Alanine Represses γ-Aminobutyric Acid Utilization and Induces Alanine Transaminase Required for Mitochondrial Function in Saccharomyces cerevisiae [PDF]
Frontiers in Microbiology, 2021 The γ-aminobutyric acid (GABA) shunt constitutes a conserved metabolic route generating nicotinamide adenine dinucleotide phosphate (NADPH) and regulating stress response in most organisms.
Dariel Márquez +5 more
doaj +3 more sources
Prognostic Value of Aspartate Transaminase/Alanine Transaminase Ratio in Patients With Hepatitis B Virus-Related Hepatocellular Carcinoma Undergoing Hepatectomy [PDF]
Frontiers in Oncology, 2022 BackgroundAspartate transaminase/alanine transaminase (De Ritis) ratio is a good predictor of liver function damage, but its prognostic value in patients with hepatocellular carcinoma (HCC) undergoing hepatectomy remains unclear.
Qiuyan Mo +13 more
doaj +3 more sources
Prognostic Role of Pretreatment De Ritis Ratio (Aspartate Transaminase/Alanine Transaminase Ratio) in Urological Cancers: A Systematic Review and Meta-Analysis [PDF]
Frontiers in Oncology, 2020 Background: To examine the potential prognostic significance of pretreatment De Ritis ratio (aspartate transaminase/alanine transaminase ratio) in urological cancers, including upper tract urothelial cancer (UTUC), renal cell carcinoma (RCC), prostate ...
Shiqiang Su +4 more
doaj +3 more sources
Silencing alanine transaminase 2 in diabetic liver attenuates hyperglycemia by reducing gluconeogenesis from amino acids. [PDF]
Cell Rep, 2022 Hepatic gluconeogenesis from amino acids contributes significantly to diabetic hyperglycemia, but the molecular mechanisms involved are incompletely understood.
Martino MR +16 more
europepmc +3 more sources
Antiviral Therapy Favors a Lower Risk of Liver Cirrhosis in HBeAg-negative Chronic Hepatitis B with Normal Alanine Transaminase and HBV DNA Positivity. [PDF]
J Clin Transl Hepatol, 2023 Background and Aims Direct evidence on the outcomes of hepatitis B e antigen (HBeAg)-negative chronic hepatitis B (CHB) patients with normal alanine transaminase after long-term antiviral treatment is lacking.
Zhou J +5 more
europepmc +2 more sources
Characterization of T cell immunity in chronic hepatitis B virus-infected mothers with postpartum alanine transaminase flare. [PDF]
BMC Infect Dis, 2021 Background Postpartum alanine transaminase (ALT) flares occur frequently in chronic hepatitis B virus (HBV)-infected mothers with antepartum antiviral therapy (AVT).
Huang M +6 more
europepmc +2 more sources
The association of aspartate transaminase-to-alanine transaminase ratio and metabolic syndrome among HIV patients in Sidama Region, South Ethiopia [PDF]
SAGE Open Medicine, 2023 Objective: Studies on the association of the aspartate transaminase-to-alanine transaminase ratio with the metabolic syndrome and its components among HIV patients were scarce.
Wondwossen Abera +2 more
doaj +2 more sources
The Effect of Elevated Alanine Transaminase on Non-invasive Prenatal Screening Failures [PDF]
Frontiers in Medicine, 2022 ObjectiveTo determine the effects of alanine transaminase (ALT) levels on the screening failure rates or “no calls” due to low fetal fraction (FF) to obtain a result in non-invasive prenatal screening (NIPS).MethodsNIPS by sequencing and liver enzyme ...
Ping Chen +11 more
doaj +2 more sources
Prognostic value of aspartate transaminase to alanine transaminase (De Ritis) ratio in solid tumors: a pooled analysis of 9,400 patients. [PDF]
Onco Targets Ther, 2019 Background Numerous studies have reported the association between pretreatment serum aspartate transaminase to alanine transaminase (AST/ALT) ratio and prognosis in multiple cancers.
Wu J +5 more
europepmc +2 more sources
UC Davis - Alanine transaminase v1 [PDF]
protocols.io, 2019 Summary: Alanine transaminase (ALT) also known as alanine aminotransferase or (sGPT) is a metabolic enzyme expressed primarily in the liver. Elevation of ALT levels is an indication of liver damage and has been associated with liver injury. ALT levels are monitored routinely in patients with liver diseases.
Peter Havel
openaire +2 more sources