alanine aminotransferase; HBV, hepatitis B virus; NAFLD, nonalcoholic fatty liver disease; CI, confidence interval; ULN, upper limit of normal.
Wen-Yue Liu (138454), Ke-Qing Shi (138450), Yong-Ping Chen (138457), Ming-Hua Zheng (138448), Xian-Feng Lin (138455), Ling-Fei Li (138456), Yu-Chen Fan (138452)   +6 more
core   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

Hepatoma‐Derived Growth Factor Coordinates STAT3 Pathway and Exosome‐Mediated Intrahepatic Crosstalk to Control Hepatic Steatosis and MASLD

Advanced Science, EarlyView.
Hepatic HDGF as a key mediator in coordinating hepatic steatosis and intrahepatic crosstalk in MASLD. Activation of HDGF facilitates its interaction with both STAT3 and S6K1, driving the S6K1‐dependent STAT3 phosphorylation and subsequently enhancing hepatic lipogenesis.
Jian Wen, Dong Ding, Zengpeng Zheng, Xufeng Chen, Wenjing Li, Jiaxin Shen, Zhiwei Huang, Peng Tan, Junjie Bai, Xia Fang, Baofang Xing, Puyuan Hu, Linghao Xu, Haokai Yu, Yixi Wang, Zongzhe Jiang, Yang Long, Tiejun Zhou, Mingxin Ye, Yu Jiang, Aoyuan Cui, Hong Li, Qiurong Ding, Yong Xu, Yu Li, Weitong Su, Feng Shen, Chenlin Gao, Wenguang Fu   +28 more
wiley   +1 more source

Evaluation of the impact of an acute single paracetamol overdose on renal functions and serum electrolytes [PDF]

Minia Journal of Medical Research
Background: Paracetamol overdose is a common cause of drug-induced acute liver injury worldwide. The easy availability of the drug makes it a common method of suicide especially among young adults.
Aya Roshdi, Osama Hassan, Mohamed Ahmed, Asmaa Abd-EL Azeem   +3 more
doaj   +1 more source

Vitamin E and changes in serum alanine aminotransferase levels in patients with non-alcoholic steatohepatitis

Alimentary Pharmacology and Therapeutics, 2013
Non‐alcoholic steatohepatitis (NASH) is a common cause of serum alanine aminotransferase (ALT) elevations and chronic liver disease, but it is unclear how well ALT elevations reflect the liver injury.
J. Hoofnagle, M. Natta, D. Kleiner, J. Clark, K. Kowdley, R. Loomba, B. Neuschwander‐Tetri, A. Sanyal, J. Tonascia   +8 more
semanticscholar   +1 more source

Optimized Ex Vivo Human Liver Slice Culture Maintains Extended Viability and Function for Hepatotoxicity Testing

Advanced Science, EarlyView.
An optimized ex vivo human liver slice culture system preserves tissue architecture, hepatocyte function, and immune‐stromal complexity for at least five days. By refining slice thickness, oxygenation, air‐liquid interface, and extracellular matrix support, the platform enables human‐relevant hepatotoxicity testing and mechanistic studies, offering a ...
Huiche Feng, Cinzia Esposito, Andrej Benjak, Matthias S. Matter, Miriam Cieri, Camilla De Carlo, Philipp Sedlaczek, Fabian Haak, Mattia Marinucci, Gabriel Fridolin Hess, Otto Kollmar, Mairene Coto‐Llerena, Luca Di Tommaso, Visar Vela, Lukas Bubendorf, Luigi M. Terracciano, Charlotte K. Y. Ng, Salvatore Piscuoglio   +17 more
wiley   +1 more source

Histologic Abnormalities in Children with Nonalcoholic Fatty Liver Disease and Normal or Mildly Elevated Alanine Aminotransferase Levels

Jornal de Pediatria, 2013
Objectives To investigate the histological spectrum of nonalcoholic fatty liver disease (NAFLD) in children with normal, mildly elevated (26–50 U/L boys, 23–44 U/L girls), or elevated (> 50 boys, > 44 girls) serum alanine aminotransferase (ALT) levels ...
J. Molleston, J. Schwimmer, Katherine P. Yates, K. Murray, O. Cummings, J. Lavine, E. Brunt, A. Scheimann, A. Unalp-arida   +8 more
semanticscholar   +1 more source

Predictive Effect of Serial Serum Alanine Aminotransferase Levels on Spontaneous HBeAg Seroconversion in Chronic Genotype B and C HBV-Infected Children

, 2014
Objective: The present study aimed to investigate the association between serial serum alanine aminotransferase (ALT) and spontaneous hepatitis B e antigen (HBeAg) seroconversion age in chronic hepatitis B virus (HBV)-infected children.
Wu, Jia-Feng;Su, Yu-Ru;Chen, Chen-Hsin;Chen, Huey-Ling;Ni, Yen-Hsuan;Hsu, Hong-Yuan;Wang, Jane-Ling;Chang, Mei-Hwei, 倪衍玄 ;張美惠 ;許宏遠 ;吳嘉峰 ;陳慧玲   +1 more
core  

Bioorthogonal Fluorogenic Reporters for Noninvasive Imaging and Urinalysis of Immunotherapeutic Response in Renal Cell Carcinoma

Advanced Science, EarlyView.
This study reported renal‐clearable bio‐orthogonal near‐infrared fluorogenic probes (BGRs) that specifically imaging and urinalysis of granzyme B for dynamic evaluation of RCC immunotherapy. BGRs not only differentiate immunotherapeutic responses in orthotopic RCC mice, but also enable sensitive optical urinalysis of granzyme B in clinical specimens ...
Xingyue Yang, Baoshuai Liang, Liangmin Fu, Weiliang Deng, Yuyan Jiang, Weiping Xu, Jinwei Chen, Ya Zhou, Ke Wu, Jiaguo Huang   +9 more
wiley   +1 more source