Results 141 to 150 of about 469,247 (341)

A Microgel Platform Enables Site‐Specific Intestinal Delivery of Lactoferrin, Improving its Bioavailability for Targeted Alleviating Liver Injury and Colitis

Advanced Science, EarlyView.
This work first time reports an eco‐friendly desert plant food‐based polysaccharide ASKP microgels which have intestinal site‐specific release properties which can achieve small‐intestine or colon targeting capability via different cross‐linking chemistry.
Huiling Yan, Yixuan Li, Shanan Chen, Pengcheng Du, Kaiwen Wu, Hui Zhang, Kasper Hettinga, Lina Zhang, Gergely Toldi, Fazheng Ren, Yuan Li   +10 more
wiley   +1 more source

Influence of Eclipta alba on serum alanine aminotransferase and aspartate aminotransferase activity in rabbits

, 2018
Background: Paracetamol is a recognized antipyretic, analgesic drug which produces hepatic necrosis in high doses. Eclipta alba elaborates a vast array of biologically active compounds that are chemically diverse and structurally complex.Methods ...
Kale, B. P., Rauf, Mujawar Jahir, B. P. Kale, Mujawar Jahir Rauf   +3 more
core   +1 more source

Effects of GS-0976 on plasma alanine aminotransferase and aspartate aminotransferase levels.

, 2020
(A) Plasma alanine aminotransferase levels. (B) Plasma aspartate aminotransferase levels. Plasma was obtained before and after the 8-week treatment. The hollow column shows values pre-treatment and the shaded column shows values post-treatment for the ...
Kazunobu Aoyama (1786444), Derek M. Erion (568011), Xiaolun Wang (2252662), Tadahiro Nambu (835562), Hitomi Ogino (2084590), Sayuri Nakamura (513377), Mayumi Nishida (1880404), Mitsuharu Matsumoto (181952), Hiroaki Yashiro (2231686), Manami Kaneko (3590468)   +9 more
core   +1 more source

Ciclopirox Olamine Inhibits the NLRP3 Inflammasome to Alleviate Inflammatory Diseases

Advanced Science, EarlyView.
There is no drug targeting the NLRP3 inflammasome that has been approved for use in clinical settings. Ciclopirox olamine (CPX), an antifungal agent approved by the US Food and Drug Administration (FDA), is identified as a specific and potent NLRP3 inflammasome inhibitor. CPX targets the NACHT domain of NLRP3 at Y381 to impair NLRP3 oligomerization and
Xinyu Xia, Hui You, Ke Zhang, Hui Jiang, Hongping Liu, Lianghua Liu, Aijie Zhang, You Zhou   +7 more
wiley   +1 more source

Association of liver enzyme abnormalities and tobacco exposure with unexplained recurrent spontaneous abortion risk: A case–control study

Journal of International Medical Research
Objective Unexplained recurrent spontaneous abortion is a multifactorial condition with an unclear etiology. This study aimed to investigate the relationship between liver function biomarkers and unexplained recurrent spontaneous abortion and explore ...
Xiaolei Xue, Congcong Fang, Hanjing Zhou, Huan Zhou, Wei Li, Di Lei   +5 more
doaj   +1 more source

Supramolecular Assembly of Stepped‐Persistent ROS Nanogenerator for Sustained Tumor Immunotherapy

Advanced Science, EarlyView.
ROS catalytic systems often fail to achieve both effective tumor elimination and persistent immune activation due to their monotonous ROS production profiles. A stepped‐persistent ROS nanogenerator was developed by supramolecularly assembling multiple ROS generation modules within a nanofiber structure to simultaneously extend ROS generation duration ...
Zhenqiang Wang, Ming Qin, Wenjing Lai, Shiwen Chen, Fengling Wang, Dandan Xie, Maohua Chen, Changpeng Hu, Kui Wang, Rong Zhang, Guobing Li   +10 more
wiley   +1 more source

Relationship of hepatic steatosis and alanine aminotransferase with coronary calcification. [Letter]

, 2011
Relationship of hepatic steatosis and alanine aminotransferase with coronary ...
Giovanni Targher, TARGHER, Giovanni
core   +1 more source

Multi‐Axis Stretchable Zippers for Personalized Wound Healing

Advanced Science, EarlyView.
Multi‐axis stretchable zippers can adapt to complex wound morphologies and enable personalized wound treatment through programmable contraction. This morphological matching strategy helps accelerate wound closure, improve blood perfusion, promote epithelial regeneration, and enhance collagen remodeling, pioneering new directions for personalized and ...
Siyuan Cai, Guang Yao, Zijian Chen, Shiqi Zhou, Peisi Li, Liheng Lin, Huake Yang, Ziyi Zhou, Linbo Jin, Xingyi Gan, Chenzheng Zhou, Zhen Cai, Taisong Pan, Min Gao, Dongli Fan, Yuan Lin, Yiming Zhang   +16 more
wiley   +1 more source

Senescent Cell Derived Artificial Vesicle‐Based Senolytic Sonovaccine Platform with Augmented Lymph Node Delivery and Antigen Cross‐Presentation Efficacy

Advanced Science, EarlyView.
A senolytic sonovaccine platform (SenoVac) is developed, in which senescent cell‐derived vesicles serve as broad senescent cell antigen reservior. The “2‐step” click chemistry strategy for effective lymph node delivery, and ultrasound‐triggered endosomal escape to boost cross‐presentation, ensures efficient senescent cell clearance and disease ...
Liang Zhang, Yubo Lai, Jia Wang, Lingling Liu, Jieyuan An, Mi Qu, Yuan Liang, Bijun Tan, Guodong Yang, Xuekang Yang, Lijun Yuan   +10 more
wiley   +1 more source

Alanine aminotransferase [PDF]

Hepatology, 2009
openaire   +1 more source